Deborah A. Eppstein - Palo Alto CA 94303 Philip L. Felgner - Palo Alto CA 94303 Thomas R. Gadek - Palo Alto CA 94303 Gordon H. Jones - Palo Alto CA 94303 Richard B. Roman - Palo Alto CA 94303
International Classification:
A61K 9127
US Classification:
424450, 935 54
Abstract:
This invention relates to compounds of the formula or an optical isomer thereof wherein R and R are the same or different and are an alkyl or alkenyl group of 6 to 24 carbon atoms; R , R and R are the same or different and are alkyl of 1 to 8 carbon atoms, aryl, aralkyl of 7 to 11 carbon atoms, or when two or three of R , R , and R are taken together to form quinuclidino, piperidino, pyrrolidino, or morpholino; n is 1 to 8; and X is a pharmaceutically acceptable anion.
N-.Omega.,(.Omega.-1)-Dialkyloxy)- And N-(.Omega.,(.Omega.-1)-Dialkenyloxy)Alk-1-Yl-N,N,N-Tetrasubstituted Ammonium Lipids And Uses Therefor
Deborah A. Eppstein - Menlo Park CA Philip L. Felgner - Los Altos CA Thomas R. Gadek - Oakland CA Gordon H. Jones - Cupertino CA Richard B. Roman - Fairhope AL
Assignee:
Syntex (U.S.A.) Inc. - Palo Alto CA
International Classification:
A61F 200
US Classification:
424427
Abstract:
This invention relates to compounds of the formula ##STR1## or an optical isomer thereof wherein R. sup. 1 and R. sup. 2 are the same or different and are an alkyl or alkenyl group of 6 to 24 carbon atoms; R. sup. 3, R. sup. 4 and R. sup. 5 are the same or different and are alkyl of 1 to 8 carbon atoms, aryl, aralkyl of 7 to 11 carbon atoms, or when two or three of R. sup. 3, R. sup. 4, and R. sup. 5 are taken together to form quinuclidino, piperidino, pyrrolidino, or morpholino; n is 1 to 8; and X is a pharmaceutically acceptable anion.
N[.Omega.,(.Omega.-1)-Dialkyloxy]- And N-[.Omega.,(.Omega.-1)-Dialkenyloxy]-Alk-1-Yl-N,N,N-Tetrasubstituted Ammonium Lipids And Uses Therefor
Deborah A. Eppstein - Menlo Park CA Philip L. Felgner - Los Altos CA Thomas R. Gadek - Oakland CA Gordon H. Jones - Cupertino CA Richard B. Roman - Fairhope AL
Assignee:
Syntex (U.S.A.) Inc. - Palo Alto CA
International Classification:
C12N 500
US Classification:
4352402
Abstract:
This invention relates to compounds of the formula ##STR1## or an optical isomer thereof wherein R. sup. 1 and R. sup. 2 are the same or different and are an alkyl or alkenyl group of 6 to 24 carbon atoms; R. sup. 3, R. sup. 4 and R. sup. 5 are the same or different and are alkyl of 1 to 8 carbon atoms, aryl, aralkyl of 7 to 11 carbon atoms, or when two or three of R. sup. 3, R. sup. 4, and R. sup. 5 are taken together to form quinuclidino, piperidino, pyrrolidino, or morpholino; n is 1 to 8; and X is a pharmaceutically acceptable anion.
N-(.Omega.,(.Omega.-1)-Dialkyloxy)- And N-(.Omega.,(.Omega.-1)-Dialkenyloxy)-Alk-1-Yl-N,N,N-Tetrasubstituted Ammonium Lipids And Uses Therefor
Deborah A. Eppstein - Menlo Park CA Philip L. Felgner - Los Altos CA Thomas R. Gadek - Oakland CA Gordon H. Jones - Cupertino CA Richard B. Roman - Fairhope AL
Assignee:
Syntex (U.S.A.) Inc. - Palo Alto CA
International Classification:
A61K 950 A61K 4502
US Classification:
4352402
Abstract:
This invention relates to compounds of the formula ##STR1## or an optical isomer thereof wherein R. sup. 1 and R. sup. 2 are the same or different and are an alkyl or alkenyl group of 6 to 24 carbon atoms; R. sup. 3, R. sup. 4 and R. sup. 5 are the same or different and are alkyl of 1 to 8 carbon atoms, aryl, aralkyl of 7 to 11 carbon atoms, or when two or three of R. sup. 3, R. sup. 4, and R. sup. 5 are taken together to form quinuclidino, piperidino, pyrrolidino, or morpholino; n is 1 to 8; and X is a pharmaceutically acceptable anion.
