Richard J Proctor

US Patent:

6534548, Mar 18, 2003

Filed:

Oct 2, 2001

Appl. No.:

09/968769

Inventors:

Rae Ellen Syverson - Fond du Lac WI
Richard A. Proctor - Madison WI

Assignee:

Kimberly-Clark Worldwide, Inc. - Neenah WI

International Classification:

A61K 3105

US Classification:

514731, 514967

Abstract:

Compositions for inhibiting the production of exotoxins are disclosed. The compositions include an effective amount of an isoprenoid inhibitory compound to substantially inhibit the production of exotoxins by Gram positive bacteria.

US Patent:

6596290, Jul 22, 2003

Filed:

Oct 2, 2001

Appl. No.:

09/969198

Inventors:

Rae Ellen Syverson - Fond du Lac WI
Richard A. Proctor - Madison WI

Assignee:

Kimberly-Clark Worldwide, Inc. - Neenah WI

International Classification:

A01N 2534

US Classification:

424404, 424402, 424443, 604360

Abstract:

Non-absorbent articles are disclosed. The non-absorbent articles include an effective amount of an isoprenoid inhibitory compound such as a terpene to substantially inhibit the production of exotoxins by Gram positive bacteria.

US Patent:

6821999, Nov 23, 2004

Filed:

Oct 16, 2002

Appl. No.:

10/271474

Inventors:

Rae Ellen Syverson - Fond du Lac WI
Richard A. Proctor - Madison WI

Assignee:

Kimberly-Clark Worldwide, Inc. - Neenah WI

International Classification:

A61K 3138

US Classification:

514438, 514159, 514165, 514441, 514629, 514724, 514730

Abstract:

The present invention relates to inhibiting the production of TSST-1 using absorbent products and non-absorbent products comprising an additive, as well as methods for inhibiting such production. The absorbent and non-absorbent products or articles include an effective amount of an inhibitory compound, such as thiolactomycin or thiomalonate to substantially inhibit the production of TSST-1 or exoprotein by Gram positive bacteria.

US Patent:

6911480, Jun 28, 2005

Filed:

Dec 27, 2002

Appl. No.:

10/330156

Inventors:

Rae Ellen Syverson - Fond du Lac WI, US
Richard A. Proctor - Madison WI, US

Assignee:

Kimberly-Clark Worldwide, Inc. - Neenah WI

International Classification:

A61K031/05

US Classification:

514731, 514967

Abstract:

Methods and compositions for inhibiting the production of exotoxins are disclosed. The compositions include an effective amount of an isoprenoid inhibitory compound to substantially inhibit the production of exotoxins by Gram positive bacteria.

US Patent:

7022333, Apr 4, 2006

Filed:

Oct 2, 2001

Appl. No.:

09/969391

Inventors:

Rae Ellen Syverson - Fond du Lac WI, US
Richard A. Proctor - Madison WI, US

Assignee:

Kimberly-Clark Worldwide, Inc. - Neenah WI

International Classification:

A01N 25/34

US Classification:

424402, 424404, 604360

Abstract:

Non-absorbent articles are disclosed. The non-absorbent articles include an effective amount of an aromatic inhibitory compound to substantially inhibit the production of exotoxins by Gram positive bacteria. The aromatic inhibitory compounds of the present invention have the general formula: wherein Ris selected from the group consisting of H,.

US Patent:

7026354, Apr 11, 2006

Filed:

Oct 2, 2001

Appl. No.:

09/969218

Inventors:

Rae Ellen Syverson - Fond du Lac WI, US
Richard A. Proctor - Madison WI, US

Assignee:

Kimberly-Clark Worldwide, Inc. - Neenah WI

International Classification:

A61K 31/27
A61K 31/24
A62D 3/00
A01N 25/02

US Classification:

514476, 4352521, 424401, 424405

Abstract:

Compositions including an aromatic compound for inhibiting the production of exoproteins by Gram positive bacteria are disclosed. The aromatic inhibitory compounds of the present invention have the general formula: wherein Ris selected from the group consisting of H, —OR, —RC(O)H, —ROH, —RCOOH, —OROH, —ORCOOH, —C(O)NH, and NHand salts thereof; Ris a monovalent saturated or unsaturated aliphatic hydrocarbyl moiety; Ris a divalent saturated or unsaturated aliphatic hydrocarbyl moiety; Ris a trivalent saturated or unsaturated aliphatic hydrocarbyl moiety; Ris a monovalent substituted or unsubstituted saturated or unsaturated aliphatic hydrocarbyl moiety which may or may not be interrupted with hetero atoms; R, R, and Rare independently selected from the group consisting of H, OH, COOH, and —C(O)R; Ris hydrogen or a monovalent saturated or unsaturated aliphatic hydrocarbyl moiety.

US Patent:

7118759, Oct 10, 2006

Filed:

Oct 16, 2002

Appl. No.:

10/271513

Inventors:

Rae Ellen Syverson - Fond du Lac WI, US
Richard A. Proctor - Madison WI, US

Assignee:

Kimberly-Clark Worldwide, Inc. - Neenah WI

International Classification:

A01N 25/34
A61F 6/06
A61F 13/02

US Classification:

424404, 424411, 424430, 424431

Abstract:

Effective amounts of the inhibitory compounds described herein capable of significantly reducing the production of TSST-1 are as follows: (1) compounds of Structure (I): from about 0. 0001 micromoles/gram absorbent product to about 0. 08 micromoles/gram absorbent product, desirably from about 0. 0005 micromoles/gram of absorbent product to about 0. 05 micromoles/gram of absorbent product; and (2) compounds of Structures (II) and (III): from about 0. 05 micromoles/gram of absorbent product to 5 micromoles/gram of absorbent product, desirably from about 0. 1 micromoles/gram of absorbent product to about 1 micromole/gram of absorbent product. Specifically, effective amounts of hexachlorophene include from about 0. 00024 micromoles/gram of absorbent product to about 0. 08 micromoles/gram of absorbent product, desirably from about 0.

US Patent:

7258867, Aug 21, 2007

Filed:

Mar 18, 2004

Appl. No.:

10/803345

Inventors:

Rae Ellen Syverson - Fond du Lac WI, US
Richard A. Proctor - Madison WI, US

Assignee:

Kimberly-Clark Worldwide, Inc. - Neenah WI

International Classification:

A61F 9/00
A61F 13/15
A01N 25/34

US Classification:

424400, 424402, 424404, 604360

Abstract:

Non-absorbent articles are disclosed. The non-absorbent articles include an effective amount of an aromatic inhibitory compound to substantially inhibit the production of exotoxins by Gram positive bacteria. The aromatic inhibitory compounds of the present invention have the general formula:.