Richard J Mcclure

US Patent:

7632662, Dec 15, 2009

Filed:

Jul 31, 2008

Appl. No.:

12/183609

Inventors:

Jay W. Pettegrew - Pittsburgh PA, US
Kanagasabai Panchalingam - Monroeville PA, US
Richard J. McClure - Pittsburgh PA, US

International Classification:

C12P 21/02

US Classification:

435 701, 514548, 514556

Abstract:

Carnitines are nutraceuticals with indications in treating a variety of mental health disorders. A metabolomics-guided bioprocess method is presented to produce longer chain fatty acid esters of carnitines such as polyunsaturated fatty acid esters including eicosapentaenoyl-L-carnitine and/or docosahexaenyl-L-carnitine in germinating plant seeds. The resulting products from the plant seeds are used as a natural nutritional source of powerful human antioxidants.

US Patent:

7815894, Oct 19, 2010

Filed:

May 27, 2004

Appl. No.:

10/854894

Inventors:

Jay W. Pettegrew - Pittsburgh PA, US
Richard J. McClure - Pittsburgh PA, US
Kanagasabai Panchalingam - Monroeville PA, US
Billy W. Day - Pittsburgh PA, US

International Classification:

A61K 51/00
A61M 36/14

US Classification:

424 177, 424 111, 424 165, 424 181, 424 185, 424 189, 424 91, 424 92, 424 93, 424 94

Abstract:

Compounds, compositions and methods for the diagnosis of Alzheimer's disease. Synthesized Glycerophosphocholine (GPC) may be used as a diagnostic aid to measure progression of Alzheimer's disease. GPC is a membrane phospholipid metabolite that is capable of binding specifically to the β-turn of beta amyloid (Aβ) peptide. Compounds including non-radioactive, paramagnetic, and radioactive derivatives of GPC are presented. These compounds possess similar binding properties to original GPC molecules and are useful in medical magnetic resonance imaging and/or positron emission tomography applications. By employing these radiological techniques in conjunction with the compositions of the present invention, the diagnosis and assessment of the progression of Alzheimer's disease may be achieved.

US Patent:

8329142, Dec 11, 2012

Filed:

Jul 23, 2008

Appl. No.:

12/178281

Inventors:

Jay W. Pettegrew - Pittsburgh PA, US
Richard J. McClure - Pittsburgh PA, US
Kanagasabai Panchalingam - Monroeville PA, US

International Classification:

A61K 51/00
A61M 36/14

US Classification:

424 189, 424 111, 424 165, 424 181, 424 185, 424 91

Abstract:

Compounds, compositions and methods for the detection and diagnosis of Parkinson's disease. Derivative lycerophosphocholine (GPC) compounds are used as a detection and diagnostic aid to measure progression of Parkinson's disease by detecting GPC binding to α-synuclein. Derivative CPG compounds including non-radioactive, paramagnetic, and radioactive derivatives of GPC are presented. These compounds possess similar binding properties to original GPC molecules and are useful in medical magnetic resonance imaging (MRI) and/or positron emission tomography (PET) applications. By employing these radiological techniques in conjunction with the compositions of the present invention, the detection, diagnosis and assessment of the progression of Parkinson's disease may be achieved.

US Patent:

20060257842, Nov 16, 2006

Filed:

Apr 21, 2006

Appl. No.:

11/409395

Inventors:

Jay Pettegrew - Pittsburgh PA, US
Thomas Glonek - Oak Park IL, US
Richard McClure - Pittsburgh PA, US
Kanagasabai Panchalingam - Monroeville PA, US

International Classification:

A01N 1/02
A01N 1/00

US Classification:

435001100, 435002000

Abstract:

The cryopreservation media utilizes naturally occurring endogenous molecules and their chemical derivatives which act as osmotically active cryopreservative agents as well as molecules which insert into and protect specific regions of cellular membranes, lead to membrane repair, maintain normal cellular levels of energy metabolites, and act as antioxidants. Cryoperserved cells can be returned to a pre- cryopreservation state without damaging the cells resulting in a very high survival rate.

US Patent:

20210381758, Dec 9, 2021

Filed:

Feb 17, 2021

Appl. No.:

17/177763

Inventors:

- Denver CO, US
Richard F. McClure - Golden CO, US

Assignee:

Carbon Vault LLC - Denver CA

International Classification:

F25J 1/00
B01D 53/00

Abstract:

Systems and methods to separate carbon dioxide from flue gases and sequester carbon dioxide are described here. By using the properties of carbon dioxide and the temperature in a body of water (e.g., the ocean or freshwater body of water) or the temperatures of the ambient atmosphere, gaseous carbon dioxide can be converted to a liquid and separated from other gases. Pressure used to separate carbon dioxide from other gases may also be used to sequester liquid carbon dioxide. The liquid carbon dioxide is inert and can be discharged into the ocean without dissolving in seawater and acidifying the ocean. The liquid carbon dioxide may further be densified to be denser than seawater. The liquid carbon dioxide can then sink to the bottom of the ocean or be injected into ocean sediments or sediments and rocks beneath the ocean floor, inert and sequestered for the long term.