Richard C Stevens

US Patent:

6449647, Sep 10, 2002

Filed:

Sep 21, 1999

Appl. No.:

09/400635

Inventors:

Steven Colby - Billerica MA
John J. Krawczyk - Arlington MA
Rai Krishnan Nair - Acton MA
Katherine Royce - Manchester NH
Kenneth P. Siegel - Nashua NH
Richard C. Stevens - Littleton MA
Scott Wasson - Shrewsbury MA

Assignee:

Cisco Systems, Inc. - San Jose CA

International Classification:

G06F 15173

US Classification:

709226, 709220, 709240

Abstract:

A content-aware flow switch intercepts a client content request in an IP network, and transparently directs the content request to a best-fit server. The best-fit server is chosen based on the type of content requested, the quality of service requirements implied by the content request, the degree of load on available servers, network congestion information, and the proximity of the client to available servers. The flow switch detects client-server flows based on the arrival of TCP SYNs and/or HTTP GETs from the client. The flow switch implicitly deduces the quality of service requirements of a flow based on the content of the flow. The flow switch also provides the functionality of multiple physical web servers on a single web server in a way that is transparent to the client, through the use of virtual web hosts and flow pipes.

US Patent:

6862624, Mar 1, 2005

Filed:

Jul 17, 2002

Appl. No.:

10/197339

Inventors:

Steven Colby - Billerica MA, US
John J. Krawczyk - Arlington MA, US
Raj Krishnan Nair - Acton MA, US
Katherine Royce - Manchester NH, US
Kenneth P. Siegel - Nashua NH, US
Richard C. Stevens - Littleton MA, US
Scott Wasson - Shrewsbury MA, US

Assignee:

Cisco Technology, Inc. - San Jose CA

International Classification:

G06F015/173

US Classification:

709226, 709240, 709220

Abstract:

A content-aware flow switch intercepts a client content request in an IP network, and transparently directs the content request to a best-fit server. The best-fit server is chosen based on the type of content requested, the quality of service requirements implied by the content request, the degree of load on available servers, network congestion information, and the proximity of the client to available servers. The flow switch detects client-server flows based on the arrival of TCP SYNs and/or HTTP GETs from the client. The flow switch implicitly deduces the quality of service requirements of a flow based on the content of the flow. The flow switch also provides the functionality of multiple physical web servers on a single web server in a way that is transparent to the client, through the use of virtual web hosts and flow pipes.

US Patent:

7257634, Aug 14, 2007

Filed:

Feb 11, 2005

Appl. No.:

11/056031

Inventors:

Steven Colby - Billerica MA, US
John J. Krawczyk - Arlington MA, US
Raj Krishnan Nair - Acton MA, US
Katherine Royce - Manchester NH, US
Kenneth P. Siegel - Nashua NH, US
Richard C. Stevens - Littleton MA, US
Scott Wasson - Shrewsbury MA, US

Assignee:

Cisco Technology, Inc. - San Jose CA

International Classification:

G06F 15/173
G06F 15/177

US Classification:

709226, 709240

Abstract:

A content-aware flow switch intercepts a client content request in an IP network, and transparently directs the content request to a best-fit server. The best-fit server is chosen based on the type of content requested, the quality of service requirements implied by the content request, the degree of load on available servers, network congestion information, and the proximity of the client to available servers. The flow switch detects client-server flows based on the arrival of TCP SYNs and/or HTTP GETs from the client. The flow switch implicitly deduces the quality of service requirements of a flow based on the content of the flow. The flow switch also provides the functionality of multiple physical web servers on a single web server in a way that is transparent to the client, through the use of virtual web hosts and flow pipes.

US Patent:

53170857, May 31, 1994

Filed:

Jul 7, 1992

Appl. No.:

7/909644

Inventors:

Richard L. Stevens - Sudbury MA
John H. Weis - Salt Lake City UT
Christopher F. Nicodemus - Franconia NH

Assignee:

Brigham And Women's Hospital - Boston MA

International Classification:

C07K 708

US Classification:

530326

Abstract:

This invention relates to the identification, characterization, and sequencing of genetic sequences of human secretory granule proteoglycan peptide core protein, recombinant DNA clones directed against this sequence and against the sequence of the antisense RNA, and antibodies which recognize the native human secretory granule proteoglycan.

