Richard B Summers

US Patent:

20030013662, Jan 16, 2003

Filed:

Dec 11, 2000

Appl. No.:

09/735056

Inventors:

Leonard Katz - Wheeling IL, US
Diane Stassi - Highland Park IL, US
Richard Summers - Nashotah WI, US
Xiaoan Ruan - Lake Bluff IL, US
Stephan Kakavas - Buffalo Grove IL, US

International Classification:

A61K031/7048
C07H017/08

US Classification:

514/028000, 536/007400, 536/007100

Abstract:

The invention provides novel erythromycin derivatives in which methyl groups on the macrolactone ring have been substituted with —H, -Et, and/or —OH. The invention also provides reagents such as isolated polynucleotides, vectors comprising the polynucleotides and host cells transformed with the vectors for making the novel compounds. Methods for making the compounds utilizing genetic engineering techniques are also disclosed.

US Patent:

60602341, May 9, 2000

Filed:

May 16, 1997

Appl. No.:

8/858003

Inventors:

Leonard Katz - Wheeling IL
Diane L. Stassi - Highland Park IL
Richard G. Summers - Nashotah WI
Xiaoan Ruan - Lake Bluff IL
Stephan J. Kakavas - Buffalo Grove IL

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

C12Q 100
C12Q 118
C07H 1708

US Classification:

435 4

Abstract:

The invention provides novel erythromycin derivatives in which methyl groups on the macrolactone ring have been substituted with --H, --Et, and/or --OH. The invention also provides reagents such as isolated polynucleotides, vectors comprising the polynucleotides and host cells transformed with the vectors for making the novel compounds. Methods for making the compounds utilizing genetic engineering techniques are also disclosed.

US Patent:

62008137, Mar 13, 2001

Filed:

Dec 23, 1997

Appl. No.:

8/997467

Inventors:

Leonard Katz - Wheeling IL
Diane L. Stassi - Highland Park IL
Richard G. Summers - Nashotah WI
Xiaoan Ruan - Lake Bluff IL
Stephan J. Kakavas - Buffalo Grove IL

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

C12N 1500
C12N 1554
C12N 1562
C12N 1576

US Classification:

435477

Abstract:

The invention provides novel erythromycin derivatives in which methyl groups on the macrolactone ring have been substituted with --H, -Et, and/or --OH. The invention also provides reagents such as isolated polynucleotides, vectors comprising the polynucleotides and host cells transformed with the vectors for making the novel compounds. Methods for making the compounds utilizing genetic engineering techniques are also disclosed.

US Patent:

60635614, May 16, 2000

Filed:

May 13, 1998

Appl. No.:

9/078166

Inventors:

Leonard Katz - Wheeling IL
Diane L. Stassi - Highland Park IL
Richard G. Summers - Appleton WI
Xiaoan Ruan - Lake Bluff IL
Stephan J. Kakavas - Buffalo Grove IL

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

C12Q 100
C12Q 148
C12Q 102
C07H 1708

US Classification:

435 4

Abstract:

The invention provides novel erythromycin derivatives in which methyl groups on the macrolactone ring have been substituted with --H, -Et, and/or --OH and the ethyl side-chain has been substituted with hydroxymethyl or dihydroxycyclohexylmethyl side-chains. The invention also provides reagents such as isolated polynucleotides, vectors comprising the polynucleotides and host cells transformed with the vectors for making the novel compounds. Methods for making the compounds utilizing genetic engineering techniques are also disclosed.