Richard F Parrish

US Patent:

6887669, May 3, 2005

Filed:

Apr 4, 2000

Appl. No.:

09/542445

Inventors:

Mark A. Staples - San Jose CA, US
Carolyn J. Haley - Morgan Hill CA, US
Richard F. Parrish - San Jose CA, US
Wesley W. Zmolek - Freemont CA, US

Assignee:

Dade Behring Marburg GmbH - Marburg

International Classification:

G01N033/53
G01N033/531
G01N001/18
G01N001/00
G01N033/561

US Classification:

435 71, 435 79, 435961, 435962, 436177, 436174, 436536, 436825, 436501

Abstract:

The present invention relates to a method for releasing a ligand from a complex of the ligand with an endogenous protein using a releasing agent.

US Patent:

7115383, Oct 3, 2006

Filed:

Mar 22, 2004

Appl. No.:

10/806327

Inventors:

Yi Feng Zheng - Wilmington DE, US
Richard F. Parrish - San Jose CA, US
Johnny Valdez - Fremont CA, US

Assignee:

Dade Behring Inc. - Deerfield IL

International Classification:

G01N 33/535
G01N 33/531
C07K 16/00
C07K 17/02

US Classification:

435 79, 435961, 435975, 435 71, 435188, 436544, 436546, 5303889, 5303898, 530402, 530405

Abstract:

Methods, compositions and kits are disclosed. The compounds disclosed comprise an amphetamine moiety and a methamphetamine moiety linked together by a first linking group. A second linking group depends from the first linking group and comprises a functional group. The distance of the amphetamine moiety and the methamphetamine moiety from the point of linkage of the second linking group to the first linking group is approximately the same. The compounds may be linked to labels and used in assays for the detection of amphetamine and/or methamphetamine in samples suspected of containing these drugs.

US Patent:

20050191762, Sep 1, 2005

Filed:

Apr 18, 2005

Appl. No.:

11/108229

Inventors:

Mark Staples - San Jose CA, US
Carolyn Haley - Morgan Hill CA, US
Richard Parrish - San Jose CA, US
Wesley Zmolek - Freemont CA, US

International Classification:

G01N033/543

US Classification:

436518000

Abstract:

One aspect of the present invention relates to a method for releasing a ligand from a complex thereof. The method comprises contacting a medium suspected of containing such complex with an effective amount of a compound effective in releasing the ligand. Another aspect of the present invention is an improvement in a method for the determination of an analyte that is a member of a specific binding pair in a sample suspected of containing such analyte. The method comprises the steps of (a) providing in an assay medium the sample and a binding partner for the analyte and (b) detecting the binding of the binding partner to the analyte. The improvement comprises including in the assay medium a compound of the invention in an amount sufficient to enhance the accuracy of the determination. The invention has particular application to a method for releasing mycophenolic acid from a complex thereof. The method provides an improvement in a method for the determination of mycophenolic acid in a sample suspected of containing mycophenolic acid. The present invention also provides assay reagents as well as packaged kits useful for performing the methods of the invention.

US Patent:

61596981, Dec 12, 2000

Filed:

Jul 17, 1997

Appl. No.:

8/895856

Inventors:

Mark A. Staples - San Jose CA
Richard F. Parrish - San Jose CA

Assignee:

Dade Behring Marburg GmbH - Marburg

International Classification:

G01N 3353
G01N 33531
G01N 33543
G01N 100

US Classification:

435 71

Abstract:

One aspect of the present invention relates to assays for the detection of mycophenolic acid. The method comprises including in an assay medium suspected of containing mycophenolic acid a releasing agent for releasing mycophenolic acid from a complex with endogenous proteins. Another aspect of the present invention is an improvement in a method for the determination of mycophenolic acid in a sample suspected of containing such analyte. The method comprises the steps of (a) providing in combination in an assay medium the sample and a binding partner for the analyte and (b) detecting the binding of the binding partner to the analyte. The improvement comprises including in the assay medium a releasing agent for releasing mycophenolic acid from a complex with endogenous proteins. The present invention also provides assay reagents as well as packaged kits useful for performing the methods of the invention.

US Patent:

61718017, Jan 9, 2001

Filed:

Jul 17, 1997

Appl. No.:

8/896244

Inventors:

Mark A. Staples - San Jose CA
Carolyn J. Haley - Morgan Hill CA
Richard F. Parrish - San Jose CA
Wesley W. Zmolek - Freemont CA

Assignee:

Dade Behring Marburg GmbH - Marburg

International Classification:

G01N 3353
G01N 33531
G01N 118
G01N 100

US Classification:

435 71

Abstract:

One aspect of the present invention relates to a method for releasing a ligand from a complex thereof. The method comprises contacting a medium suspected of containing such complex with an effective amount of a compound effective in releasing the ligand. Another aspect of the present invention is an improvement in a method for the determination of an analyte that is a member of a specific binding pair in a sample suspected of containing such analyte. The method comprises the steps of (a) providing in an assay medium the sample and a binding partner for the analyte and (b) detecting the binding of the binding partner to the analyte. The improvement comprises including in the assay medium a compound of the invention in an amount sufficient to enhance the accuracy of the determination. The invention has particular application to a method for releasing mycophenolic acid from a complex thereof. The method provides an improvement in a method for the determination of mycophenolic acid in a sample suspected of containing mycophenolic acid.