Robert A Bowles

US Patent:

20210213168, Jul 15, 2021

Filed:

Nov 25, 2020

Appl. No.:

17/105154

Inventors:

- Ithaca NY, US
Roger HARTL - New York NY, US
Robert D. BOWLES - Ithaca NY, US
Harry H. GEBHARD - Tuebingen, DE

International Classification:

A61L 27/36
A61K 35/32
A61L 27/20
A61L 27/24
A61L 27/38
A61L 27/52
A61F 2/44
A61L 27/22
A61L 27/44

Abstract:

The present invention relates to a tissue-engineered intervertebral disc (IVD) suitable for total disc replacement in a mammal and methods of fabrication. The IVD comprises a nucleus pulposus structure comprising a first population of living cells that secrete a hydrophilic protein and an annulus fibrosis structure surrounding and in contact with the nucleus pulposus structure, the annulus fibrosis structure comprising a second population of living cells and type I collagen. The collagen fibrils in the annulus fibrosis structure are circumferentially aligned around the nucleus pulposus region due to cell-mediated contraction in the annulus fibrosis structure. Also disclosed are methods of fabricating tissue-engineered intervertebral discs.

US Patent:

20190365949, Dec 5, 2019

Filed:

Jun 16, 2019

Appl. No.:

16/442535

Inventors:

- Ithaca NY, US
Roger HARTL - New York NY, US
Robert D. BOWLES - Ithaca NY, US
Harry H. GEBHARD - Tuebingen, DE

International Classification:

A61L 27/36
A61K 35/32
A61L 27/20
A61L 27/24
A61L 27/38
A61L 27/52
A61F 2/44
A61L 27/22
A61L 27/44

Abstract:

The present invention relates to a tissue-engineered intervertebral disc (IVD) suitable for total disc replacement in a mammal and methods of fabrication. The IVD comprises a nucleus pulposus structure comprising a first population of living cells that secrete a hydrophilic protein and an annulus fibrosis structure surrounding and in contact with the nucleus pulposus structure, the annulus fibrosis structure comprising a second population of living cells and type I collagen. The collagen fibrils in the annulus fibrosis structure are circumferentially aligned around the nucleus pulposus region due to cell-mediated contraction in the annulus fibrosis structure. Also disclosed are methods of fabricating tissue-engineered intervertebral discs.

US Patent:

20170290953, Oct 12, 2017

Filed:

Apr 26, 2017

Appl. No.:

15/497406

Inventors:

- Ithaca NY, US
Roger Hartl - New York NY, US
Robert D. Bowles - Ithaca NY, US
Harry H. Gebhard - Tuebingen, DE

International Classification:

A61L 27/38
A61F 2/44
A61L 27/44
A61L 27/36
A61L 27/24
A61L 27/20

Abstract:

The present invention relates to a tissue-engineered intervertebral disc (IVD) suitable for total disc replacement in a mammal and methods of fabrication. The IVD comprises a nucleus pulposus structure comprising a first population of living cells that secrete a hydrophilic protein and an annulus fibrosis structure surrounding and in contact with the nucleus pulposus structure, the annulus fibrosis structure comprising a second population of living cells and type I collagen. The collagen fibrils in the annulus fibrosis structure are circumferentially aligned around the nucleus pulposus region due to cell-mediated contraction in the annulus fibrosis structure. Also disclosed are methods of fabricating tissue-engineered intervertebral discs.

US Patent:

20150238657, Aug 27, 2015

Filed:

May 12, 2015

Appl. No.:

14/710330

Inventors:

- Ithaca NY, US
Roger Hartl - New York NY, US
Robert D. Bowles - Ithaca NY, US
Harry H. Gebhard - Tuebingen, DE

International Classification:

A61L 27/36
A61L 27/44
A61L 27/22
A61L 27/24

Abstract:

The present invention relates to a tissue-engineered intervertebral disc (IVD) suitable for total disc replacement in a mammal and methods of fabrication. The IVD comprises a nucleus pulposus structure comprising a first population of living cells that secrete a hydrophilic protein and an annulus fibrosis structure surrounding and in contact with the nucleus pulposus structure, the annulus fibrosis structure comprising a second population of living cells and type I collagen. The collagen fibrils in the annulus fibrosis structure are circumferentially aligned around the nucleus pulposus region due to cell-mediated contraction in the annulus fibrosis structure. Also disclosed are methods of fabricating tissue-engineered intervertebral discs.