US Patent:

41346785, Jan 16, 1979

Filed:

Mar 16, 1977

Appl. No.:

5/778045

Inventors:

Leslie J. Brown - Chestnut Hill MA
Bruno DeGironimo - Billerica MA
Charles F. Mountain - Cambridge MA
Richard B. Stevens - Somerville MA
Fernando M. Vasconcelos - Lowell MA

Assignee:

Instrumentation Laboratory Inc. - Lexington MA

International Classification:

G01N 3316

US Classification:

356 39

Abstract:

Method and apparatus for the simultaneous automatic analysis and sequential displaying in digital form of a plurality of parameters of whole or hemolyzed blood samples, such as total hemoglobin, percent oxyhemoglobin, percent carboxyhemoglobin, percent methemoglobin (in each case percent meaning percentage of total hemoglobin) and oxygen content. The apparatus is an electro-optical instrument including a servo-controlled spectral line source, such as a hollow cathode lamp, a laser etc. , a ratiometric logarithmic amplifier of minimized dynamic range, a fluid-flow system of improved design that combine to measure the absorbances of blood samples at a plurality of wavelengths defined and generated by the spectral line source, to calculate the above parameters based on the absorbances by the use of a micro-computer and associated circuitry absorbances, to display automatically and digitally one of the parameters, and then to display digitally seriatim the remaining parameters responsive to operator intervention.

US Patent:

51716747, Dec 15, 1992

Filed:

Jan 18, 1991

Appl. No.:

7/635544

Inventors:

Richard L. Stevens - Sudbury MA
John H. Weis - Salt Lake City UT
Christopher F. Nicodemus - Franconia NH

Assignee:

Brigham and Women's Hospital - Boston MA

International Classification:

C12P 2102
C12N 121
C12N 510
C07H 2104

US Classification:

435 691

Abstract:

This invention relates to the identification, characterization, and sequencing of genetic sequences of human secretory granule proteoglycan peptide core protein, recombinant DNA clones directed against this sequence and against the sequence of the antisense RNA, and antobodies which recognize the native human secretory granule proteoglycan.

US Patent:

53407393, Aug 23, 1994

Filed:

Jul 2, 1992

Appl. No.:

7/906871

Inventors:

Richard L. Stevens - Sudbury MA
Shalom Avraham - Brighton MA

Assignee:

Brigham & Women's Hospital - Boston MA

International Classification:

C12N 510
C12N 516
C12N 100
C12N 1563

US Classification:

4352401

Abstract:

A negative transcription regulatory element (a constitutive suppressor) between residues -250 and -190 of the 5' flanking region of the mouse serglycin gene, a positive (hematopoietic cell enhancer) regulatory element located between residues -118 and -81, an equivalent of the TATA- box and a novel eukaryotic promoter that utilizes such equivalent, vectors containing such elements and hosts transformed therewith, are described. These regulatory elements, vectors and hosts are useful in gene transcription of heterologous genes in eukaryotic cells, and especially in hematopoietic cells. In addition, transcriptional factors that bind to these elements are described.

US Patent:

59554312, Sep 21, 1999

Filed:

Jan 30, 1998

Appl. No.:

9/016366

Inventors:

Richard L. Stevens - Sudbury MA
Chifu Huang - Boston MA

Assignee:

Brigham and Women's Hospital, Inc. - Boston MA

International Classification:

A61K 3804
A61K 3805
A61K 3808

US Classification:

514 17

Abstract:

Compositions and methods for inhibiting a complex containing a mast cell protease are provided. The compositions are useful for treating inflammatory disorders, such as asthma, that are mediated by release of a tryptase-6 protein. Methods for identifying additional specific inhibitors of a complex containing tryptase-6 protein and a serglycin glycosaminoglycan also are provided.