Robert L Devault

US Patent:

42184410, Aug 19, 1980

Filed:

Mar 29, 1979

Appl. No.:

6/025240

Inventors:

Ronald E. Carney - Gurnee IL
Robert L. DeVault - Libertyville IL
James B. McAlpine - Libertyville IL
Arthur C. Sinclair - Lake Forest IL

Assignee:

Abbott Laboratories - North Chicago IL

International Classification:

A61K 3171
C07H 1522

US Classification:

424180

Abstract:

A new seldomycin factor 5 derivative is provided, O-demethylseldomycin factor 5. The compound is represented by the formula: ##STR1## The compound is a potent anti-bacterial agent.

US Patent:

42230241, Sep 16, 1980

Filed:

Mar 12, 1979

Appl. No.:

6/019982

Inventors:

James B. McAlpine - Libertyville IL
Robert L. DeVault - Libertyville IL

Assignee:

Abbott Laboratories - North Chicago IL

International Classification:

A61K 3171
C07H 1522

US Classification:

424180

Abstract:

4"-O-alkylgentamicins and sagamicins represented by the formula: ##STR1## wherein R. sub. 1 is hydrogen or methyl: R. sub. 2 is hydrogen or methyl; R. sub. 3 is hydrogen or hydroxy; R. sub. 4 is hydroxy when R. sub. 3 is hydrogen and hydrogen when R. sub. 3 is hydroxy; and R. sub. 5 is loweralkyl; and the pharmaceutically acceptable salts thereof, intermediates therefor, and compositions and methods employing the potent antibiotics of this invention.

US Patent:

42397529, Dec 16, 1980

Filed:

Mar 29, 1979

Appl. No.:

6/025255

Inventors:

Ronald E. Carney - Gurnee IL
Robert L. Devault - Libertyville IL
James B. McAlpine - Libertyville IL
Arthur C. Sinclair - Lake Forest IL

Assignee:

Abbott Laboratories - North Chicago IL

International Classification:

A61K 3171
C07H 1522

US Classification:

424180

Abstract:

Derivatives of O-demethylseldomycin factor 5 represented by the following formula are provided: ##STR1## wherein: R is hydrogen or loweralkyl; R. sub. 1 and R. sub. 2 can be either hydrogen or hydroxy with the limitation that both R. sub. 1 and R. sub. 2 cannot be hydroxy; R. sub. 3 is selected from the group consisting of hydrogen, loweralkyl, aminoloweralkyl, diaminoloweralkyl, hydroxyloweralkyl, N-loweralkylaminoloweralkyl, aminohydroxyloweralkyl, N-loweralkylaminohydroxyloweralkyl, or ##STR2## with the limitation that when R. sub. 1 is hydroxy, R. sub. 3 cannot be hydrogen when R is hydrogen; and R. sub. 4 is selected from the group consisting of loweralkyl, aminoloweralkyl, diaminoloweralkyl, hydroxyloweralkyl, N-loweralkylaminoloweralkyl, aminohydroxyloweralkyl and N-loweralkylaminohydroxyloweralkyl; and the pharmaceutically acceptable salts thereof. The compounds are potent anti-bacterial agents.