Robert H Butz

US Patent:

43471781, Aug 31, 1982

Filed:

Apr 14, 1980

Appl. No.:

6/140160

Inventors:

John W. A. Findlay - Chapel Hill NC
Robert F. Butz - Durham NC
Richard M. Welch - Raleigh NC

Assignee:

Burroughs Wellcome Co. - Research Triangle Park NC

International Classification:

C07C12300
C07C13100
G01N 3354

US Classification:

260112B

Abstract:

A radioimmunoassay procedure has been discovered for bupropion [(. +-. )-2-t-butylamino-3-chloropropiophenone], an antidepressant compound, in biological fluids. Novel compounds of formula ##STR1## wherein either R. sub. 2 is oxygen and R. sub. 1 is (CH. sub. 2). sub. n -O-(CO). sub. m -(CH. sub. 2). sub. p -COOH where n is an integer from 0 to 5, m is 0 or 1, and p is an integer from 1 to 4; or R. sub. 1 is hydrogen and R. sub. 2 is N-O-(CH. sub. 2). sub. q -COOH where q is an integer from 1 to 3, and novel methods of making them and novel intermediates useful therein are disclosed. Novel immunogens for raising bupropion specific antisera, and novel methods of making them are disclosed comprising conjugates of the novel compounds and suitable carrier material. The drug is added to the antisera together with novel radiolabeled competitor of formula ##STR2## wherein R' is a suitable radioisotope as described above and R. sub. 3 is hydrogen, R. sub.

US Patent:

43551793, Oct 19, 1982

Filed:

Apr 14, 1980

Appl. No.:

6/140165

Inventors:

John W. A. Findlay - Chapel Hill NC
Robert F. Butz - Durham NC
Richard M. Welch - Raleigh NC

Assignee:

Burroughs Wellcome Co. - Research Triangle Park NC

International Classification:

C07C 25024
C07C10330
C07G 700
G01N 3354

US Classification:

564177

Abstract:

A radioimmunoassay procedure has been discovered for bupropion [(. +-. )-2-t-butylamino-3-chloropropiophenone], an antidepressant compound, in biological fluids. Novel compounds of formula ##STR1## wherein either R. sub. 2 is oxygen and R. sub. 1 is (CH. sub. 2). sub. n --O--(CO). sub. m --(CH. sub. 2). sub. p --COOH where n is an integer from 0 to 5, m is 0 or 1, and p is an integer from 1 to 4; or R. sub. 1 is hydrogen and R. sub. 2 is N--O--(CH. sub. 2). sub. q --COOH where q is an integer from 1 to 3, and novel methods of making them and novel intermediates useful therein are disclosed. Novel immunogens for raising bupropion specific antisera, and novel methods of making them are disclosed comprising conjugates of the novel compounds and suitable carrier material. The drug is added to the antisera together with novel radiolabeled competitor of formula ##STR2## wherein R' is a suitable radioisotope as described above and R. sub. 3 is hydrogen, R. sub.

US Patent:

43561659, Oct 26, 1982

Filed:

Apr 14, 1980

Appl. No.:

6/140158

Inventors:

John W. A. Findlay - Chapel Hill NC
Robert F. Butz - Durham NC
Richard M. Welch - Raleigh NC

Assignee:

Burroughs Wellcome Co. - Research Triangle Park NC

International Classification:

G01N 3356
G01N 3360
B65D 7100

US Classification:

424 1

Abstract:

A radioimmunoassay proceedure has been discovered for bupropion [(. +-. )-2-t-butylamino-3-chloropropiophenone], an antidepressant compound, in biological fluids. Novel compounds of formula ##STR1## wherein either R. sub. 2 is oxygen and R. sub. 1 is (CH. sub. 2). sub. n --O--(CO). sub. m --(CH. sub. 2). sub. p --COOH where n is an integer from 0 to 5, m is 0 or 1, and p is an integer from 1 to 4; or R. sub. 1 is hydrogen and R. sub. 2 is N--O--(CH. sub. 2). sub. q --COOH where Q is an integer from 1 to 3, and novel methods of making them and novel intermediates useful therein are disclosed. Novel immunogens for raising bupropion specific antisera, and novel methods of making them are disclosed comprising conjugates of the novel compounds and suitable carrier material. The drug is added to the antisera together with novel radiolabeled competitor of formula ##STR2## wherein R' is a suitable radioisotope as described above and R. sub. 3 is hydrogen, R. sub.