Richard H Gregg

US Patent:

6492365, Dec 10, 2002

Filed:

Jun 7, 1995

Appl. No.:

08/486929

Inventors:

Daru Young Sharp - Perrineville NJ
Richard E. Gregg - Pennington NJ

Assignee:

Bristol-Myers Squibb Company - New York NY

International Classification:

C07D26106

US Classification:

514247, 514277

Abstract:

Nucleic acid sequences, particularly DNA sequences, coding for all or part of the high molecular weight subunit of microsomal triglyceride transfer protein, expression vectors containing the DNA sequences, host cells containing the expression vectors, and methods utilizing these materials. The invention also concerns polypeptide molecules comprising all or part of the high molecular weight subunit of microsomal triglyceride transfer protein, and methods for producing these polypeptide molecules. The invention additionally concerns novel methods for preventing, stabilizing or causing regression of atherosclerosis and therapeutic agents having such activity. The invention concerns further novel methods for lowering serum liquid levels and therapeutic agents having such activity.

US Patent:

8233971, Jul 31, 2012

Filed:

Aug 4, 2008

Appl. No.:

12/672298

Inventors:

Sophia Zhou - Caramillo CA, US
Shankar Reddy - Windham NH, US
Richard E. Gregg - Westford MA, US
James Lindauer - San Francisco CA, US
Eric Helfenbein - Sunnyvale CA, US

Assignee:

Koninklijke Philips Electronics N.V. - Eindhoven

International Classification:

A61B 5/04

US Classification:

600509

Abstract:

A diagnostic ECG system analyzes lead traces for evidence of ST elevation in the lead signals. The pattern of ST elevation in leads having predetermined vantage points to the electrical activity of the heart and, in some instances, the presence of ST depression in certain other leads, identifies a specific coronary artery or branch as the culprit coronary artery for an acute ischemic event. The identity of the culprit coronary artery or branch is presented to the interventional cardiologist so that the correct coronary artery is accessed and the obstruction cleared. The technique can be used with standard 12-lead ECG systems as well as with ECG systems using fewer or more leads.

US Patent:

8560058, Oct 15, 2013

Filed:

Jan 9, 2009

Appl. No.:

12/811841

Inventors:

Saeed Babaeizadeh - Brookline MA, US
Richard E. Gregg - Westford MA, US
Eric Helfenbein - Sunnyvale CA, US
Sophia Huai Zhou - Camarillo CA, US

Assignee:

Koninklijke Philips N.V. - Eindhoven

International Classification:

A61B 5/0402

US Classification:

600518

Abstract:

An atrial fibrillation (AF) monitor extracts two P wave features and an R-R interval feature from a sequence of ECG waveforms. The features are used by a classifier to classify a heart rhythm as AF or non-AF. The AF classification results may be further processed to reduce false alarm reporting. The AF classification results are used by an AF burden calculator to report AF burden in real time.

US Patent:

20030166590, Sep 4, 2003

Filed:

Aug 21, 2001

Appl. No.:

09/933593

Inventors:

John Wetterau - Langhorne PA, US
Daru Sharp - Perrineville NJ, US
Richard Gregg - Pennington NJ, US
Scott Biller - Ewing NJ, US
John Dickson - Mount Holly NJ, US
R. Lawrence - Yardley PA, US
John Lawson - Wallingford CT, US
Henry Holava - Meriden CT, US
Richard Partyka - Neshanic NJ, US

International Classification:

A61K048/00
C07H021/04

US Classification:

514/044000, 536/023200

Abstract:

Nucleic acid sequences, particularly DNA sequences, coding for all or part of the high molecular weight subunit of microsomal triglyceride transfer protein, expression vectors containing the DNA sequences, host cells containing the expression vectors, and methods utilizing these materials. The invention also concerns polypeptide molecules comprising all or part of the high molecular weight subunit of microsomal triglyceride transfer protein, and methods for producing these polypeptide molecules. The invention additionally concerns novel methods for preventing, stabilizing or causing regression of atherosclerosis and therapeutic agents having such activity. The invention concerns further novel methods for lowering serum liquid levels and therapeutic agents having such activity.

US Patent:

20100234749, Sep 16, 2010

Filed:

Oct 20, 2008

Appl. No.:

12/738419

Inventors:

Richard Gregg - Westford MA, US
Sophia Zhou - Camarillo CA, US

Assignee:

KONINKLIJKE PHILIPS ELECTRONICS N.V. - Eindhoven

International Classification:

A61B 5/0402

US Classification:

600509

Abstract:

A system and method for receiving a request for a test to be performed on a patient, retrieving information about the patient, receiving further information about the test after the test is performed and comparing the information to the further information. In addition, a system having an input device for receiving a request for a test to be performed on a patient and a management system configured to retrieve information corresponding to the patient, combine the received request and the retrieved information into a modified request, and forward the modified request to a device performing the test.

US Patent:

20130060156, Mar 7, 2013

Filed:

Apr 25, 2011

Appl. No.:

13/643114

Inventors:

Richard E. Gregg - Westford MA, US
Sophia Huai Zhou - Briarcliff Manor NY, US

Assignee:

KONINKLIJKE PHILIPS ELECTRONICS N.V. - EINDHOVEN

International Classification:

A61B 5/044

US Classification:

600523

Abstract:

The segments of an anatomically corresponding bull's eye graph familiar to echocardiologists is annotated by coloring those segments for which ECG data indicates the presence of myocardial infarction injury. In an illustrated example, segments are colored with a second color when the ECG data corresponding to those segments are indicated as being the site of a coronary occlusion. The segments of the bull's eye graph may be colored in a third color with the results of a diagnostic imaging exam, such as by coloring segments exhibiting wall motion abnormalities with a third color.

US Patent:

20130237870, Sep 12, 2013

Filed:

Nov 28, 2011

Appl. No.:

13/883842

Inventors:

Richard Gregg - Westford MA, US
Sophia Huai Zhou - Briarcliff Manor NY, US
Cheng-Hao Chien - Thousand Oaks CA, US

Assignee:

KONINKLIJKE PHILIPS ELECTRONICS N.V. - EINDHOVEN

International Classification:

A61B 5/02
A61B 5/04
A61B 5/0468

US Classification:

600509

Abstract:

A diagnostic ECG system analyzes lead traces for evidence of ST elevation in the lead signals. The pattern of ST elevation in leads having predetermined vantage points to the electrical activity of the heart and, in some instances, the presence of ST depression in certain other leads, identifies a specific coronary artery or branch as the culprit coronary artery for an acute ischemic event. ECG measurements which are associated with the identity of specific arterial occlusion locations are calculated and used to form a classifier of the probability of occlusion at different locations. The location identified as having the highest probability is indicated to a user as the most likely occlusion location.

US Patent:

60666536, May 23, 2000

Filed:

Jan 10, 1998

Appl. No.:

9/005437

Inventors:

Richard E. Gregg - Pennington NJ
John R. Wetterau - Langhorne PA

Assignee:

Bristol-Myers Squibb Co. - Princeton NJ

International Classification:

A61K 31445
A61K 3121

US Classification:

514325

Abstract:

A method is provided for inhibiting or treating diseases associated with acid lipase deficiency by administering to a patient an MTP inhibitor, alone or optionally, in combination with another cholesterol lowering drug, such as pravastatin.