Richard G Osifchin from Bernardsville, NJ, age 60

5-Chloro-3-(4-Methanesulfonylphenyl)-6Â²-Methyl-[2,3Â²]Bipyridinyl In Pure Crystalline Form And Process For Synthesis
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US Patent:

6673935, Jan 6, 2004
Filed:

Jan 14, 2003
Appl. No.:

10/342380
Inventors:

Louis S. Crocker - Belle Mead NJ
Ian W. Davies - Princeton NJ
Richard G. Osifchin - Watchung NJ
Andrew Kotliar - Hoboken NJ
Assignee:

Merck Co., Inc. - Rahway NJ
International Classification:

C07D21322
US Classification:

546257
Abstract:

This invention encompasses the Form V polymorph of Compound A of structural formula: which is useful in the treatment of cyclooxygenase-2 mediated diseases. The invention encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising the Form V polymorph of Compound A. The invention also encompasses a process for synthesizing the Form V polymorph of Compound A.

5-Chloro-3-(4-Methanesulfonylphenyl)-6-Methyl-[2,3]Bipyridinyl In Pure Crystalline Form And Process For Synthesis
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US Patent:

6800647, Oct 5, 2004
Filed:

Sep 21, 2001
Appl. No.:

09/957966
Inventors:

Loius S. Crocker - Belle Mead NJ
Ian W. Davies - Princeton NJ
Richard G. Osifchin - Watchung NJ
Andrew Kotliar - Hoboken NJ
Assignee:

Merck Co., Inc. - Rahway NJ
International Classification:

A61K 3144
US Classification:

514334, 5462681
Abstract:

This invention encompasses a pharmaceutical composition comprising the compound of formula A: in combination with a pharmaceutically acceptable carrier, said compound being comprised of about 1-50%, 1-20% or 1-10% of the polymorphic form which is designated Form V and the remainder of the compound being comprised of at least one polymorphic form selected from the group consisting of: Form I, Form II, Form III and Form IV.

5-Chloro-3-(4-Methanesulfonylphenyl)-6'-Methyl-[2,3']Bipyridinyl In Pure Crystalline Form And Process For Synthesis
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US Patent:

20020016343, Feb 7, 2002
Filed:

May 25, 2001
Appl. No.:

09/865771
Inventors:

Louis Crocker - Belle Mead NJ, US
Ian Davies - Princeton NJ, US
Richard Osifchin - Watchung NJ, US
Andrew Kotliar - Hoboken NJ, US
International Classification:

C 07D 4 1/02
A61K031/444
US Classification:

514/334000, 546/258000
Abstract:

This invention encompasses the Form V polymorph of Compound A of structural formula: which is useful in the treatment of cyclooxygenase-2 mediated diseases. The invention encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising the Form V polymorph of Compound A. The invention also encompasses a process for synthesizing the Form V polymorph of Compound A.

Richard G Osifchin