Richard Ray Watson

US Patent:

7832920, Nov 16, 2010

Filed:

Oct 25, 2007

Appl. No.:

11/924589

Inventors:

Anthony B. Wood - Dallas TX, US
Gregory J. Archambeau - Puyallap WA, US
Richard L. Watson - McPherson KS, US

Assignee:

Revalesio Corporation - Tacoma WA

International Classification:

B01F 7/12

US Classification:

3661703, 3661711, 3661721, 366305

Abstract:

A mixing device for mixing a first and second material together to create an output mixture. The device includes a first chamber containing the first material coupled to a mixing chamber defined between a rotor and a stator. The rotor is disposed inside the stator and rotates therein about an axis of rotation. The first chamber houses an internal pump configured to pump the first material from the first chamber into the mixing chamber. The pump may be configured to impart a circumferential velocity into the first material before it enters the mixing chamber. At least one of the rotor and stator have a plurality of through-holes through which the second material is provided to the mixing chamber. Optionally, a second chamber is coupled to the mixing chamber. The second chamber may house an internal pump configured to pump the output material from the mixing chamber into the second chamber.

US Patent:

7919534, Apr 5, 2011

Filed:

Oct 25, 2007

Appl. No.:

11/924595

Inventors:

Anthony B. Wood - Dallas TX, US
Gregory J. Archambeau - Puyallap WA, US
Richard L. Watson - McPherson KS, US

Assignee:

Revalesio Corporation - Tacoma WA

International Classification:

B01F 3/04

US Classification:

516 10, 3661524

Abstract:

Particular aspects provide compositions comprising an electrokinetically altered oxygenated aqueous fluid, wherein the oxygen in the fluid is present in an amount of at least 25 ppm. In certain aspects, the electrokinetically altered oxygenated aqueous fluid comprises electrokinetically modified or charged oxygen species present in an amount of at least 0. 5 ppm. In certain aspects the electrokinetically altered oxygenated aqueous fluid comprises solvated electrons stabilized by molecular oxygen, and wherein the solvated electrons present in an amount of at least 0. 01 ppm. In certain aspects, the fluid facilitates oxidation of pyrogallol to purpurogallin in the presence of horseradish peroxidase enzyme (HRP) in an amount above that afforded by a control pressure pot generated or fine-bubble generated aqueous fluid having an equivalent dissolved oxygen level, and wherein there is no hydrogen peroxide, or less than 0. 1 ppm of hydrogen peroxide present in the electrokinetic oxygen-enriched aqueous fluid.

US Patent:

8410182, Apr 2, 2013

Filed:

Apr 30, 2009

Appl. No.:

12/433741

Inventors:

Anthony B. Wood - Dallas TX, US
Gregory J. Archambeau - Puyallap WA, US
Richard L. Watson - McPherson KS, US

Assignee:

Revalesio Corporation - Tacoma WA

International Classification:

B01F 3/04
C02F 1/46

US Classification:

516 10, 204221, 204468, 977837

Abstract:

Provided are electrokinetically-altered fluids (e. g. , gas-enriched (e. g. , oxygen-enriched) electrokinetic fluids) comprising an ionic aqueous solution of charge-stabilized oxygen-containing nanostructures in an amount sufficient to provide, upon contact with a cell, modulation of at least one of cellular membrane potential and cellular membrane conductivity. Further provided are the methods of making the electrokinetically-altered ionic aqueous fluid compositions. Particular aspects provide for regulating or modulating intracellular signal transduction associated by modulation of at least one of cellular membranes, membrane potential, membrane proteins such as membrane receptors, including but not limited to G-Protein Coupled Receptors (GPCR), and intercellular junctions (e. g. , tight junctions, gap junctions, zona adherins and desmasomes). Other embodiments include particular methods of producing the electrokinetically-altered fluids.

US Patent:

8445546, May 21, 2013

Filed:

May 4, 2010

Appl. No.:

12/773825

Inventors:

Anthony B. Wood - Dallas TX, US
Richard L. Watson - McPherson KS, US
Gregory J. Archambeau - Puyallup WA, US

Assignee:

Revalesio Corporation - Tacoma WA

International Classification:

B01F 3/04

US Classification:

516 10

Abstract:

Provided are electrokinetically-altered fluids (e. g. , gas-enriched (e. g. , oxygen-enriched) electrokinetic fluids) comprising an ionic aqueous solution of charge-stabilized gas-containing nanostructures in an amount sufficient to provide, upon contact with a cell, modulation of at least one of cellular membrane potential and cellular membrane conductivity. Further provided are the methods of making the electrokinetically-altered ionic aqueous fluid compositions. Particular aspects provide for regulating or modulating intracellular signal transduction associated by modulation of at least one of cellular membranes, membrane potential, membrane proteins such as membrane receptors, including but not limited to G-Protein Coupled Receptors (GPCR), and intercellular junctions (e. g. , tight junctions, gap junctions, zona adherins and desmasomes). Other embodiments include particular methods of producing the electrokinetically-altered fluids.

