Richard H Fitzpatrick

US Patent:

6419914, Jul 16, 2002

Filed:

Jun 11, 2001

Appl. No.:

09/878843

Inventors:

Caroline Isabelle Bacon Kurtz - Sudbury MA
Richard Fitzpatrick - Marblehead MA

Assignee:

GelTex Pharmaceuticals, Inc. - Waltham MA

International Classification:

A61K 3174

US Classification:

424 7808, 424 7801, 424 7818, 424 7831

Abstract:

The present invention relates to a method of inhibiting a toxin in an animal, such as a human, by administering to the animal a therapeutically effective amount of a polymer having a plurality of pendant acid functional groups which are directly attached to the polymer backbone or attached to the polymer backbone by a spacer group. The spacer group can have a length in the range from 0 to about 20 atoms. The toxin is, typically, an exotoxin secreted by a pathogenic microorganism, such as a bacterium.

US Patent:

6565895, May 20, 2003

Filed:

Jun 8, 2001

Appl. No.:

09/877723

Inventors:

Philip J. Goddard - West Newton MA
Jeffrey D. Klinger - Sudbury MA
Pradeep K. Dhal - Westford MA
Richard J. Fitzpatrick - Marblehead MA
Thomas X. Neenan - Cambridge MA

Assignee:

GelTex Pharmaceuticals, Inc. - Waltham MA

International Classification:

A61K 3324

US Classification:

424653, 424 49, 424 53, 514184, 514503, 514557, 514574, 514901, 514902, 514925, 514928

Abstract:

The invention relates to the unexpected discovery that bismuth-containing compounds are effective in the treatment of oral mucositis in a mammal. Thus, the invention relates, in one aspect to a method of treating oral mucositis comprising administering an effective amount of a pharmaceutically acceptable bismuth-containing compound, such as a bismuth salt or bismuth complex. In a preferred embodiment, the bismuth compound is an organic or inorganic salt such as, bismuth subsalicylate, bismuth subgallate, bismuth aluminate, bismuth citrate, bismuth subcitrate, bismuth carbonate, bismuth subcarbonate, tripotassium dicitrato bismuthate, bismuth nitrate, bismuth subnitrate, bismuth tartrate and mixtures thereof, preferably, bismuth subsalicylate and bismuth subgallate.

US Patent:

6517826, Feb 11, 2003

Filed:

Nov 28, 2000

Appl. No.:

09/723596

Inventors:

Caroline Isabelle Bacon Kurtz - Sudbury MA
Richard Fitzpatrick - Marblehead MA

Assignee:

GelTex Pharmaceuticals, Inc. - Waltham MA

International Classification:

A61K 3174

US Classification:

424 7808, 424 781, 424 7818, 424 7817, 4241671

Abstract:

The present invention relates to a method of inhibiting a toxin in an animal, such as a human, by administering to the animal a therapeutically effective amount of a polymer having a plurality of pendant acid functional groups which are directly attached to the polymer backbone or attached to the polymer backbone by a spacer group. The spacer group can have a length in the range from 0 to about 20 atoms. The toxin is, typically, an exotoxin secreted by a pathogenic microorganism, such as a bacterium.

US Patent:

6517827, Feb 11, 2003

Filed:

Jul 9, 2001

Appl. No.:

09/901206

Inventors:

Caroline Isabelle Bacon Kurtz - Sudbury MA
Richard Fitzpatrick - Marblehead MA

Assignee:

GelTex Pharmaceuticals, Inc. - Waltham MA

International Classification:

A61K 3174

US Classification:

424 7808, 424 7801, 424 7818, 424 7831, 424 781, 4241671

Abstract:

The present invention relates to a method of inhibiting a toxin in an animal, such as a human, by administering to the animal a therapeutically effective amount of a polymer having a plurality of pendant acid functional groups which are directly attached to the polymer backbone or attached to the polymer backbone by a spacer group. The spacer group can have a length in the range from 0 to about 20 atoms. The toxin is, typically, an exotoxin secreted by a pathogenic microorganism, such as a bacterium.

US Patent:

6692732, Feb 17, 2004

Filed:

Dec 19, 2002

Appl. No.:

10/324623

Inventors:

Richard Fitzpatrick - Marblehead MA
Chad Cori Huval - Somerville MA
Caroline Isabelle Bacon Kurtz - Sudbury MA
Thomas X. Neenan - Cambridge MA

Assignee:

Genzyme Corporation - Cambridge MA

International Classification:

A61K 3174

US Classification:

424 7808, 424 781, 424 7812, 424 7813, 424 7814, 424 7831, 424 7833

Abstract:

A method for treating pathogenic toxins in a mammal, such as a human, comprising treating the mammal with a therapeutically effective amount of a polymer comprising a cationic group attached to the polymer backbone. The polymer can be a homopolymer or a copolymer. In one embodiment, the polymer is a copolymer comprising a monomer having a pendant ammonium group and a hydrophobic monomer.

US Patent:

6730295, May 4, 2004

Filed:

May 1, 2001

Appl. No.:

09/847053

Inventors:

Richard J. Fitzpatrick - Marblehead MA

Assignee:

Genzyme Corporation - Waltham MA

International Classification:

A61K 3174

US Classification:

424 7828, 424 7808, 424 7817, 424 7827

Abstract:

The present invention relates to the discovery that certain anionic polymers have useful antibacterial activity.

US Patent:

6890523, May 10, 2005

Filed:

Nov 14, 2002

Appl. No.:

10/295019

Inventors:

Caroline Isabelle Bacon Kurtz - Sudbury MA, US
Richard Fitzpatrick - Marblehead MA, US

Assignee:

Genzyme Corporation - Cambridge MA

International Classification:

A61K031/74

US Classification:

424 7808, 424 7801, 424 7818, 424 7831

Abstract:

The present invention relates to a method of inhibiting a toxin in an animal, such as a human, by administering to the animal a therapeutically effective amount of a polymer having a plurality of pendant acid functional groups which are directly attached to the polymer backbone or attached to the polymer backbone by a spacer group. The spacer group can have a length in the range from 0 to about 20 atoms. The toxin is, typically, an exotoxin secreted by a pathogenic microorganism, such as a bacterium.

US Patent:

6955806, Oct 18, 2005

Filed:

Jan 17, 2002

Appl. No.:

10/051765

Inventors:

Richard J. Fitzpatrick - Marblehead MA, US
Keith K. Shackett - Athol MA, US
Jeffrey D. Klinger - Sudbury MA, US

Assignee:

Genzyme Corporation - Cambridge MA

International Classification:

A61K031/785
A61K031/74
A61F013/00
C08G073/06

US Classification:

424 7836, 424 781, 424402, 424 7012, 424422, 528423

Abstract:

Disclosed are ionene polymers having antimicrobial activity. “Ionene polymers” as used in this invention are cationic polymers in which a substantial proportion of the atoms providing the positive charge are quaternized nitrogens located in the main polymeric chain or backbone of the polymer rather than in pendant groups. Also disclosed are antimicrobial compositions comprising ionene polymers and methods for treating microbial infections in mammals comprising the step of administering to a mammal, a therapeutically effective amount of at least one antimicrobial composition of the invention. Also disclosed are antimicrobial compositions comprising at least one ionene polymer and methods for preventing, inhibiting or eliminating the growth, dissemination, and/or the accumulation of microorganisms on a susceptible surface (including, but not limited to, the formation of biofilms on a susceptible surface) comprising the step of contacting such surface with a composition of the invention.