Richard L Mathias

US Patent:

20200324097, Oct 15, 2020

Filed:

Jun 23, 2020

Appl. No.:

16/909723

Inventors:

- St. Paul MN, US
Chin-Yee NG - Oakdale MN, US
Michael J. FRITS - Lake Elmo MN, US
Richard R. MATHIAS - Brookline MA, US

International Classification:

A61M 37/00
A61M 5/142
A61M 5/32

Abstract:

A microneedle injection and infusion apparatus, and a method of using same. The apparatus can include a housing, a microneedle array holder for holding a microneedle array, and a shuttle that holds a cartridge (e.g., that contains an active agent). The microneedle array holder can be movable between a retracted position and an extended position. The shuttle can be movable between a first position in which the cartridge is not in fluid communication with a fluid path and a second position in which the cartridge is in fluid communication with the fluid path. The apparatus can further include an actuator movable between a first position and a second position. The method can include moving the actuator to its second position to allow the shuttle to move toward its second position, wherein movement of the shuttle toward its second position allows the microneedle array holder to move to its extended position.

US Patent:

20200289808, Sep 17, 2020

Filed:

Oct 17, 2018

Appl. No.:

16/754881

Inventors:

- SAINT PAUL MN, US
MICHAEL J. FRITS - LAKE ELMO MN, US
STEVEN P. GOWERS - CAMBRIDGE, GB
GREGORY R. LEY - BLAINE MN, US
RICHARD R. MATHIAS - BROOKLINE MA, US
ROBERT G. M. SELBY - HERTFORDSHIRE, GB
RYAN PATRICK SIMMERS - FARGO MN, US
MICHAEL B. SIVIGNY - LAKE ELMO MN, US
DANIEL G.T. STRANGE - CAMBRIDGE, GB

Assignee:

KINDEVA DRUG DELIVERY L.P. - SAINT PAUL MN

International Classification:

A61M 37/00

Abstract:

An applicator and method for applying a microneedle array to skin. The applicator can include a body having a first portion and a second portion defining a cavity, the second portion having a slot presented on an outside surface for insertion of the microneedle array into the cavity. The first portion and the second portion are slidable relative to one other along an axis enabling the body to be in an unprimed configuration and a primed configuration. The applicator further includes a door operable with the second portion, the door being movable from a first door position to a second door position, wherein when the device is in the unprimed configuration, the door at least partially obstructs the slot and access into the cavity. When the device is in the primed configuration, the door does not obstruct the slots and enables access into the cavity.

US Patent:

20180140816, May 24, 2018

Filed:

Jan 10, 2018

Appl. No.:

15/866526

Inventors:

- St. Paul MN, US
CHIN-YEE NG - OAKDALE MN, US
RICHARD R. MATHIAS - BROOKLINE MA, US
THOMAS D.R. FORD - WELLESLEY MA, US

International Classification:

A61M 37/00
A61M 5/24
A61M 5/32

Abstract:

A microneedle injection apparatus comprising a dual cover. The apparatus can include a housing having a base and a cavity; a microneedle array comprising a first side comprising a plurality of microneedles; and a microneedle array holder configured to hold a microneedle array and located in the housing. The microneedle array holder can be movable between a retracted position, and an extended position. The apparatus can further include a cover configured to be positioned to cover the opening in the base of the housing. The cover can include (i) a first portion configured to cover at least a portion of the base of the housing adjacent the opening, and (ii) a second portion configured to be received in the cavity of the housing and further configured to cover the plurality of microneedles on the microneedle array when the microneedle array holder is in the retracted position.

US Patent:

20180110970, Apr 26, 2018

Filed:

Dec 12, 2017

Appl. No.:

15/838542

Inventors:

- St. Paul MN, US
Chin-Yee Ng - Oakdale MN, US
Michael J. Frits - Lake Elmo MN, US
Richard R. Mathias - Brookline MA, US

International Classification:

A61M 37/00
A61M 5/32
A61M 5/142

Abstract:

A microneedle injection and infusion apparatus, and a method of using same. The apparatus can include a housing, a microneedle array holder for holding a microneedle array, and a shuttle that holds a cartridge (e.g., that contains an active agent). The microneedle array holder can be movable between a retracted position and an extended position. The shuttle can be movable between a first position in which the cartridge is not in fluid communication with a fluid path and a second position in which the cartridge is in fluid communication with the fluid path. The apparatus can further include an actuator movable between a first position and a second position. The method can include moving the actuator to its second position to allow the shuttle to move toward its second position, wherein movement of the shuttle toward its second position allows the microneedle array holder to move to its extended position.

