Richard H Malavarca

US Patent:

20130137176, May 30, 2013

Filed:

Jul 1, 2011

Appl. No.:

13/807260

Inventors:

Marsha Lynn Roach - Bradford CT, US
Richard Harold Malavarca - Long Valley NJ, US
Yunfang Wang - Beijing, CN
Lola Cynthia McAdams Reid - Chapel Hill NC, US

Assignee:

The University of North Carolina at Chapel Hill - Chapel Hill NC

International Classification:

C12N 5/071

US Classification:

435377

Abstract:

The present invention provides biomatrix scaffolds for industrial scale dispersal.

US Patent:

46184082, Oct 21, 1986

Filed:

Nov 29, 1984

Appl. No.:

6/675984

Inventors:

Richard Malavarca - South Orange NJ
Thomas Livelli - Lyndhurst NJ

Assignee:

Lab Stuff, Inc. - South Orange NJ

International Classification:

G01N 2728

US Classification:

204299R

Abstract:

A casting apparatus for receiving electrophoretic gel trays is disclosed. The casting apparatus includes a pair of spaced apart seal elements which are movable with respect to one another to provide one or, more openings of varying size to receive a corresponding gel tray therein. The open ends of the gel tray are sealed by the seal elements so that hot argrose or polyacrylamide gel may be poured into the gel tray for forming a gel layer of predetermined thickness. The seal elements are maintained in sealing engagement with the open ends of the gel trays by means of a rod frictionally engaged between a portion of the housing forming the casting apparatus and one of the seal elements.

US Patent:

D2905108, Jun 23, 1987

Filed:

Nov 29, 1984

Appl. No.:

6/675989

Inventors:

Richard Malavarca - South Orange NJ
Thomas Livelli - Lyndhurst NJ

Assignee:

Lab Stuff, Inc. - South Orange NJ

US Classification:

D24 31

US Patent:

48289876, May 9, 1989

Filed:

May 14, 1984

Appl. No.:

6/609923

Inventors:

John J. Kopchick - Verona NJ
Frederick C. Leung - Scotch Plains NJ
Thomas J. Livelli - Lyndhurst NJ
Richard H. Malavarca - South Orange NJ

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

C12P 2100
C12P 1934
C12N 1500
C12N 700

US Classification:

435 68

Abstract:

Recombinant DNA molecules in which an avian retroviral long terminal repeat (LTR) has been ligated to the bovine growth hormone gene are described herein. The retroviral LTR was derived from a plasmid clone of a Schmidt Rupin strain of Rous Sarcoma Virus while the bovine growth hormone (BGH) gene was derived from a lambda-bacteriophage genomic library. Using a transient eucaryotic expression assay system, the plasmid constructs were screened for their ability to direct expression and secretion of bovine growth hormone. These constructs were co-transformed into a mammalian cell (mouse) culture in order to obtain a stable cell culture secreting large amounts of bovine growth hormone.

US Patent:

46860983, Aug 11, 1987

Filed:

May 14, 1984

Appl. No.:

6/609924

Inventors:

John J. Kopchick - Verona NJ
Frederick C. Leung - Scotch Plains NJ
Thomas J. Livelli - Lyndhurst NJ
Richard H. Malavarca - South Orange NJ

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

A61K 944
A01N 2510
C12N 1102
C12N 1104

US Classification:

424 15

Abstract:

Recombinant DNA constructs having an avian retroviral long terminal repeat (LTR) ligated to the bovine growth hormone gene, were co-transformed into a mammalian cell (mouse) culture in order to obtain a stable cell culture secreting large amounts of bovine growth hormone. The transformed mouse cells were encapsulated in hollow fibers and implanted into animals, thereby producing circulating bovine growth hormone.

US Patent:

20200010806, Jan 9, 2020

Filed:

Jan 24, 2018

Appl. No.:

16/482666

Inventors:

- Branford CT, US
Richard Harold Malavarca - Long Valley NJ, US
Shiloh Jesse Barfield - Cary NC, US

Assignee:

PhoenixSongs Biologicals, Inc. - Branford CT

International Classification:

C12N 5/071

Abstract:

Provided are methods and compositions for co-culturing hepatocytes in the presence of growth-arrested stromal cells, resulting in maintenance of hepatocyte function and phenotype for an extended period of time in culture comprising at least 30 days.

US Patent:

20190024043, Jan 24, 2019

Filed:

Apr 12, 2018

Appl. No.:

15/952094

Inventors:

- Chapel Hill NC, US
Richard Harold MALAVARCA - Long Valley NJ, US
Yunfang WANG - Beijing, CN
Lola M. REID - Chapel Hill NC, US

Assignee:

The University of North Carolina at Chapel Hill - Chapel Hill NC

International Classification:

C12N 5/00
C12N 5/071
A61L 27/36
C12N 7/00
A61L 27/24
C12N 5/09

Abstract:

The present invention provides biomatrix scaffolds for industrial scale dispersal.