US Patent:

8449172, May 28, 2013

Filed:

Nov 12, 2010

Appl. No.:

12/945703

Inventors:

Anthony B. Wood - Dallas TX, US
Gregory J. Archambeau - Puyallup WA, US
Richard L. Watson - McPherson KS, US

Assignee:

Revalesio Corporation - Tacoma WA

International Classification:

B01F 7/12

US Classification:

3661703, 3661711, 3661721, 366305

Abstract:

A mixing device for mixing a first and second material together to create an output mixture. The device includes a first chamber containing the first material coupled to a mixing chamber defined between a rotor and a stator. The rotor is disposed inside the stator and rotates therein about an axis of rotation. The first chamber houses an internal pump configured to pump the first material from the first chamber into the mixing chamber. The pump may be configured to impart a circumferential velocity into the first material before it enters the mixing chamber. At least one of the rotor and stator have a plurality of through-holes through which the second material is provided to the mixing chamber. Optionally, a second chamber is coupled to the mixing chamber. The second chamber may house an internal pump configured to pump the output material from the mixing chamber into the second chamber.

US Patent:

8470893, Jun 25, 2013

Filed:

Jan 28, 2011

Appl. No.:

13/016659

Inventors:

Anthony B. Wood - Dallas TX, US
Gregory J. Archambeau - Puyallup WA, US
Richard L. Watson - McPherson KS, US

Assignee:

Revalesio Corporation - Tacoma WA

International Classification:

B01F 3/04

US Classification:

516 10

Abstract:

Particular aspects provide compositions comprising an electrokinetically altered oxygenated aqueous fluid, wherein the oxygen in the fluid is present in an amount of at least 25 ppm. In certain aspects, the electrokinetically altered oxygenated aqueous fluid comprises electrokinetically modified or charged oxygen species present in an amount of at least 0. 5 ppm. In certain aspects the electrokinetically altered oxygenated aqueous fluid comprises solvated electrons stabilized by molecular oxygen, and wherein the solvated electrons present in an amount of at least 0. 01 ppm. In certain aspects, the fluid facilitates oxidation of pyrogallol to purpurogallin in the presence of horseradish peroxidase enzyme (HRP) in an amount above that afforded by a control pressure pot generated or fine-bubble generated aqueous fluid having an equivalent dissolved oxygen level, and wherein there is no hydrogen peroxide, or less than 0. 1 ppm of hydrogen peroxide present in the electrokinetic oxygen-enriched aqueous fluid.

US Patent:

8555914, Oct 15, 2013

Filed:

Jan 2, 2013

Appl. No.:

13/732999

Inventors:

Maurice Slot - Nichols Hills OK, US
Richard R. Watson - Missouri City TX, US

Assignee:

National Coupling Company, Inc. - Stafford TX

International Classification:

F16K 31/12

US Classification:

137486, 1374875, 137487, 137 10, 137 12, 1663051, 73239

Abstract:

A control program for a positive displacement metering system measures the time required for the travel of a free piston in a cylinder of known volume to determine an average flow rate during a full stroke of the piston. The system may also measure and record the inlet and outlet pressures or the differential pressure between the fluid inlet and outlet. The control program positions a four-way valve which may function as an adjustable metering orifice in response to the measured average flow rate and/or changes in the inlet and outlet pressures to achieve the desired flow rate. At the end of each stroke, the four-way valve is repositioned to reverse fluid flow through the metering cylinder. The system may revise the valve position settings for both forward and reverse strokes based on the measured time required for a full stroke at a certain valve position. In this way, the system automatically and iteratively compensates for changes in fluid properties and fluid pressure.

US Patent:

8591957, Nov 26, 2013

Filed:

Oct 25, 2007

Appl. No.:

11/924601

Inventors:

Gregory J. Archambeau - Puyallap WA, US
Anthony B. Wood - Dallas TX, US
Richard L. Watson - McPherson KS, US

Assignee:

Revalesio Corporation - Tacoma WA

International Classification:

A01N 39/00

US Classification:

424613

Abstract:

Particular embodiments disclosed herein relate to electrokinetically altered gas-enriched fluids, methods of making the same, systems for making the same and/or methods of treatment utilizing the gas-enriched fluids for eye related conditions and/or diseases. In certain embodiments, the electrokinetically altered gas-enriched fluid is oxygen-enriched water. Certain embodiments relate to cosmetic and/or therapeutic fluids and/or methods of treatment utilizing the fluids to treat a cosmetic and/or therapeutic symptom related to eye conditions and/or diseases.