Richard J Haack

US Patent:

6506876, Jan 14, 2003

Filed:

Oct 11, 1994

Appl. No.:

08/321184

Inventors:

Nizal Samuel Chandrakumar - Vernon Hills IL
Barbara Baosheng Chen - Glenview IL
Michael Clare - Skokie IL
Bipinchandra Nanubhai Desai - Vernon Hills IL
Stevan Wakefield Djuric - Malvern PA
Stephen Hermann Docter - Mt. Prospect IL
Alan Frank Gasiecki - Vernon Hills IL
Richard Arthur Haack - Chicago IL
Julie Marion Miyashiro - Chicago IL
Thomas Dale Penning - Elmhurst IL
Mark Andrew Russell - Gurnee IL
Stella Siu-tzyy Yu - Morton Grove IL

Assignee:

G.D. Searle Co. - Chicago IL

International Classification:

A01N 4340

US Classification:

530330, 514317, 546225

Abstract:

The present invention provides compounds of the formula Ar âQâAr âYâRâZ and pharmaceutically acceptable salts thereof wherein Ar and Ar are optionally substituted aryl moieties, Z is an optionally substituted nitrogen-containing moiety which may be an acyclic, cyclic or bicyclic amine or an optionally substituted monocyclic or bicyclic nitrogen-containing heteroaromatic moiety; Q is a linking group capable of linking two aryl groups; R is an alkylene moiety; Y is a linking moiety capable of linking an aryl group to an alkylene moiety and wherein Z is bonded to R through a nitrogen atom. The compounds and pharmaceutical compositions of the present invention are useful in the treatment of inflammatory diseases which are mediated by LTB production, such as psoriasis, ulcerative colitis, IBD and asthma.

US Patent:

48553247, Aug 8, 1989

Filed:

Feb 18, 1988

Appl. No.:

7/158454

Inventors:

Stevan W. Djuric - Glenview IL
Richard A. Haack - Chicago IL
Stella S. Yu - Morton Grove IL

Assignee:

G. D. Searle & Co. - Chicago IL

International Classification:

C07C 5990
C07C 5948
A61K 31557

US Classification:

514570

Abstract:

This invention relates to a compound of the formula: ##STR1## or a pharmaceutically acceptable salt thereof wherein X is oxygen, sulfur, or --CH. dbd. CH--; wherein Z is OR. sup. 1 or --NR. sup. 4 R. sup. 5 ; wherein R. sup. 1 is hydrogen, lower alkyl, or a pharmaceutically acceptable cation; wherein R. sup. 2 is H, --CH. sub. 3 or --C. sub. 2 H. sub. 5 ; wherein R. sup. 3 is OH, H or. dbd. O; wherein R. sup. 4 and R. sup. 5 may independently be hydrogen, or lower alkyl having 1-6 carbon atoms, or R. sup. 4 and R. sup. 5 may act together with N to form a cyclic amide of the formula: ##STR2## wherein n is an integer from 4-5; and m is an integer from 0-4. More particularly, this invention relates to compounds of the above formula which have utility as LTB. sub. 4 antagonists.

US Patent:

49719971, Nov 20, 1990

Filed:

Aug 7, 1989

Appl. No.:

7/390567

Inventors:

Stevan W. Djuric - Glenview IL
Richard A. Haack - Chicago IL
Stella S. Yu - Morton Grove IL

Assignee:

G. D. Searle & Co. - Chicago IL

International Classification:

A61K 31165
C07C23300

US Classification:

514621

Abstract:

This invention relates to a compound of the formula: ##STR1## or a pharmaceutically acceptable salt thereof wherein X is oxygen, sulfur, or --CH. dbd. CH--; wherein Z is OR. sup. 1 or --NR. sup. 4 R. sup. 5 ; wherein R. sup. 1 is hydrogen, lower alkyl, or a pharmaceutically acceptable cation; wherein R. sup. 2 is H, --CH. sub. 3 or --C. sub. 2 H. sub. 5 ; wherein R. sup. 3 is OH, H or. dbd. O; wherein R. sup. 4 and R. sup. 5 may independently be hydrogen, or lower alkyl having 1-6 carbon atoms, or R. sup. 4 and R. sup. 5 may act together with N to form a cyclic amide of the formula: ##STR2## wherein n is an integer from 4-5; and m is an integer from 0-4. More particularly, this invention relates to compounds of the above formula which have utility as LTB. sub. 4 antagonists.

