Richard D Gregg

US Patent:

6492365, Dec 10, 2002

Filed:

Jun 7, 1995

Appl. No.:

08/486929

Inventors:

Daru Young Sharp - Perrineville NJ
Richard E. Gregg - Pennington NJ

Assignee:

Bristol-Myers Squibb Company - New York NY

International Classification:

C07D26106

US Classification:

514247, 514277

Abstract:

Nucleic acid sequences, particularly DNA sequences, coding for all or part of the high molecular weight subunit of microsomal triglyceride transfer protein, expression vectors containing the DNA sequences, host cells containing the expression vectors, and methods utilizing these materials. The invention also concerns polypeptide molecules comprising all or part of the high molecular weight subunit of microsomal triglyceride transfer protein, and methods for producing these polypeptide molecules. The invention additionally concerns novel methods for preventing, stabilizing or causing regression of atherosclerosis and therapeutic agents having such activity. The invention concerns further novel methods for lowering serum liquid levels and therapeutic agents having such activity.

US Patent:

20030166590, Sep 4, 2003

Filed:

Aug 21, 2001

Appl. No.:

09/933593

Inventors:

John Wetterau - Langhorne PA, US
Daru Sharp - Perrineville NJ, US
Richard Gregg - Pennington NJ, US
Scott Biller - Ewing NJ, US
John Dickson - Mount Holly NJ, US
R. Lawrence - Yardley PA, US
John Lawson - Wallingford CT, US
Henry Holava - Meriden CT, US
Richard Partyka - Neshanic NJ, US

International Classification:

A61K048/00
C07H021/04

US Classification:

514/044000, 536/023200

Abstract:

Nucleic acid sequences, particularly DNA sequences, coding for all or part of the high molecular weight subunit of microsomal triglyceride transfer protein, expression vectors containing the DNA sequences, host cells containing the expression vectors, and methods utilizing these materials. The invention also concerns polypeptide molecules comprising all or part of the high molecular weight subunit of microsomal triglyceride transfer protein, and methods for producing these polypeptide molecules. The invention additionally concerns novel methods for preventing, stabilizing or causing regression of atherosclerosis and therapeutic agents having such activity. The invention concerns further novel methods for lowering serum liquid levels and therapeutic agents having such activity.

US Patent:

60666536, May 23, 2000

Filed:

Jan 10, 1998

Appl. No.:

9/005437

Inventors:

Richard E. Gregg - Pennington NJ
John R. Wetterau - Langhorne PA

Assignee:

Bristol-Myers Squibb Co. - Princeton NJ

International Classification:

A61K 31445
A61K 3121

US Classification:

514325

Abstract:

A method is provided for inhibiting or treating diseases associated with acid lipase deficiency by administering to a patient an MTP inhibitor, alone or optionally, in combination with another cholesterol lowering drug, such as pravastatin.

US Patent:

57891974, Aug 4, 1998

Filed:

Jun 7, 1995

Appl. No.:

8/486924

Inventors:

John R. Wetterau - Langhorne PA
Daru Young Sharp - Perrineville NJ
Richard E. Gregg - Pennington NJ

Assignee:

E. R. Squibb & Sons, Inc. - Princeton NJ

International Classification:

C12P 2102
C07K 1400
C12Q 100
C12Q 125

US Classification:

435 691

Abstract:

Nucleic acid sequences, particularly DNA sequences, coding for all or part of the high molecular weight subunit of microsomal triglyceride transfer protein, expression vectors containing the DNA sequences, host cells containing the expression vectors, and methods utilizing these materials. The invention also concerns polypeptide molecules comprising all or part of the high molecular weight subunit of microsomal triglyceride transfer protein, and methods for producing these polypeptide molecules. The invention additionally concerns novel methods for preventing, stabilizing or causing regression of atherosclerosis and therapeutic agents having such activity. The invention concerns further novel methods for lowering serum liquid levels and therapeutic agents having such activity.

US Patent:

58831096, Mar 16, 1999

Filed:

May 12, 1997

Appl. No.:

8/854311

Inventors:

Richard E. Gregg - Pennington NJ
Hubert G. Pouleur - Lawrenceville NJ
John R. Wetterau - Langhorne PA

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

A61K 31445

US Classification:

514321

Abstract:

A method is provided for lowering serum lipids, cholesterol and/or triglycerides and thereby inhibiting atherosclerosis by administering to a patient an MTP inhibitor, in combination with a cholesterol lowering drug, such as pravastatin.

US Patent:

55958729, Jan 21, 1997

Filed:

Sep 3, 1993

Appl. No.:

8/117362

Inventors:

John R. Wetterau - Langhorne PA
Daru Y. Sharp - Perrineville NJ
Richard E. Gregg - Pennington NJ
Scott A. Biller - Ewing NJ
John K. Dickson - Mount Holly NJ
R. Michael Lawrence - Yardley PA
John E. Lawson - Wallingford CT
Henry M. Holava - Meriden CT
Richard A. Partyka - Neshanic NJ

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

C12Q 170
C07H 2102
C12N 1579
C12N 510

US Classification:

435 6

Abstract:

Nucleic acid sequences, particularly DNA sequences, coding for all or part of the high molecular weight subunit of microsomal triglyceride transfer protein, expression vectors containing the DNA sequences, host cells containing the expression vectors, and methods utilizing these materials. The invention also concerns polypeptide molecules comprising all or part of the high molecular weight subunit of microsomal triglyceride transfer protein, and methods for producing these polypeptide molecules. The invention additionally concerns novel methods for preventing, stabilizing or causing regression of atherosclerosis and therapeutic agents having such activity. The invention concerns further novel methods for lowering serum liquid levels and therapeutic agents having such activity.

US Patent:

60573392, May 2, 2000

Filed:

Jan 10, 1998

Appl. No.:

9/005430

Inventors:

Richard E. Gregg - Pennington NJ

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

A61K 31445
A61K 3121

US Classification:

514325

Abstract:

A method is provided for inhibiting onset of or treating phytosterolemia by administering to a patient an MTP inhibitor, alone or optionally, in combination with another cholesterol lowering drug, such as pravastatin.

US Patent:

20180133220, May 17, 2018

Filed:

Jan 12, 2018

Appl. No.:

15/869300

Inventors:

- Parsippany NJ, US
Richard E. Gregg - Pennington NJ, US

International Classification:

A61K 31/506

Abstract:

Provided herein are compounds and pharmaceutically acceptable salts thereof that are useful therapeutics for acute coronary syndrome and related disorders.