Richard L Saunders

US Patent:

6352718, Mar 5, 2002

Filed:

Sep 25, 2000

Appl. No.:

09/668883

Inventors:

Joseph K. Yoon - Palisade Park NJ
Richard W. Saunders - Palisades NY
Mahdi Fawzi - Morristown NJ

Assignee:

American Cyanamid Company - Madison NJ

International Classification:

A61K 964

US Classification:

424456, 424484, 424486, 514220, 514561, 514562, 514563, 514564

Abstract:

This invention provides novel formulations for N-[4-(5H-pyrrolo[2,1-c][1,4]benzodiazepin-10(11H)ylcarbonyl)-3-chlorophenyl]-5-fluoro-2-methyl-benzamide, or a pharmaceutically acceptable salt thereof, and processes for making them, the formulations comprising from about 1% to about 20% of active ingredient, from about 1% to about 18% of a surfactant component, from about 50% to about 80% of a component of one or more polyethylene glycols, from about 1% to about 20% of a component of one or more sucrose fatty acid esters and/or polyvinylpyrrolidone and, optionally, one or more pharmaceutically acceptable preservatives or antioxidants.

US Patent:

6437006, Aug 20, 2002

Filed:

Sep 25, 2000

Appl. No.:

09/668970

Inventors:

Joseph K. Yoon - Palisade Park NJ
Richard W. Saunders - Palisades NY
Mahdi Fawzi - Morristown NJ

Assignee:

American Cyanamid Company - Madison WI

International Classification:

A61K 4732

US Classification:

5147725, 514966, 424464, 424474, 424480, 424485

Abstract:

This invention provides carrier systems useful in preparing pharmaceutical formulations, the systems comprising, by weight percentage, from about 1% to about 20%, preferably from about 5% to about 12%, of a surfactant component; from about 55% to about 93%, preferably from about 60% to about 85%, of a component of one or more polyethylene glycols (PEG); and from about 1% to about 25%, preferably from about 5% to about 15%, of one or more sucrose fatty acid esters or polyvinylpyrrolidone (PVP) with a K value between about 15 and about 90, preferably with a K value of from about 16 to about 18, most preferably about 17, as defined in USP/NF, or a combination of one or more sucrose fatty acid esters or PVP, and, optionally, one or more pharmaceutically acceptable preservatives or antioxidants, such as BHA, BHT, ascorbyl palmitate or benzyl alcohol.

US Patent:

6831079, Dec 14, 2004

Filed:

Sep 25, 2000

Appl. No.:

09/669204

Inventors:

Joseph K. Yoon - Palisade Park NJ
Richard W Saunders - Palisades NY
Mahdi Fawzi - Morristown NJ

Assignee:

American Cyanamid Company - Madison NJ

International Classification:

A61K 3155

US Classification:

514220, 514937, 424452, 424455

Abstract:

This invention provides novel formulations for vasopressin agonist compounds, or a pharmaceutically acceptable salt thereof, having the general structure: and processes for making them, the formulations comprising from about 1% to about 20% of active ingredient, from about 1% to about 18% of a surfactant component, from about 50% to about 80% of a component of one or more polyethylene glycols, from about 1% to about 20% of a component of one or more sucrose fatty acid esters and/or polyvinylpyrrolidone and, optionally, one or more preservatives or antioxidants.