Richard J Gregory

US Patent:

20030113823, Jun 19, 2003

Filed:

Oct 9, 2002

Appl. No.:

10/268017

Inventors:

Richard Gregory - Carmel IN, US

International Classification:

G01N033/554
G01N033/569
A61K007/16

US Classification:

435/007320, 424/049000

Abstract:

The invention overcomes the limitations of the prior art by providing rapid assays for predicting the likelihood of caries development in patients. The assays allow implementation of appropriate dental care measures during a patient visit depending on the results of the assay. The assay utilizes the finding that caries-free children and adults have significantly higher levels of naturally occurring protective salivary IgA antibody to than caries-active subjects. The assays are carried out using patient saliva. The speed and ease of use of the assay allows dental practitioners to assess at an early stage the relative risk of future caries formation. With this information, preventive methods may be applied only to those determined to be at risk.

US Patent:

20050207995, Sep 22, 2005

Filed:

Apr 21, 2004

Appl. No.:

10/828837

Inventors:

Richard Gregory - Carmel IN, US
Diana Catt - Mooresville IN, US

International Classification:

A61K007/28

US Classification:

424050000

Abstract:

Described are methods and compositions for promoting oral health in a host that involve the administration of a 65 kDa protein from or a fragment or functional analog thereof, to the oral cavity of the host. The 65 kDa protein exhibits murein hydrolase enzyme activity and in inventive embodiments the enzyme or active fragments can be used to lyse bacteria commonly present in dental plaque or other surfaces of the oral cavity. Methods for controlling dental caries include administering non-immunogenic polypeptides from bacterial adhesions to competitively block bacterial attachment without implicating the immune system of the host. Novel isolated DNA encoding the 65 kDa protein or a fragment thereof, as well as recombinant forms of the protein or fragment, and methods for their production, are also described.

US Patent:

20060127961, Jun 15, 2006

Filed:

Jan 26, 2006

Appl. No.:

11/340051

Inventors:

Richard Gregory - Carmel IN, US

International Classification:

G01N 33/554
C12M 1/34
G01N 33/569

US Classification:

435007320, 435287200

Abstract:

The invention overcomes the limitations of the prior art by providing rapid assays for predicting the likelihood of caries development in patients. The assays allow implementation of appropriate dental care measures during a patient visit depending on the results of the assay. The assay utilizes the finding that caries-free children and adults have significantly higher levels of naturally occurring protective salivary IgA antibody to than caries-active subjects. The assays are carried out using patient saliva. The speed and ease of use of the assay allows dental practitioners to assess at an early stage the relative risk of future caries formation. With this information, preventive methods may be applied only to those determined to be at risk.

US Patent:

20210145827, May 20, 2021

Filed:

Jan 25, 2021

Appl. No.:

17/156671

Inventors:

- Indianapolis IN, US
Jeffrey A. Platt - Indianapolis IN, US
Richard L. Gregory - Carmel IN, US

Assignee:

Indiana University Research and Technology Corporation - Indianapolis IN

International Classification:

A61K 31/496
A61K 31/4164
A61K 9/06
A61K 47/38
A61P 31/02
A61K 47/02

Abstract:

Antibiotic gel formulations for use in dental applications are disclosed. More particularly, the present disclosure is directed to antibiotic gel formulations including low concentrations of antibiotics that are capable of killing root canal pathogens without harming the stem cells inside the root canal. Additionally, the present disclosure is directed to delivery systems and methods for applying the antibiotic gel formulations into a subject's intracanal region.

US Patent:

20180263860, Sep 20, 2018

Filed:

Aug 23, 2016

Appl. No.:

15/756811

Inventors:

- Indianapolis IN, US
Jeffrey A. Platt - Indianapolis IN, US
Richard L. Gregory - Carmel IN, US

International Classification:

A61K 6/00

Abstract:

Antibiotic gel formulations for use in dental applications are disclosed. More particularly, the present disclosure is directed to antibiotic gel formulations including low concentrations of antibiotics that are capable of killing root canal pathogens without harming the stem cells inside the root canal. Additionally, the present disclosure is directed to delivery systems and methods for applying the antibiotic gel formulations into a subject's intracanal region.

US Patent:

20180250292, Sep 6, 2018

Filed:

Aug 23, 2016

Appl. No.:

15/756793

Inventors:

- Indianapolis IN, US
Jeffrey A. Platt - Indianapolis IN, US
Richard L. Gregory - Carmel IN, US

International Classification:

A61K 31/496
A61K 47/38
A61K 47/02
A61K 9/06
A61P 31/02

Abstract:

Antibiotic gel formulations for use in dental applications are disclosed. More particularly, the present disclosure is directed to antibiotic gel formulations including low concentrations of antibiotics that are capable of killing root canal pathogens without harming the stem cells inside the root canal. Additionally, the present disclosure is directed to delivery systems and methods for applying the antibiotic gel formulations into a subject's intracanal region.