Robert Daniel Bowles

US Patent:

20130079881, Mar 28, 2013

Filed:

May 5, 2010

Appl. No.:

13/319025

Inventors:

Lawrence J. Bonassar - Ithaca NY, US
Roger Hartl - New York NY, US
Robert D. Bowles - Ithaca NY, US
Harry H. Gebhard - Tuebingen, DE

Assignee:

CORNELL UNIVERSITY - Ithaca NY

International Classification:

A61F 2/44

US Classification:

623 1716, 435325, 435366, 435354, 435350, 2643281

Abstract:

The present invention relates to a tissue-engineered intervertebral disc (IVD) suitable for total disc replacement in a mammal and methods of fabrication. The IVD comprises a nucleus pulposus structure comprising a first population of living cells that secrete a hydrophilic protein and an annulus fibrosis structure surrounding and in contact with the nucleus pulposus structure, the annulus fibrosis structure comprising a second population of living cells and type I collagen. The collagen fibrils in the annulus fibrosis structure are circumferentially aligned around the nucleus pulposus region due to cell-mediated contraction in the annulus fibrosis structure. Also disclosed are methods of fabricating tissue-engineered intervertebral discs.

US Patent:

20210213168, Jul 15, 2021

Filed:

Nov 25, 2020

Appl. No.:

17/105154

Inventors:

- Ithaca NY, US
Roger HARTL - New York NY, US
Robert D. BOWLES - Ithaca NY, US
Harry H. GEBHARD - Tuebingen, DE

International Classification:

A61L 27/36
A61K 35/32
A61L 27/20
A61L 27/24
A61L 27/38
A61L 27/52
A61F 2/44
A61L 27/22
A61L 27/44

Abstract:

The present invention relates to a tissue-engineered intervertebral disc (IVD) suitable for total disc replacement in a mammal and methods of fabrication. The IVD comprises a nucleus pulposus structure comprising a first population of living cells that secrete a hydrophilic protein and an annulus fibrosis structure surrounding and in contact with the nucleus pulposus structure, the annulus fibrosis structure comprising a second population of living cells and type I collagen. The collagen fibrils in the annulus fibrosis structure are circumferentially aligned around the nucleus pulposus region due to cell-mediated contraction in the annulus fibrosis structure. Also disclosed are methods of fabricating tissue-engineered intervertebral discs.

US Patent:

20190365949, Dec 5, 2019

Filed:

Jun 16, 2019

Appl. No.:

16/442535

Inventors:

- Ithaca NY, US
Roger HARTL - New York NY, US
Robert D. BOWLES - Ithaca NY, US
Harry H. GEBHARD - Tuebingen, DE

International Classification:

A61L 27/36
A61K 35/32
A61L 27/20
A61L 27/24
A61L 27/38
A61L 27/52
A61F 2/44
A61L 27/22
A61L 27/44

Abstract:

The present invention relates to a tissue-engineered intervertebral disc (IVD) suitable for total disc replacement in a mammal and methods of fabrication. The IVD comprises a nucleus pulposus structure comprising a first population of living cells that secrete a hydrophilic protein and an annulus fibrosis structure surrounding and in contact with the nucleus pulposus structure, the annulus fibrosis structure comprising a second population of living cells and type I collagen. The collagen fibrils in the annulus fibrosis structure are circumferentially aligned around the nucleus pulposus region due to cell-mediated contraction in the annulus fibrosis structure. Also disclosed are methods of fabricating tissue-engineered intervertebral discs.

US Patent:

20180155715, Jun 7, 2018

Filed:

Jun 17, 2016

Appl. No.:

15/737516

Inventors:

Robert D. Bowles - Salt Lake City UT, US
Niloofar Farhang - Salt Lake City UT, US
Joshua Stover - Salt Lake City UT, US
Lori Setton - Durham NC, US
Farshid Guilak - Durham NC, US
Charles Gersbach - Durham NC, US
Jonathan Brunger - Durham NC, US

International Classification:

C12N 15/11
C12N 9/22
C12N 15/85
A61P 19/02

Abstract:

Described herein are compositions and methods for treatment and prevention of low back pain. The compositions include vectors comprising nucleotide sequences encoding one or more CRISPR-Cas system guide RNAs and a RNA-directed nuclease. The methods include modulating expression of a gene in a cell using said compositions, introducing a CRISPR-Cas system into a cell comprising one or more vectors comprising said compositions, inducing site-specific DNA cleavage in a cell, and treating a subject having lower back pain, and lower back pain caused by degenerative disc disease using the compositions disclosed herein.

US Patent:

20170290953, Oct 12, 2017

Filed:

Apr 26, 2017

Appl. No.:

15/497406

Inventors:

- Ithaca NY, US
Roger Hartl - New York NY, US
Robert D. Bowles - Ithaca NY, US
Harry H. Gebhard - Tuebingen, DE

International Classification:

A61L 27/38
A61F 2/44
A61L 27/44
A61L 27/36
A61L 27/24
A61L 27/20

Abstract:

The present invention relates to a tissue-engineered intervertebral disc (IVD) suitable for total disc replacement in a mammal and methods of fabrication. The IVD comprises a nucleus pulposus structure comprising a first population of living cells that secrete a hydrophilic protein and an annulus fibrosis structure surrounding and in contact with the nucleus pulposus structure, the annulus fibrosis structure comprising a second population of living cells and type I collagen. The collagen fibrils in the annulus fibrosis structure are circumferentially aligned around the nucleus pulposus region due to cell-mediated contraction in the annulus fibrosis structure. Also disclosed are methods of fabricating tissue-engineered intervertebral discs.

US Patent:

20150238657, Aug 27, 2015

Filed:

May 12, 2015

Appl. No.:

14/710330

Inventors:

- Ithaca NY, US
Roger Hartl - New York NY, US
Robert D. Bowles - Ithaca NY, US
Harry H. Gebhard - Tuebingen, DE

International Classification:

A61L 27/36
A61L 27/44
A61L 27/22
A61L 27/24

Abstract:

The present invention relates to a tissue-engineered intervertebral disc (IVD) suitable for total disc replacement in a mammal and methods of fabrication. The IVD comprises a nucleus pulposus structure comprising a first population of living cells that secrete a hydrophilic protein and an annulus fibrosis structure surrounding and in contact with the nucleus pulposus structure, the annulus fibrosis structure comprising a second population of living cells and type I collagen. The collagen fibrils in the annulus fibrosis structure are circumferentially aligned around the nucleus pulposus region due to cell-mediated contraction in the annulus fibrosis structure. Also disclosed are methods of fabricating tissue-engineered intervertebral discs.