Robert W Beck

US Patent:

6537820, Mar 25, 2003

Filed:

Oct 31, 2001

Appl. No.:

09/999394

Inventors:

Robert A. Beck - Framingham MA
Robert A. Mateer - North Uxbridge MA

Assignee:

Cromaceutical Advanced Technologies, Inc. - Hopkinton MA

International Classification:

G01N 3320

US Classification:

436 84, 436 8, 436 73, 436 94, 436161, 436164, 436175, 436177, 436178, 422 70, 210656, 2101982

Abstract:

A method for separating and purifying the active hematinic species present in iron-saccharidic complexes including sodium ferric gluconate complex in sucrose, ferric hydroxide-sucrose complex and ferric saccharate complex and others of similar form and function, based on separation of the iron-saccharidic complex from one or more excipients and, preferably, lyophilization. Separation of the iron-saccharidic complex permits its analytical quantification; further concentration or purification as a new and useful product; preparation of redesigned formulations for new and useful pharmaceuticals; and/or lyophilization. The ability to separate the iron-saccharidic complex responsible for hematinic function, including its lyophilized form, also provides a means for preparing analytical material to verify and validate its pharmacological integrity, patient safety and clinical performance, as well as analytical monitoring, standardization and quality control inspection over hematinic manufacturing processes and establishment of standards for use therewith.

US Patent:

6773924, Aug 10, 2004

Filed:

Feb 21, 2003

Appl. No.:

10/371783

Inventors:

Robert A. Beck - Framingham MA

Assignee:

Chromaceutical Advanced Technologies, Inc. - Hopkinton MA

International Classification:

G01N 3320

US Classification:

436 84, 436 8, 436 73, 436 94, 2524081, 514 23, 514184, 514502

Abstract:

A method for separating and purifying the active hematinic species present in iron-saccharidic complexes including sodium ferric gluconate complex in sucrose, ferric hydroxide-sucrose complex and ferric saccharate complex and others of similar form and function, based on separation of the iron-saccharidic complex from one or more excipients and, preferably, lyophilization. Separation of the iron-saccharidic complex permits its analytical quantification; further concentration or purification as a new and useful product; preparation of redesigned formulations for new and useful pharmaceuticals; and/or lyophilization. The ability to separate the iron-saccharidic complex responsible for hematinic function, including its lyophilized form, also provides a means for preparing analytical material to verify and validate its pharmacological integrity, patient safety and clinical performance, as well as analytical monitoring, standardization and quality control inspection over hematinic manufacturing processes and establishment of standards for use therewith.

US Patent:

6833087, Dec 21, 2004

Filed:

Oct 25, 2001

Appl. No.:

10/055799

Inventors:

Robert A. Beck - Framingham MA
Paul D. Manos - Pinehurst NC

Assignee:

Wonders of Water, LLC - Aberdeen NC
Intellectual Concepts, LLC - Lake Charles LA

International Classification:

C09K 300

US Classification:

2523891, 25238961, 252396, 252397, 252399, 2524001, 25240061, 252407

Abstract:

Compositions and methods are disclosed for preventing the oxidative corrosion of metal surfaces by exposing a metal surface to an anti-corrosion agent characterized as 2,4-trans, trans-hexadienoic acid (2,4-HDA), its alkali salt identified as potassium sorbate (KHDA), or other derivatives that conserve or embody the 2,4-trans, trans-hexadiene-type moiety present in their molecular structures as an active anti-corrosion agent (ACA), in combination with a material capable of forming a moisture retentive barrier over the metal surface. The compositions and methods of the invention provide a practical, non-toxic way of ensuring anti-corrosion protection for metals, or devices containing exposed metals, stored or operated in water or in the presence of water vapor. Exemplary, non-exhaustive uses of the invention include employing the composition as a lubricant for the surface of a metal or as a pump oil or brake fluid; using the composition as an undercoating for painting, electro-plating or electro-polishing procedures; and providing a protective coating for any metal or metal-containing machine or device, from automotive assembly plant metal press machines to electronic circuit boards.

US Patent:

6929954, Aug 16, 2005

Filed:

Jun 20, 2003

Appl. No.:

10/600173

Inventors:

Robert A. Beck - Framingham MA, US
Robert A. Mateer - North Uxbridge MA, US

Assignee:

Chromaceutical Advanced Technologies, Inc. - Hopkinton MA

International Classification:

G01N033/20

US Classification:

436 84, 436 8, 436 73, 436 94, 2524081, 514 23, 514184, 514502

Abstract:

A method for separating and purifying the active hematinic species (AHS) present in iron-saccharidic compositions, including AHS such as sodium ferric gluconate complex, ferric hydroxide-sucrose complex and ferric saccharate complex and others of similar form and function. The method separates the AHS from one or more excipients and, preferably, lyophilizes the separated AHS. Separation of the AHS permits its analytical quantification, further concentration, purification and/or lyophilization as well as preparation of new and useful products and pharmaceutical compositions.

