Robert Steven Becker

US Patent:

6379675, Apr 30, 2002

Filed:

Jan 19, 1996

Appl. No.:

08/588621

Inventors:

Robert S. Becker - Henryville PA
Robert C. Huebner - Stroudsburg PA
Maryann Gray - Bartonsville PA
Karen S. Biscardi - South Sterling PA
Lorne F. Erdile - Tassin la Demi Lune, FR
Bruno Guy - Lyons, FR

Assignee:

Connaught Laboratories, Inc. - Swiftwater PA

International Classification:

A61K 3902

US Classification:

4242341, 4241921, 4241931, 42419711, 4242371, 4242441, 530350, 435 691

Abstract:

Immunological compositions and methods for making and using them. The compositions contain at least one antigen and at least one lipoprotein and optionally an adjuvant. The lipoprotein can itself be antigenic or immunogenic. The antigen can be influenza HA and the lipoprotein a recombinantly expressed product having an OspA leader for lipidation and PspA for the protein portion. The antigen can be OspC and the lipoprotein OspA. The components of the composition are co-administered. A potentiated immunological response is obtained by the compositions and methods.

US Patent:

6538118, Mar 25, 2003

Filed:

Apr 28, 1998

Appl. No.:

09/067453

Inventors:

Robert C. Huebner - Stroudsburg PA
Lorne F. Erdile - Stroudsburg PA
Robert S. Becker - Henryville PA
Maryann B. Gray - Bartonsville PA
Derek J. Pyle - East Stroudsburg PA

Assignee:

Connaught Laboratories, Inc. - Swiftwater PA

International Classification:

C07H 2104

US Classification:

536 231, 536 234, 536 237, 435 691, 435 697, 4351723, 4353201

Abstract:

Heterologous lipidated proteins formed recombinantly are disclosed and claimed. The expression system can be. The heterologous lipidated protein has a leader sequence which does not naturally occur with the protein portion of the lipidated protein. The lipidated protein can have the Borrelia OspA leader sequence. The protein portion can be OspC, PspA, UreA, Ure B, or a fragment thereof. Methods and compositions for forming and employing the proteins are also disclosed and claimed.

US Patent:

6638516, Oct 28, 2003

Filed:

May 24, 1999

Appl. No.:

09/147875

Inventors:

Robert S. Becker - Henryville PA
David E. Briles - Birmingham AL
Susan Hollingshead - Birmingham AL

Assignee:

The UAB Research Foundation - Birmingham AL

International Classification:

A61K 3909

US Classification:

4242441, 424 9344, 4241651, 4242371, 530350, 536 237

Abstract:

The present invention relates to vaccine composition(s) comprising at least two PspAs from strains selected from at least one family, the family being defined by PspAs from strains belonging to the family having greater than or equal to 50% homology in aligned sequences of a C-terminal region of an alpha helical region of PspA. Additionally, the families are further comprised of clades, wherein PspAs from strains which belong to a clade exhibit at least 75% sequence homology in aligned sequences of the C-terminal region of the alpha helix of PspA. Vaccine compositions of the present invention preferably comprise a minimum of 4 and a maximum of 6 strains representing a single clade each, and the at least two PspAs are optionally serologically or broadly cross-reactive.

US Patent:

6984385, Jan 10, 2006

Filed:

Mar 12, 2002

Appl. No.:

10/096687

Inventors:

Robert S. Becker - Henryville PA, US
Robert C. Huebner - Stroudsburg PA, US
Maryann Gray - Bartonsville PA, US
Karen S. Biscardi - South Sterling PA, US
Lorne F. Erdile - Tassin la Demi Lune, FR
Bruno Guy - Lyons, FR

Assignee:

Connaught Laboratories, Inc. - Swiftwater PA

International Classification:

A61K 39/00

US Classification:

4241921, 4242341, 4241931, 42419711, 4242001, 4242011, 4242031, 4242371, 4242441, 530350, 435 691, 435 693, 435 697, 435 711

Abstract:

Immunological compositions and methods for making and using them. The compositions contain at least one antigen and at least one lipoprotein and optionally an adjuvant. The lipoprotein can itself be antigenic or immunogenic. The antigen can be influenza HA and the lipoprotein a recombinantly expressed product having an OspA leader for lipidation and PspA for the protein portion. The antigen can be OspC and the lipoprotein OspA. The components of the composition are co-administered. A potentiated immunological response is obtained by the compositions and methods.