N-[.Omega.,(.Omega.-1)-Dialkyloxy]- And N-[.Omega.,(.Omega.-1)-Dialkenyloxy]-Alk-1-Yl-N,N,N,-Tetrasubstituted Ammonium Lipids And Uses Therefor
Deborah A. Eppstein - Menlo Park CA Philip L. Felgner - Los Altos CA Thomas R. Gadek - Oakland CA Gordon H. Jones - Cupertino CA Richard B. Roman - Fairhope AL
Assignee:
Syntex (U.S.A.) Inc. - Palo Alto CA
International Classification:
A61K 3722 A61K 970 C12N 120 B01J 1302
US Classification:
424450
Abstract:
This invention relates to compounds of the formula or an optical isomer thereof wherein R. sup. 1 and R. sup. 2 are the same or different and are an alkyl or alkenyl group of 6 to 24 carbon atoms; R. sup. 3, R. sup. 4 and R. sup. 5 are the same or different and are alkyl of 1 to 8 carbon atoms, aryl, aralkyl of 7 to 11 carbon atoms, or when two or three of R. sup. 3, R. sup. 4, and R. sup. 5 are taken together to form quinuclidino, piperidino, pyrrolidino, or morpholino; n is 1 to 8; and X is a pharmaceutically acceptable anion.
N-[.Omega., (.Omega.-1)-Dialkyloxy]- And N-[.Omega., (.Omega.-1)-Dialkenyloxy]-Alk-1-Yl-N, N, N-Tetrasubstituted Ammonium Lipids And Uses Therefor
Deborah A. Eppstein - Menlo Park CA Philip L. Felgner - Los Altos CA Thomas R. Gadek - Oakland CA Gordon H. Jones - Cupertino CA Richard B. Roman - Fairhope AL
Assignee:
Syntex (U.S.A.) Inc. - Palo Alto CA
International Classification:
A61F 202 A61K 970 A61K 9127 B01J 1302
US Classification:
424450
Abstract:
This invention relates to compounds of the formula ##STR1## or an optical isomer thereof wherein R. sup. 1 and R. sup. 2 are the same or different and are an alkyl or alkenyl group of 6 to 24 carbon atoms; R. sup. 3, R. sup. 4, R. sup. 5 are the same or different and are alkyl of 1 to 8 carbon atoms, aryl, aralkyl of 7 to 11 carbon atoms, or when two or three of R. sup. 3, R. sup. 4, and R. sup. 5 are taken together to form quinuclidino, piperidino, pyrrolidino, or morpholino; n is 1 to 8; and X is a pharmaceutically acceptable anion.
N-[1, (1-1)-Dialkyloxy]-And N-[1, (1-1)-Dialkenyloxy]-Alk-1-Yl-N,N,N-Tetrasubstituted Ammonium Lipids And Uses Therefor
Deborah A. Eppstein - Menlo Park CA Philip L. Felgner - Los Altos CA Thomas R. Gadek - Oakland CA Gordon H. Jones - Cupertino CA Richard B. Roman - Fairhope AL
Assignee:
Syntex (U.S.A.) Inc. - Palo Alto CA
International Classification:
A61K 9127 A61K 970 A61F 202 B01J 1302
US Classification:
424450
Abstract:
This invention relates to compounds of the formula ##STR1## or an optical isomer thereof wherein R. sup. 1 and R. sup. 2 are the same or different and are an alkyl or alkenyl group of 6 to 24 carbon atoms; R. sup. 3, R. sup. 4 and R. sup. 5 are the same or different and are alkyl of 1 to 8 carbon atoms, aryl, aralkyl of 7 to 11 carbon atoms, or when two or three of R. sup. 3, R. sup. 4, and R. sup. 5 are taken together to form quinuclidino, piperidino, pyrrolidino, or morpholino, n is 1 to 8; and X is a pharmaceutically acceptable anion.
