Richard A Knazek

US Patent:

RE40862, Jul 21, 2009

Filed:

Oct 16, 2006

Appl. No.:

11/581734

Inventors:

Mary R. Flack - Ann Arbor MI, US
Richard Knazek - Mount Airy MD, US
Marcus Reidenberg - Scarsdale NY, US

Assignee:

The United States of America as represented by the Department of Health and Human Services - Washington DC

International Classification:

A61K 31/12

US Classification:

514682, 514700

Abstract:

A method for treating cancer in a human, which comprises administering to the human subject an anti-cancer effective amount of a compound selected from gossypol, gossypol acetic acid, gossypolone, metabolites thereof, or physiologically acceptable salts thereof. Also included is a method for treating cancer in a human which comprises administering to the human subject an anti-cancer effective amount of any of the compounds listed above in combination with an anti-cancer effective amount of other conventional chemotherapeutic agents. Finally, the invention also encompasses a pharmaceutical composition comprising an anti-cancer effective amount of gossypol, gossypol acetic acid, or gossypolone, and an anti-cancer effective amount of a conventional chemotherapeutic agent, or combinations of the latter.

US Patent:

53859367, Jan 31, 1995

Filed:

Jul 12, 1990

Appl. No.:

7/551353

Inventors:

Mary R. Flack - Kensington MD
Richard Knazek - Bethesda MD
Marcus Reidenberg - Scarsdale NY

Assignee:

The United States of America as represented by the Secretary of the
Department of the Health and Human Services - Washington DC

International Classification:

A61K 31225
A61K 3119

US Classification:

514548

Abstract:

A method for treating cancer in a human, which comprises administering to the human subject an anti-cancer effective amount gossypol acetic acid. Also included is a method for treating cancer in a human which comprises administering to the human subject an anti-cancer effective amount of gossypol acetic acid in combination with an anti-cancer effective amount of other conventional chemotherapeutic agents. Finally, the invention also encompasses a pharmaceutical composition comprising an anti-cancer effective amount of gossypol acetic acid, and an anti-cancer effective amount of a conventional chemotherapeutic agent, or combinations of the latter.

US Patent:

61143979, Sep 5, 2000

Filed:

Jan 27, 1995

Appl. No.:

8/379872

Inventors:

Mary R. Flack - Kensington MD
Richard Knazek - Bethesda MD
Marcus Reidenberg - Scarsdale NY

Assignee:

The United States of America as represented by the Department of Health
and Human Services - Washington DC

International Classification:

A61K 3112
A61K 3111

US Classification:

514682

Abstract:

A method for treating cancer in a human, which comprises administering to the human subject an anti-cancer effective amount of a compound selected from gossypol, gossypol acetic acid, gossypolone, metabolites thereof, or physiologically acceptable salts thereof. Also included is a method for treating cancer in a human which comprises administering to the human subject an anti-cancer effective amount of any of the compounds listed above in combination with an anti-cancer effective amount of other conventional chemotherapeutic agents. Finally, the invention also encompasses a pharmaceutical composition comprising an anti-cancer effective amount of gossypol, gossypol acetic acid, or gossypolone, and an anti-cancer effective amount of a conventional chemotherapeutic agent, or combinations of the latter.

US Patent:

42006899, Apr 29, 1980

Filed:

Aug 29, 1978

Appl. No.:

5/937762

Inventors:

Richard A. Knazek - Bethesda MD
Pietro M. Gullino - Bethesda MD
David S. Frankel - Newark DE

Assignee:

United States of America - Washington DC

International Classification:

A01N 102

US Classification:

435 2

Abstract:

A method for cell culture using an artificial capillary cell culture device having two separate perfusion circuits, and with the ultrafiltration fibers of the two circuits being woven into a single bundle. The present device provides a maxtrix for high density growth of cultured cells in a continuous perfusion system. The device is particularly well adapted for the use of pressure differences between perfusion circuits,, such as in the simulation of lymphatic drainage.

US Patent:

42207258, Sep 2, 1980

Filed:

Apr 3, 1978

Appl. No.:

5/892853

Inventors:

Richard A. Knazek - Bethesda MD
Pietro M. Gullino - Bethesda MD

Assignee:

United States of America - Washington DC

International Classification:

C12M 304

US Classification:

435285

Abstract:

The growth of cells within a device containing a bundle of semi-permeable, tubular capillaries is disclosed. The bundle of capillaries is wrapped in an envelope of porous sheet material, thus creating an extra-envelope space into which the cells can migrate for periodic removal without disturbing the main culture within the capillaries. Porous capillaries may also be employed, in place of or in addition to the porous envelope.

US Patent:

42060150, Jun 3, 1980

Filed:

Aug 29, 1978

Appl. No.:

5/937761

Inventors:

Richard A. Knazek - Bethesda MD
Pietro M. Gullino - Bethesda MD
David S. Frankel - Newark DE

Assignee:

United States of America - Washington DC

International Classification:

A01N 102

US Classification:

435 2

Abstract:

A method for simulation of lymphatic drainage using artificial capillary cell culture device having two separate perfusion circuits, and with the ultrafiltration fibers of the two circuits being woven into a single bundle. The present device provides a matrix for high density growth of cultured cells in a continuous perfusion system. The device is particularly well adapted for the use of pressure differences between perfusion circuits.

US Patent:

54985374, Mar 12, 1996

Filed:

Mar 9, 1994

Appl. No.:

8/208520

Inventors:

Herbert S. Bresler - Silver Spring MD
Richard A. Knazek - Mount Airy MD

Assignee:

Cellco, Inc. - Germantown MD

International Classification:

C12N 510
C12N 700
C12N 701

US Classification:

4352351

Abstract:

The application concerns a method for the serum-free production of packaged and infectious vital vectors in an artificial capillary system cartridge. The invention further concerns transducing target cells with the vital vectors. The invention is particularly suitable for producing transduced target cells free of adherent serum proteins.

US Patent:

41849221, Jan 22, 1980

Filed:

Nov 11, 1977

Appl. No.:

5/850810

Inventors:

Richard A. Knazek - Bethesda MD
Pietro M. Gullino - Bethesda MD
David S. Frankel - Newark DE

Assignee:

The Government of the United States - Washington DC

International Classification:

C12K 110
C12K 900

US Classification:

435284

Abstract:

An artificial capillary cell culture device having two separate perfusion circuits, and with the ultrafiltration fibers of the two circuits being woven into a single bundle, is disclosed. The present device provides a matrix for high density growth of cultured cells in a continuous perfusion system. The device is particularly well adapted for the use of pressure differences between perfusion circuits, such as in the simulation of lymphatic drainage.