Richard A Kramer

US Patent:

8114843, Feb 14, 2012

Filed:

Nov 17, 2006

Appl. No.:

11/601591

Inventors:

Ehud Y. Isacoff - Berkeley CA, US
Richard H. Kramer - Oakland CA, US
Dirk Trauner - San Francisco CA, US
Matthew Banghart - Oakland CA, US
Matthew Volgraf - Oakland CA, US
Pablo Ignacio Gorostiza Langa - Barcelona, ES
Katharine Borges - Centerport NY, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

C07K 14/705
A61K 38/00

US Classification:

514 173, 514 174, 514 2, 549540

Abstract:

The present invention provides a synthetic regulator of protein function, which regulator is a light-sensitive regulator. The present invention further provides a light-regulated polypeptide that includes a subject synthetic regulator. Also provided are cells and membranes comprising a subject light-regulated polypeptide. The present invention further provides methods of modulating protein function, involving use of light. The present invention further provides methods of identifying agents that modulate protein function.

US Patent:

8309350, Nov 13, 2012

Filed:

Feb 1, 2012

Appl. No.:

13/364105

Inventors:

Ehud Y. Isacoff - Berkeley CA, US
Richard H. Kramer - Oakland CA, US
Dirk Trauner - Munich, DE
Matthew R. Banghart - Oakland CA, US
Matthew Volgraf - Oakland CA, US
Pablo Ignacio Gorostiza Langa - Barcelona, ES
Katharine Borges - Centerport NY, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

C12N 5/00
A61K 38/00

US Classification:

435325, 514 173, 514 174, 549540, 435 72, 435 41

Abstract:

The present invention provides a synthetic regulator of protein function, which regulator is a light-sensitive regulator. The present invention further provides a light-regulated polypeptide that includes a subject synthetic regulator. Also provided are cells and membranes comprising a subject light-regulated polypeptide. The present invention further provides methods of modulating protein function, involving use of light. The present invention further provides methods of identifying agents that modulate protein function.

US Patent:

20110207213, Aug 25, 2011

Filed:

Oct 29, 2009

Appl. No.:

13/059052

Inventors:

Dirk Trauner - Munich, DE
Ehud Y. Isacoff - Berkeley CA, US
Richard H. Kramer - Oakland CA, US
Matthew R. Banghart - Oakland CA, US
Doris L. Fortin - Ottawa, CA
Alexandre Mourot - Berkeley CA, US

International Classification:

C12N 5/071
C09B 44/02
C09B 46/00
C07K 2/00

US Classification:

435325, 534603, 534573, 530300

Abstract:

The present disclosure provides a photoreactive synthetic regulator of protein function. The present disclosure further provides a light-regulated polypeptide that includes a subject synthetic regulator. Also provided are cells and membranes comprising a subject light-regulated polypeptide. The present disclosure further provides methods of modulating protein function, involving use of light.

US Patent:

20130137113, May 30, 2013

Filed:

Nov 8, 2012

Appl. No.:

13/671908

Inventors:

The Regents of the University of California - Oakland CA, US
Richard H. Kramer - Oakland CA, US
Dirk Trauner - Munich, DE
Matthew R. Banghart - Oakland CA, US
Matthew Volgraf - Oakland CA, US
Pablo Ignacio Gorostiza Langa - Barcelona, SP
Katharine Borges - Centerport NY, US

Assignee:

THE REGENTS OF THE UNIVERSITY OF CALIFORNIA - Oakland CA

International Classification:

G01N 33/53

US Classification:

435 71

Abstract:

The present invention provides a synthetic regulator of protein function, which regulator is a light-sensitive regulator. The present invention further provides a light-regulated polypeptide that includes a subject synthetic regulator. Also provided are cells and membranes comprising a subject light-regulated polypeptide. The present invention further provides methods of modulating protein function, involving use of light. The present invention further provides methods of identifying agents that modulate protein function.

US Patent:

20160229794, Aug 11, 2016

Filed:

Apr 19, 2016

Appl. No.:

15/132553

Inventors:

- Oakland CA, US
Ehud Y. Isacoff - Berkeley CA, US
Richard H. Kramer - Oakland CA, US
Matthew R. Banghart - Oakland CA, US
Doris L. Fortin - Ottawa, CA
Alexandre Mourot - Berkeley CA, US

International Classification:

C07C 245/08
C07K 14/705
C12N 13/00

Abstract:

The present disclosure provides a photoreactive synthetic regulator of protein function. The present disclosure further provides a light-regulated polypeptide that includes a subject synthetic regulator. Also provided are cells and membranes comprising a subject light-regulated polypeptide. The present disclosure further provides methods of modulating protein function, involving use of light.

US Patent:

20150224193, Aug 13, 2015

Filed:

Jan 8, 2015

Appl. No.:

14/592646

Inventors:

- Oakland CA, US
Richard H. Kramer - Oakland CA, US
Dirk Trauner - Munich, DE
Matthew R. Banghart - Boston MA, US
Matthew Volgraf - Oakland CA, US
Pablo Ignacio Gorostiza Langa - Barcelona, ES
Katharine Borges - Centerport NY, US

International Classification:

A61K 41/00
C12N 5/079
A61N 5/06
C12N 13/00

Abstract:

The present invention provides a synthetic regulator of protein function, which regulator is a light-sensitive regulator. The present invention further provides a light-regulated polypeptide that includes a subject synthetic regulator. Also provided are cells and membranes comprising a subject light-regulated polypeptide. The present invention further provides methods of modulating protein function, involving use of light. The present invention further provides methods of identifying agents that modulate protein function.

US Patent:

20150158811, Jun 11, 2015

Filed:

Feb 19, 2015

Appl. No.:

14/626124

Inventors:

- Oakland CA, US
Ehud Y. Isacoff - Berkeley CA, US
Richard H. Kramer - Oakland CA, US
Matthew R. Banghart - Oakland CA, US
Doris L. Fortin - Ottawa, CA
Alexandre Mourot - Berkeley CA, US

International Classification:

C07C 245/08

Abstract:

The present disclosure provides a photoreactive synthetic regulator of protein function. The present disclosure further provides a light-regulated polypeptide that includes a subject synthetic regulator. Also provided are cells and membranes comprising a subject light-regulated polypeptide. The present disclosure further provides methods of modulating protein function, involving use of light.