Richard L Goodwin

US Patent:

7338517, Mar 4, 2008

Filed:

Jun 4, 2004

Appl. No.:

10/861664

Inventors:

Michael J. Yost - Lexington SC, US
C. Michael Gore - West Columbia SC, US
Louis Terracio - New York NY, US
Richard L. Goodwin - Columbia SC, US
Edie C. Goldsmith - Lexington SC, US

Assignee:

University of South Carolina - Columbia SC

International Classification:

A61F 2/06
A61F 2/00

US Classification:

623 11, 424423

Abstract:

A tubular tissue scaffold is described which comprises a tube having a wall, wherein the wall includes biopolymer fibrils that are aligned in a helical pattern around the longitudinal axis of the tube where the pitch of the helical pattern changes with the radial position in the tube wall. The scaffold is capable of directing the morphological pattern of attached and growing cells to form a helical pattern around the tube walls. Additionally, an apparatus for producing such a tubular tissue scaffold is disclosed, the apparatus comprising a biopolymer gel dispersion feed pump that is operably connected to a tube-forming device having an exit port, where the tube-forming device is capable of producing a tube from the gel dispersion while providing an angular shear force across the wall of the tube, and a liquid bath located to receive the tubular tissue scaffold from the tube-forming device. A method for producing the tubular tissue scaffolds is also disclosed. Also, artificial tissue comprising living cells attached to a tubular tissue scaffold as described herein is disclosed.

US Patent:

7727441, Jun 1, 2010

Filed:

Feb 25, 2008

Appl. No.:

12/072167

Inventors:

Michael J. Yost - Lexington SC, US
C. Michael Gore - West Columbia SC, US
Louis Terracio - New York NY, US
Richard L. Goodwin - Columbia SC, US
Edie C. Goldsmith - Lexington SC, US

International Classification:

B29C 47/40
B29C 47/20

US Classification:

2642091, 264178, 264473

Abstract:

A tubular tissue scaffold is described which comprises a tube having a wall, wherein the wall includes biopolymer fibrils that are aligned in a helical pattern around the longitudinal axis of the tube where the pitch of the helical pattern changes with the radial position in the tube wall. The scaffold is capable of directing the morphological pattern of attached and growing cells to form a helical pattern around the tube walls. Additionally, an apparatus for producing such a tubular tissue scaffold is disclosed, the apparatus comprising a biopolymer gel dispersion feed pump that is operably connected to a tube-forming device having an exit port, where the tube-forming device is capable of producing a tube from the gel dispersion while providing an angular shear force across the wall of the tube, and a liquid bath located to receive the tubular tissue scaffold from the tube-forming device. A method for producing the tubular tissue scaffolds is also disclosed. Also, artificial tissue comprising living cells attached to a tubular tissue scaffold as described herein is disclosed.

US Patent:

7878786, Feb 1, 2011

Filed:

Feb 25, 2008

Appl. No.:

12/072150

Inventors:

Michael J. Yost - Lexington SC, US
C. Michael Gore - West Columbia SC, US
Louis Terracio - New York NY, US
Richard L. Goodwin - Columbia SC, US
Edie C. Goldsmith - Lexington SC, US

Assignee:

University of South Carolina - Columbia SC

International Classification:

B29C 47/24

US Classification:

425 71, 425 721, 425 73, 425381, 425461

Abstract:

An apparatus for producing a tubular tissue scaffold having aligned biopolymer fibrils including a biopolymer gel dispersion feed pump that is operably connected to a tube-forming device having an exit port, where the tube-forming device is capable of producing a tube from the gel dispersion while providing an angular shear force across the wall of the tube, and a liquid bath located to receive the tubular tissue scaffold from the tube-forming device.

US Patent:

20080147199, Jun 19, 2008

Filed:

Feb 25, 2008

Appl. No.:

12/072232

Inventors:

Michael J. Yost - Lexington SC, US
C. Michael Gore - West Columbia SC, US
Louis Terracio - New York NY, US
Richard L. Goodwin - Columbia SC, US
Edie C. Goldsmith - Lexington SC, US

Assignee:

University of South Carolina - Columbia SC

International Classification:

A61F 2/02
C12Q 1/02
C12N 5/02

US Classification:

623 2372, 435 29, 435395

Abstract:

A tubular tissue scaffold is described which comprises a tube having a wall, wherein the wall includes biopolymer fibrils that are aligned in a helical pattern around the longitudinal axis of the tube where the pitch of the helical pattern changes with the radial position in the tube wall. The scaffold is capable of directing the morphological pattern of attached and growing cells to form a helical pattern around the tube walls. Additionally, an apparatus for producing such a tubular tissue scaffold is disclosed, the apparatus comprising a biopolymer gel dispersion feed pump that is operably connected to a tube-forming device having an exit port, where the tube-forming device is capable of producing a tube from the gel dispersion while providing an angular shear force across the wall of the tube, and a liquid bath located to receive the tubular tissue scaffold from the tube-forming device. A method for producing the tubular tissue scaffolds is also disclosed. Also, artificial tissue comprising living cells attached to a tubular tissue scaffold as described herein is disclosed. Methods for using the artificial tissue are also disclosed.

US Patent:

20230107315, Apr 6, 2023

Filed:

Oct 5, 2022

Appl. No.:

17/960462

Inventors:

- Colombia SC, US
MIHYUN L. WAUGH - CAYCE SC, US
NICHOLAS D. BOLTIN - COLUMBIA SC, US
LAUREN WOLF - CAMBRIDGE MA, US
RONNIE HORNER - OMAHA NE, US
MATTHEW HERMES - SIMPSONVILLE SC, US
THOMAS WHEELER - GREENVILLE SC, US
RICHARD GOODWIN - GREENVILLE SC, US
RICHARD MICHAEL GOWER - COLUMBIA SC, US

International Classification:

G16H 50/30
G16B 5/00
G16B 40/20

Abstract:

In general, the present disclosure is directed to systems and methods of evaluating a subject's risk of one or more complications associated with pelvic organ prolapse surgery. The method comprising: obtaining, by a computing system comprising one or more computing devices, sample data associated with the subject; inputting, by the computing system, the sample data into a machine-learned immune response model; receiving, by the computing system as an output of the machine-learned immune response model, one or more predictions of post-surgical complications of mesh exposure through the vaginal wall associated with the subject; and performing a pelvic organ prolapse repair surgery on the subject, wherein the surgery is performed based at least in part on the one or more predictions of post-surgical complications by the machine-learned immune response model associated with a likelihood of success.