US Patent:

59523816, Sep 14, 1999

Filed:

Mar 27, 1997

Appl. No.:

8/826244

Inventors:

Barbara B. Chen - Glenview IL
Helen Y. Chen - Livingston NJ
Glen J. Gesicki - Morton Grove IL
Richard A. Haack - Chicago IL
James W. Malecha - Libertyville IL
Thomas D. Penning - Elmhurst IL
Joseph G. Rico - Ballwin MO
Thomas E. Rogers - Ballwin MO
Peter G. Ruminski - Ballwin MO
Mark A. Russell - Gurnee IL
Stella S. Yu - Morton Grove IL

Assignee:

G. D. Searle & Co. - Chicago IL

International Classification:

C07C22900
C07C20500
A61K 3119

US Classification:

514565

Abstract:

The present invention relates to a class of compounds represented by Formula I ##STR1## or a pharmaceutically acceptable salt thereof, pharmaceutical composition comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the. alpha. sub. v. beta. sub. 3 integrin.

US Patent:

48958697, Jan 23, 1990

Filed:

Jun 3, 1988

Appl. No.:

7/202279

Inventors:

Stevan W. Djuric - Glenview IL
Richard A. Haack - Chicago IL
Julie M. Miyashiro - Evanston IL

Assignee:

C. D. Searle & Co. - Chicago IL

International Classification:

A61K 338
C07D33322

US Classification:

514438

Abstract:

This invention related to leukotriene B. sub. 4 antagonists having the structure ##STR1## and the pharmaceutically acceptable addition salts thereof; wherein R. sup. 1 is lower alkyl having 1-10 carbon atoms; or lower alkenyl or alkynyl having 2-10 carbon atoms; or lower alkadienyl having 3-10 carbon atoms; or lower alkadienyl or alkenynyl having 4-10 carbon atoms; wherein R. sup. 2 and R. sup. 3 are the same or different and represent hydrogen or lower alkyl having 1-6 carbon atoms; wherein X is CH. dbd. CH, S, or O; wherein Y is CH. dbd. CH or C. tbd. C; wherein Z is OR. sup. 4 or NR. sup. 5 R. sup. 6, and wherein R. sup. 4 represents H, lower alkyl having 1-6 carbon atoms, or a pharmaceutically acceptable cation, and wherein R. sup. 5 and R. sup. 6 act independently and represent H or lower alkyl having 1-6 carbon atoms, or R. sup. 5 and R. sup. 6 may act together with N to form a cycloamine of the formula: ##STR2## wherein q is an integer from 2-5; wherein m and n are the same or different and either 1 or 0; and wherein p is an integer from 1 to 5.

US Patent:

52179818, Jun 8, 1993

Filed:

Oct 27, 1992

Appl. No.:

7/967296

Inventors:

Stevan W. Djuric - Glenview IL
Richard A. Haack - Chicago IL
Julie M. Miyashiro - Chicago IL

Assignee:

G. D. Searle & Co. - Chicago IL

International Classification:

A61K 3144
C07D21172
C07D21184

US Classification:

514340

Abstract:

This invention relates to a compound of the formula ##STR1## or a pharmaceutically acceptable salt thereof wherein X is oxygen, sulfur, --CH. dbd. CH--or --CH. dbd. N--; wherein R. sub. 1 is alkyl, alkenyl or alkynyl of about 1 to 20 carbon atoms; wherein R is --CO. sub. 2 R. sup. 2, tetrazole, methylsulfonamide or benzenesulfonamide, wherein R. sup. 2 is hydrogen, alkyl of 1 to 6 carbon atoms or a pharmaceutically acceptable cation and R. sup. 3 is hydroxyl or halogen, having utility as LTB. sub. 4 synthesis inhibitors.

US Patent:

61462934, Nov 14, 2000

Filed:

Jul 10, 1996

Appl. No.:

8/677776

Inventors:

Kevin S. Chinn - Skokie IL
Richard A. Haack - Chicago IL

International Classification:

A63B 7100

US Classification:

473588

Abstract:

A hockey puck having a cavity and a self leveling weight disposed therein for causing the puck to topple from its side to a face when rolling and for maintaining a face of the puck substantially parallel to the playing surface.

US Patent:

57736464, Jun 30, 1998

Filed:

Mar 27, 1997

Appl. No.:

8/825086

Inventors:

Nizal Chandrakumar - Vernon Hills IL
Barbara B. Chen - Glenview IL
Helen Y. Chen - Livingston NJ
Michael Clare - Sokie IL
Alan F. Gasiecki - Vernon Hills IL
Richard A. Haack - Chicago IL
James W. Malecha - Libertyville IL
Peter G. Ruminski - Ballwin MO
Mark A. Russell - Gurnee IL

Assignee:

G. D. Searle & Co. - Chicago IL

International Classification:

C07C24100
C07C32100
C07C20500
C07C22900

US Classification:

562439

Abstract:

The present invention relates to a class of compounds represented by the Formula I ##STR1## or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the. alpha. sub. v. beta. sub. 3 integrin.