Rob Meijers

US Patent:

20030190600, Oct 9, 2003

Filed:

Apr 5, 2002

Appl. No.:

10/118471

Inventors:

Kathryn Holmes - Golden CO, US
Bruce Zelus - Lakewood CO, US
Kemin Tan - Waltham MA, US
Jia-Huai Wang - Belmont MA, US
Rob Meijers - Somerville MA, US

International Classification:

A01N037/18
A61K038/00
C12Q001/70
G01N033/53
C07K001/00
C07K014/00
C07K017/00

US Classification:

435/005000, 435/007100, 530/350000, 514/002000

Abstract:

Disclosed are novel crystal structures of a carcinoembryonic cell adhesion antigen functional domain that is characterized as having a unique N-terminal domain structure, called a CC′ loop. This tertiary structure is used in a number of screening methods for identifying candidate molecules that have a binding affinity for the tertiary structure of the CC′ loop. Pharmaceutical preparations that include one or more of such identified candidate may then be provided and used in treatments for bacterial infections, dysentery, angiogenesis, immune cell mediated disease, and related conditions thereto.