Robert J Devlin

US Patent:

58467033, Dec 8, 1998

Filed:

Mar 23, 1993

Appl. No.:

8/035633

Inventors:

Robert F. Devlin - San Diego CA
Walter B. Dandliker - La Jolla CA
Peter O. G. Arrhenius - San Diego CA

Assignee:

Diatron Corporation - San Diego CA

International Classification:

G01N 33533

US Classification:

435 5

Abstract:

Fluorescence immunoassays methods are provided which use fluorescent dyes which are free of aggregation and serum binding. Such immunoassay methods are thus, particularly useful for the assay of biological fluids, such as serum, plasma, whole blood and urine.

US Patent:

56060459, Feb 25, 1997

Filed:

Apr 21, 1993

Appl. No.:

8/051446

Inventors:

Walter B. Dandliker - La Jolla CA
Robert F. Devlin - San Diego CA

Assignee:

Diatron Corporation - San Diego CA

International Classification:

C07H 2102
C07H 2104

US Classification:

536 2532

Abstract:

The present invention is directed to compositions comprising an oligonucleotide linked to a detectably labeled marker component comprising a fluorophore moiety which comprises a substantially planar, multidentate macrocyclic ligand coordinated to a central atom capable of coordinating with two axial ligands and two polyoxyhydrocarbyl moieties which are attached as axial ligands to the central atom. The present invention is also directed to nucleic acid hybridization and amplification methods employing such compositions.

US Patent:

58802878, Mar 9, 1999

Filed:

Jun 7, 1995

Appl. No.:

8/476544

Inventors:

Walter B. Dandliker - La Jolla CA
Robert Francis Devlin - San Diego CA
Peter Olaf Gustaf Arrhenius - San Diego CA
Mao-Lin Hsu - Fountain Valley CA

Assignee:

Hyperion, Inc. - Miami FL

International Classification:

C09B 2300
C07D51302

US Classification:

548156

Abstract:

Fluorescent dyes which are free of aggregation and serum binding are provided. These dyes are suitable for applications such as fluorescence immunoassays, in vivo imaging and in vivo tumor therapy. Fluorescence immunoassays methods are provided which use fluorescent dyes which are free of aggregation and serum binding. Such immunoassay methods are thus, particularly useful for the assay of biological fluids, such as serum, plasma, whole blood and urine. The present invention is directed to compositions comprising an oligonucleotide linked to a detectably labeled marker component comprising a fluorophore moiety which comprises a substantially planar, multidentate macrocyclic ligand coordinated to a central atom capable of coordinating with two axial ligands and two polyoxyhydrocarbyl moieties which are attached as axial ligands to the central atom. The present invention is also directed to nucleic acid hybridization and amplification methods employing such compositions.

US Patent:

57078130, Jan 13, 1998

Filed:

Sep 6, 1996

Appl. No.:

8/709285

Inventors:

Walter B. Dandliker - La Jolla CA
Robert F. Devlin - San Diego CA

Assignee:

Diatron Corporation - San Diego CA

International Classification:

C12Q 168
C12P 1934

US Classification:

435 6

Abstract:

The present invention is directed to compositions comprising an oligonucleotide linked to a detectably labeled marker component comprising a fluorophore moiety which comprises a substantially planar, multidentate macrocyclic ligand coordinated to a central atom capable of coordinating with two axial ligands and two polyoxyhydrocarbyl moieties which are attached as axial ligands to the central atom. The present invention is also directed to nucleic acid hybridization and amplification methods employing such compositions.

US Patent:

60605987, May 9, 2000

Filed:

Jun 13, 1997

Appl. No.:

8/874820

Inventors:

Robert Francis Devlin - San Diego CA
Walter Beach Dandliker - La Jolla CA
Peter Olaf Gustaf Arrhenius - San Diego CA

Assignee:

Hyperion, Inc. - Miami FL

International Classification:

C07D48722

US Classification:

540122

Abstract:

Fluorescence immunoassays methods are provided which use fluorescent dyes which are free of aggregation and serum binding. Such immunoassay methods are thus, particularly useful for the assay of biological fluids, such as serum, plasma, whole blood and urine.