US Patent:

20170252547, Sep 7, 2017

Filed:

May 17, 2017

Appl. No.:

15/597235

Inventors:

- St. Paul MN, US
Chin-Yee Ng - Oakdale MN, US
Richard R. Mathias - Boston MA, US

Assignee:

3M INNOVATIVE PROPERTIES COMPANY - St. Paul MN

International Classification:

A61M 37/00
A61M 5/32

Abstract:

A microneedle injection apparatus comprising an inverted actuator. The apparatus can include a housing having a base and a cavity, and a microneedle array holder configured to hold a microneedle array within the cavity of the housing. The microneedle array holder can be movable between a retracted position, and an extended position. The apparatus can further include an actuator movable with respect to the housing and the microneedle array holder between a first position and a second position to cause the microneedle array holder to move from the retracted position to the extended position. At least a portion of the actuator can be located on a skin-facing side of the apparatus (e.g., adjacent the base of the housing) and can be configured to be moved from the first position to the second position in response to the apparatus being pressed toward the skin surface.

US Patent:

20160121091, May 5, 2016

Filed:

May 22, 2014

Appl. No.:

14/892265

Inventors:

- Saint Paul MN, US
Chin-Yee Ng - Oakdale MN, US
Richard R. Mathias - Boston MA, US
Thomas D. R. Ford - Wellesley MA, US

Assignee:

3M INNOVATIVE PROPERTIES COMPANY - St. Paul MN

International Classification:

A61M 37/00

Abstract:

A microneedle injection apparatus comprising a dual cover. The apparatus can include a housing having a base and a cavity; a microneedle array comprising a first side comprising a plurality of microneedles; and a microneedle array holder configured to hold a microneedle array and located in the housing. The microneedle array holder can be movable between a retracted position, and an extended position. The apparatus can further include a cover () configured to be positioned to cover the opening () in the base () of the housing. The cover can include (i) a first portion () configured to cover at least a portion of the base of the housing adjacent the opening, and (ii) a second portion () configured to be received in the cavity of the housing and further configured to cover the plurality of microneedles on the microneedle array when the microneedle array holder is in the retracted position.

US Patent:

20160082241, Mar 24, 2016

Filed:

May 22, 2014

Appl. No.:

14/892238

Inventors:

- Saint. Paul MN, US
Chin-Yee Ng - Oakdale MN, US
Richard R. Mathias - Boston MA, US

International Classification:

A61M 37/00
A61M 5/32

Abstract:

A microneedle injection apparatus () comprising an inverted actuator. The apparatus can include a housing () having a base and a cavity, and a microneedle array holder () configured to hold a microneedle array () within the cavity of the housing. The microneedle array holder can be movable between a retracted position, and an extended position. The apparatus can further include an actuator () movable with respect to the housing and the microneedle array holder between a first position and a second position to cause the microneedle array holder to move from the retracted position to the extended position. At least a portion of the actuator can be located on a skin-facing side of the apparatus (e.g., adjacent the base of the housing) and can be configured to be moved from the first position to the second position in response to the apparatus being pressed toward the skin surface.

US Patent:

20160082242, Mar 24, 2016

Filed:

May 22, 2014

Appl. No.:

14/892249

Inventors:

- Saint Paul MN, US
Chin-Yee Ng - Oakdale MN, US
Michael J. Frits - Lake Elmo MN, US
Richard R. Mathias - Boston MA, US

International Classification:

A61M 37/00
A61M 5/32

Abstract:

A microneedle injection and infusion apparatus, and a method of using same. The apparatus () can include a housing (), a microneedle array holder () for holding a microneedle array (), and a shuttle () that holds a cartridge (e.g., that contains an active agent). The microneedle array holder can be movable between a retracted position and an extended position. The shuttle can be movable between a first position in which the cartridge is not in fluid communication with a fluid path and a second position in which the cartridge is in fluid communication with the fluid path. The apparatus can further include an actuator () movable between a first position and a second position. The method can include moving the actuator to its second position to allow the shuttle to move toward its second position, wherein movement of the shuttle toward its second position allows the microneedle array holder to move to its extended position.