Richard L Reitz

US Patent:

20210041462, Feb 11, 2021

Filed:

Apr 24, 2020

Appl. No.:

16/857628

Inventors:

- Wilmington DE, US
Shijun Sheng - Las Flores CA, US
Nigel Clarke - Vista CA, US
Richard E. Reitz - Las Vegas NV, US

International Classification:

G01N 33/74
G01N 33/68

Abstract:

Methods are provided for determining the amount of an IGF-I and/or IGF-II protein in a sample using high resolution/high accuracy mass spectrometry. The methods generally comprise enriching an IGF-I and/or IGF-II protein in a sample, ionizing an IGF-I and/or IGF-II protein from the sample to generate IGF-I and/or IGF-II protein ions, and determining the amount of IGF-I and/or IGF-II protein ions with high resolution/high accuracy mass spectrometry.

US Patent:

20200241018, Jul 30, 2020

Filed:

Sep 30, 2019

Appl. No.:

16/588709

Inventors:

- Wilmington DE, US
Nigel J. Clarke - Vista CA, US
Richard E Reitz - Las Vegas NV, US

International Classification:

G01N 33/82
G01N 30/88
G01N 30/72
H01J 49/00

Abstract:

The invention relates to the detection of vitamin D metabolites. In a particular aspect, the invention relates to methods for detecting derivatized vitamin D metabolites by mass spectrometry.

US Patent:

20190317109, Oct 17, 2019

Filed:

Jun 3, 2019

Appl. No.:

16/429941

Inventors:

- Wilmington DE, US
Nigel J. Clarke - Vista CA, US
Richard E Reitz - Las Vegas NV, US

International Classification:

G01N 33/68
G01N 33/78

Abstract:

Provided are methods for determining the amount of thyroglobulin in a sample using various purification steps followed by mass spectrometry. The methods generally involve purifying thyroglobulin in a test sample, digesting thyroglobulin to form peptide T129, purifying peptide T129, ionizing peptide T129, detecting the amount of peptide T129 ion generated, and relating the amount of peptide T129 ion to the amount of thyroglobulin originally present in the sample.

US Patent:

20190145984, May 16, 2019

Filed:

Jan 28, 2019

Appl. No.:

16/259696

Inventors:

- Wilmington DE, US
Nigel J. Clarke - Vista CA, US
Richard E. Reitz - Las Vegas NV, US

International Classification:

G01N 33/68
C12Q 1/37
G01N 33/78

Abstract:

Provided are methods for determining the amount of thyroglobulin in a sample using various purification steps followed by mass spectrometry. The methods generally involve purifying thyroglobulin in a test sample, digesting thyroglobulin to form peptide T129, purifying peptide T129, ionizing peptide T129, detecting the amount of peptide T129 ion generated, and relating the amount of peptide T129 ion to the amount of thyroglobulin originally present in the sample.

US Patent:

20180128841, May 10, 2018

Filed:

May 23, 2017

Appl. No.:

15/602764

Inventors:

- Wilmington DE, US
Shijun Sheng - Las Flores CA, US
Nigel Clarke - Vista CA, US
Richard E. Reitz - Las Vegas NV, US

International Classification:

G01N 33/74
G01N 33/68

Abstract:

Methods are provided for determining the amount of an IGF-I and/or IGF-II protein in a sample using high resolution/high accuracy mass spectrometry. The methods generally comprise enriching an IGF-I and/or IGF-II protein in a sample, ionizing an IGF-I and/or IGF-II protein from the sample to generate IGF-I and/or IGF-II protein ions, and determining the amount of IGF-I and/or IGF-II protein ions with high resolution/high accuracy mass spectrometry.

US Patent:

20170248620, Aug 31, 2017

Filed:

Apr 17, 2017

Appl. No.:

15/489551

Inventors:

- Wilmington DE, US
Nigel J. Clarke - Vista CA, US
Richard E Reitz - Las Vegas NV, US

International Classification:

G01N 33/82
G01N 30/88
G01N 30/72

Abstract:

The invention relates to the detection of vitamin D metabolites. In a particular aspect, the invention relates to methods for detecting derivatized vitamin D metabolites by mass spectrometry.