Robert L Bowles

US Patent:

20180155715, Jun 7, 2018

Filed:

Jun 17, 2016

Appl. No.:

15/737516

Inventors:

Robert D. Bowles - Salt Lake City UT, US
Niloofar Farhang - Salt Lake City UT, US
Joshua Stover - Salt Lake City UT, US
Lori Setton - Durham NC, US
Farshid Guilak - Durham NC, US
Charles Gersbach - Durham NC, US
Jonathan Brunger - Durham NC, US

International Classification:

C12N 15/11
C12N 9/22
C12N 15/85
A61P 19/02

Abstract:

Described herein are compositions and methods for treatment and prevention of low back pain. The compositions include vectors comprising nucleotide sequences encoding one or more CRISPR-Cas system guide RNAs and a RNA-directed nuclease. The methods include modulating expression of a gene in a cell using said compositions, introducing a CRISPR-Cas system into a cell comprising one or more vectors comprising said compositions, inducing site-specific DNA cleavage in a cell, and treating a subject having lower back pain, and lower back pain caused by degenerative disc disease using the compositions disclosed herein.