US Patent:

6939715, Sep 6, 2005

Filed:

Jun 1, 2004

Appl. No.:

10/858163

Inventors:

Robert A. Beck - Framingham MA, US

Assignee:

Chromaceutical Advanced Technologies, Inc. - Hopkinton MA

International Classification:

G01N033/20
A61K031/715

US Classification:

436 84, 436 8, 436 73, 436 94, 436161, 436175, 436177, 436178, 422 70, 210656, 2101982, 2524081, 514 23, 514184, 514502

Abstract:

A method for separating and purifying the active hematinic species present in iron-saccharidic complexes including sodium ferric gluconate complex in sucrose, ferric hydroxide-sucrose complex and ferric saccharate complex and others of similar form and function, based on separation of the iron-saccharidic complex from one or more excipients and, preferably, lyophilization. Separation of the iron-saccharidic complex permits its analytical quantification; further concentration or purification as a new and useful product; preparation of redesigned formulations for new and useful pharmaceuticals; and/or lyophilization. The ability to separate the iron-saccharidic complex responsible for hematinic function, including its lyophilized form, also provides a means for preparing analytical material to verify and validate its pharmacological integrity, patient safety and clinical performance, as well as analytical monitoring, standardization and quality control inspection over hematinic manufacturing processes and establishment of standards for use therewith.

US Patent:

7687273, Mar 30, 2010

Filed:

Jul 7, 2005

Appl. No.:

11/176132

Inventors:

Robert A. Beck - Framingham MA, US

Assignee:

Chromaceutical Advanced Technologies, Inc. - Hopkinton MA

International Classification:

G01N 33/20

US Classification:

436 84, 436 73, 436 94, 436161, 436164, 436175, 422 70, 422 8205, 422 8209, 210656, 2101982, 514 23, 514184, 514502

Abstract:

A method for separating and purifying the active hematinic species (AHS) present in iron-saccharidic compositions, including AHS such as sodium ferric gluconate complex, ferric hydroxide-sucrose complex and ferric saccharate complex and others of similar form and function. The method separates the AHS from one or more excipients and, preferably, lyophilizes the separated AHS. Separation of the AHS permits its analytical quantification, further concentration, purification and/or lyophilization as well as preparation of new and useful products and pharmaceutical compositions, including those useful for the treatment of humans and animals.

US Patent:

7883897, Feb 8, 2011

Filed:

Feb 25, 2010

Appl. No.:

12/712394

Inventors:

Robert A. Beck - Framingham MA, US

Assignee:

Chromaceutical Advanced Technologies, Inc. - Hopkinton MA

International Classification:

G01N 33/20
A61K 31/295

US Classification:

436 84, 436 8, 436 73, 436 94, 2524081, 514 23, 514184, 514502

Abstract:

A method for separating and purifying the active hematinic species (AHS) present in iron-saccharidic compositions, including AHS such as sodium ferric gluconate complex, ferric hydroxide-sucrose complex and ferric saccharate complex and others of similar form and function. The method separates the AHS from one or more excipients and, preferably, lyophilizes the separated AHS. Separation of the AHS permits its analytical quantification, further concentration, purification and/or lyophilization as well as preparation of new and useful products and pharmaceutical compositions, including those useful for the treatment of humans and animals.

US Patent:

7964568, Jun 21, 2011

Filed:

May 26, 2004

Appl. No.:

10/853951

Inventors:

Robert A. Beck - Framingham MA, US
John Kowalski - Mansfield MA, US

Assignee:

Chromaceutical Advanced Technologies, Inc. - Hopkinton MA

International Classification:

A01N 43/04
A01N 31/00
A01N 55/02
A01N 59/16
A61K 31/70
A61K 31/715
A61K 31/045
A61K 31/29
A61K 33/26
C07C 59/10
C07C 59/285

US Classification:

514 25, 514 53, 514738, 514502, 424646, 562587

Abstract:

A process for preparing parenteral iron-saccharidic complexes, and the complexes produced, comprising: (1) providing an aqueous solution or dispersion including (i) Fe(III) and (OH) ions and (ii) at least one saccharide, to form a reaction mixture, where the molar ratio of (i): (ii) is about 30:1 to about 1:30; and the mixture temperature and pH are at or above the complex assembly point (CAP); and (2) maintaining temperature and pH at or above the CAP for a time sufficient to form an iron-saccharidic complex having a molecular weight of about 25,000 Daltons or more. Control of the temperature and pH efficiently produces a high molecular weight complex. The complex can be separated by precipitation, dialysis and/or column fractionation and, if desired, dried, e. g. , lyophilized or spray dried. The process can controllably synthesize complexes of varying molecular weight and/or chemical composition, particularly sodium ferric gluconate and ferric hydroxide-sucrose.