Richard D Gregory

US Patent:

6432927, Aug 13, 2002

Filed:

May 26, 2000

Appl. No.:

09/579897

Inventors:

Richard J. Gregory - Westford MA
Karen Vincent - Arlington MA

Assignee:

Genzyme Corporation - Cambridge MA

International Classification:

A61K 3170

US Classification:

514 44, 4353201, 435325, 435 914, 435455, 536 234, 536 241, 424 932

Abstract:

The present invention provides recombinant nucleic acid molecules encoding a chimeric transactivator protein including a DNA binding domain of a DNA binding protein and a protein domain capable of transcriptional activation. The present invention also provides recombinant viral and non-viral vectors that are able to infect and/or transfect and sustain expression of a biologically active chimeric transactivator proteins in mammalian cells. Also provided are host cell lines and non-human transgenic animals capable of expressing biologically active chimeric transactivator proteins. In another aspect, compositions and methods for treating or preventing ischemic damage associated with hypoxia-related disorders are provided.

US Patent:

7053062, May 30, 2006

Filed:

Jul 3, 2002

Appl. No.:

10/190394

Inventors:

Richard J. Gregory - Westford MA, US
Karen Vincent - Arlington MA, US

Assignee:

Genzyme Corporation - Cambridge MA

International Classification:

A61K 31/70
C12N 15/00
C12N 15/63
C07H 21/04

US Classification:

514 44, 4353201, 435455, 536 234

Abstract:

The present invention provides recombinant nucleic acid molecules encoding a chimeric transactivator protein including a DNA binding domain of a DNA binding protein and a protein domain capable of transcriptional activation. The present invention also provides recombinant viral and non-viral vectors that are able to infect and/or transfect and sustain expression of a biologically active chimeric transactivator proteins in mammalian cells. Also provided are host cell lines and non-human transgenic animals capable of expressing biologically active chimeric transactivator proteins. In another aspect, compositions and methods for treating or preventing ischemic damage associated with hypoxia-related disorders are provided.

US Patent:

7118911, Oct 10, 2006

Filed:

Jul 2, 1993

Appl. No.:

08/087132

Inventors:

Richard Gregory - Ayer MA, US
Seng H. Cheng - Boston MA, US
Alan Smith - Wellesley MA, US
Sucharita Paul - Grafton MA, US
Kathleen M. Hehir - Grafton MA, US
John Marshall - Milford MA, US

Assignee:

Genzyme Corporation - Cambridge MA

International Classification:

C12N 15/00
C07H 21/00

US Classification:

4353201, 536 231

Abstract:

Disclosed are full length isolated DNAs encoding cystic fibrosis transmembrane conductance regulator (CFTR) protein and a variety of mutants thereof. Also disclosed are antibodies specific for various CFTR domains and methods for their production. Expression of CFTR from cells transformed with these CFTR genes or cDNAs demonstrate surprising CFTR intracellular distributions and results thereby providing for new diagnostic and therapeutic procedures.

US Patent:

7318919, Jan 15, 2008

Filed:

Jun 3, 2002

Appl. No.:

10/161539

Inventors:

Richard Gregory - Westford MA, US
Donna Armentano - Belmont MA, US
Larry A. Couture - Louisville CO, US
Alan E. Smith - Dover MA, US

Assignee:

Genzyme Corporation - Cambridge MA

International Classification:

A61K 48/00
C12N 15/861

US Classification:

424 932, 4353201, 435455, 435456

Abstract:

Gene Therapy vectors, which are especially useful for cystic fibrosis, and methods for using the vectors are disclosed.

US Patent:

8283331, Oct 9, 2012

Filed:

Oct 8, 2008

Appl. No.:

12/682149

Inventors:

Richard I Gregory - Brookline MA, US
George Q Daley - Weston MA, US
Srinivas R Viswanathan - Brookline MA, US

Assignee:

Children's Medical Center Corporation - Boston MA

International Classification:

C12N 15/11

US Classification:

514 44A

Abstract:

The present invention relates generally to methods to regulate microRNA (miRNA) biogenesis, in particular the regulation of the processing of pri-miRNA to mature miRNA by Lin-28 and/or variants such as Lin28B. In particular, the present invention relates to methods and compositions comprising at least one agent which inhibits Lin-28 function or activity and/or expression to increase the processing of pri-mRNA to mature miRNA. More specifically, one aspect of the invention is directed to treating and/or preventing cancer in a subject by administering an agent that inhibits Lin-28 activity or expression to a subject, preferably a human subject.

US Patent:

20020137212, Sep 26, 2002

Filed:

May 18, 2001

Appl. No.:

09/860211

Inventors:

Richard Gregory - Westford MA, US
Ken Wills - San Diego CA, US
Daniel Maneval - Carlsbad CA, US

Assignee:

Canji,Inc. - San Diego CA

International Classification:

C12N015/861
C12N007/01

US Classification:

435/456000, 435/235100, 435/320100

Abstract:

This invention provides a recombinant adenovirus expression vector characterized by the partial or total deletion of the adenoviral protein IX DNA and having a gene encoding a foreign protein or a functional fragment or mutant thereof. Transformed host cells and a method of producing recombinant proteins and gene therapy also are included within the scope of this invention. Thus, for example, the adenoviral vector of this invention can contain a foreign gene for the expression of a protein effective in regulating the cell cycle, such as p53, Rb, or mitosin, or in inducing cell death, such as the conditional suicide gene thymidine kinase. (The latter must be used in conjunction with a thymidine kinase metabolite in order to be effective).

US Patent:

20020164782, Nov 7, 2002

Filed:

May 11, 2000

Appl. No.:

09/568756

Inventors:

Richard Gregory - Westford MA, US
Donna Armentano - Belmont MA, US
Larry Couture - Louisville CO, US
Alan Smith - Dover MA, US

International Classification:

A61K048/00
C12N015/74
C12N005/06

US Classification:

435/320100, 435/325000, 424/093200

Abstract:

Gene Therapy vectors, which are especially useful for cystic fibrosis, and methods for using the vectors are disclosed.

US Patent:

20030141837, Jul 31, 2003

Filed:

Jan 30, 2002

Appl. No.:

10/058325

Inventors:

Stuart Young - Burke VA, US
Richard Gregory - Mount Airy MD, US

International Classification:

G05B011/01

US Classification:

318/560000

Abstract:

Robot and remote controlled devices have been utilized for information gathering purposes. However these robotic vehicles lack efficiency because they are not capable of operating out of doors or where the sensors and apparatus located on the robots are subject to harsh environments. The present invention provides a new and unique manner of overcoming these problems by providing a platform system that is placed upon existing robots without requiring adjustments to these devices. The platform effectuates easy installation of a plurality of sensors and apparatus on its top surface while providing internal housing for its wires and components, thereby providing a water, dirt and dust resistant environment which leads to better equipment function and ease of maintenance and repair.