N-(1,(1-1)-Dialkyloxy)-And N-(1,(1-1)-Dialkenyloxy Alk-1-Yl-N-N,N-Tetrasubstituted Ammonium Lipids And Uses Therefor
Deborah A. Eppstein - Menlo Park CA Philip L. Felgner - Los Altos CA Thomas R. Gadek - Oakland CA Gordon H. Jones - Cupertino CA Richard B. Roman - Fairhope AL
Assignee:
Syntex (U.S.A.) Inc. - Palo Alto CA
International Classification:
C07C21306 A61F 202 A61K 9127 A61K 970
US Classification:
564293
Abstract:
This invention relates to compounds of the formula ##STR1## or an optical isomer thereof wherein R. sup. 1 and R. sup. 2 are the same or different and are an alkyl or alkenyl group of 6 to 24 carbon atoms; R. sup. 3, R. sup. 4 and R. sup. 5 are the same or different and are alkyl of 1 to 8 carbon atoms, aryl, aralkyl of 7 to 11 carbon atoms, or when two or three of R. sup. 3, R. sup. 4, and R. sup. 5 are taken together to form quinuclidino, piperidino, pyrrolidino, or morpholino; n is 1 to 8; and X is a pharmaceutically acceptable anion.
Fry's Electronics Inc Las Vegas, NV 2003 to 2004Sato America Inc Sunnyvale, CA 1999 to 2001 Quality Control Specialist/ ServiceRoman Tires Inc Santa Clara, CA 1995 to 1999
City of Hope Medical Center Duarte, CA Feb 2014 to Jun 2014 Physician trainerCooley Dickinson Hospital West Hampton, VA Jan 2014 to Jan 2014 Physician trainerMethodist medical center of Houston Houston, TX Nov 2013 to Dec 2013 Consultant trainerLSI international Washington, DC Jul 2013 to Nov 2013 E -Clinical Works TrainerThe Methodist Medical Center Of Houston, BaytownTx Houston, TX Jun 2013 to Nov 2013 Activation ConsultantSouth Nassau Communities Hospital
Apr 2013 to May 2013 Team Lead Support of Allscripts VBaylor University Medical Center Dallas, TX Dec 2010 to Mar 2013 Clinical Systems LeadBaylor University Medical Center
Jul 2011 to Oct 2011 Clinical Systems Lead TrainerCornell-Weill Medical & Columbia University Medical Centers New York, NY May 2009 to Dec 2010 Clinical Systems Lead TrainerMaimonides Medical Center Brooklyn, NY Oct 2008 to Jun 2009 Clinical Systems TrainerCPOE Ann Arbor, MI Mar 2008 to Jul 2008 Implementation Activation Lead ConsultantNew York Presbyterian Cornell-Weill and Columbia Medical Centers New York, NY Jan 2008 to Feb 2008 EMR TrainerUniversity of Michigan Medical Center Ann Arbor, MI Aug 2006 to Sep 2007 Implementation of Eclipsys Sunrise Clinical ManagerQueens Long Island Medical Group, P.C Garden City, NY Jan 2003 to Aug 2006 Help Desk Manager/Telecommunications Support ManagerUrban League of Long Island, Inc Central Islip, NY Jan 2000 to Jun 2003 IT Team Leader / Project LeaderUS Army Nation wide Nov 1990 to Jun 2000 Career Counselor / Training NCOUnited States Army
Nov 1976 to Nov 1990 Practical Nurse /EMT Paramedic
Education:
University of Michigan Medical Center Ann Arbor, MI Aug 2006 to Sep 2007 ClinicalNew York University Medical Center New York, NY Mar 2007
Medicine Doctors
Dr. Richard S Roman, Pleasanton CA - DDS (Doctor of Dental Surgery)
Acute Pancreatitis Benign Polyps of the Colon Diverticulitis Esophagitis Gastritis and Duodenitis
Languages:
English Spanish
Description:
Dr. Roman graduated from the Tufts University School of Medicine in 1990. He works in Lone Tree, CO and 2 other locations and specializes in Gastroenterology. Dr. Roman is affiliated with Craig Hospital, Littleton Adventist Hospital, Parker Adventist Hospital, Porter Adventist Hospital, Sky Ridge Medical Center and Swedish Medical Center.