US Patent:

7189404, Mar 13, 2007

Filed:

Sep 30, 2003

Appl. No.:

10/674755

Inventors:

Robert S. Becker - Henryville PA, US
David E. Briles - Birmingham AL, US
Susan Hollingshead - Birmingham AL, US

Assignee:

The UAB Research Foundation - Birmingham AL

International Classification:

A61K 39/09
G01N 33/569
C07K 1/00
C07H 21/04

US Classification:

4242441, 424 734, 424 9344, 4241651, 4242371, 530300, 530350, 536 237

Abstract:

The present invention relates to vaccine composition(s) comprising at least two PspAs from strains selected from at least one family, the family being defined by PspAs from strains belonging to the family having greater than or equal to 50% homology in aligned sequences of a C-terminal region of an alpha helical region of PspA. Additionally, the families are further comprised of clades, wherein PspAs from strains which belong to a clade exhibit greater than 75% sequence homology in aligned sequences of the C-terminal region of the alpha helix of PspA. Vaccine compositions of the present invention preferably comprise a minimum of 4 and a maximum of 6 strains representing a single clade each, and the at least two PspAs are optionally serologically or broadly cross-reactive.

US Patent:

7235243, Jun 26, 2007

Filed:

Jul 1, 2005

Appl. No.:

11/173364

Inventors:

Robert S. Becker - Henryville PA, US
Robert C. Huebner - Stroudsburg PA, US
Maryann Gray - Bartonsville PA, US
Karen S. Biscardi - South Sterling PA, US
Lorne F. Erdile - Tassin la Demi Lune, FR
Bruno Guy - Lyons, FR

Assignee:

Connaught Laboratories, Inc. - Swiftwater PA

International Classification:

A61K 39/00

US Classification:

4241921, 4241931, 42419711, 4242001, 4242011, 4242031, 4242341, 4242371, 4242441, 435 691, 435 693, 435 697, 435 711, 530350

Abstract:

Immununological compositions and methods for making and using them. The compositions contain at least one antigen and at least one lipoprotein and optionally an adjuvant. The lipoprotein can itself be antigenic or immunogenic. The antigen can be influenza HA and the lipoprotein a recombinantly expressed product having an OspA leader for lipidation and PspA for the protein portion. The antigen can be OspC and the lipoprotein OspA. The components of the composition are co-administered. A potentiated immunological response is obtained by the compositions and methods.

US Patent:

20050171343, Aug 4, 2005

Filed:

Feb 6, 2003

Appl. No.:

10/359435

Inventors:

Robert Huebner - Stroudsburg PA, US
Lorne Erdile - Stroudsburg PA, US
Donald Warakomski - Tannersville PA, US
Robert Becker - Henryville PA, US
Maryann Gray - Bartonsville PA, US
Derek Pyle - East Stroudsburg PA, US

International Classification:

C12Q001/68
C07H021/04
C12N015/09
A61K039/02
C07K014/195
C12N001/21

US Classification:

536023700, 424190100, 435006000, 435069300, 435252300, 435320100, 530359000

Abstract:

Heterologous lipidated proteins formed recombinantly are disclosed and claimed. The expression system can be The heterologous lipidated protein has a leader sequence which does not naturally occur with the protein portion of the lipidated protein. The lipidated protein can have the OspA leader sequence. The protein portion can be OspC, PspA, UreA, Ure B, or a fragment thereof. Methods and compositions for forming and employing the proteins are also disclosed and claimed.

US Patent:

20080089911, Apr 17, 2008

Filed:

May 18, 2007

Appl. No.:

11/804446

Inventors:

Robert Becker - Henryville PA, US
Robert Huebner - Stroudeburg PA, US
Maryann Gray - Bartonsville PA, US
Karen Biscardi - South Sterling PA, US
Lorne Erdile - Tassin La Demi Lune, FR
Bruno Guy - Lyon, FR

International Classification:

A61K 39/02
A61P 37/00

US Classification:

424234100

Abstract:

Immununological compositions and methods for making and using them. The compositions contain at least one antigen and at least one lipoprotein and optionally an adjuvant. The lipoprotein can itself be antigenic or immunogenic. The antigen can be influenza HA and the lipoprotein a recombinantly expressed product having an OspA leader for lipidation and PspA for the protein portion. The antigen can be OspC and the lipoprotein OspA. The components of the composition are co-administered. A potentiated immunological response is obtained by the compositions and methods.