Robert W Ernst

US Patent:

20200121705, Apr 23, 2020

Filed:

Oct 4, 2017

Appl. No.:

16/339313

Inventors:

Robert K. Ernst - Silver Spring MD, US
Erin M. Harberts - Phoenix MD, US
Alison J. Scott - Silver Spring MD, US

Assignee:

University of Maryland, Baltimore - Baltimore MD

International Classification:

A61K 31/7016
C07H 13/06
A61P 29/00
A61P 31/00
G01N 33/53
A61K 9/00

Abstract:

The present invention provides a method of treating sepsis in a subject, comprising administering to the subject an effective amount of a compound of the formula wherein Rand Rmay be H, OH, protonated phosphate, a phosphate salt, a sugar phosphonate, or a mono-, di- or poly-saccharide, Rmay be OH or a mono-, di- or poly-saccharide, R, R, Rand Rmay be an alkyl or alkenyl chain of up to 13 carbons (for a chain of 16 carbons), and R, R, Rand Rmay be H, OH, or an alkyl or alkenyl ester of up to 16 carbons, or a salt thereof.

US Patent:

20170211120, Jul 27, 2017

Filed:

Jan 20, 2017

Appl. No.:

15/410948

Inventors:

Robert K. Ernst - Silver Spring MD, US
David Goodlett - Baltimore MD, US
Lisa Leung - Laurel MD, US

Assignee:

University of Maryland, Baltimore - Baltimore MD

International Classification:

C12Q 1/04
H01J 49/00
G01N 33/92
G01N 27/62
C12Q 1/18
G01N 33/49

Abstract:

Provided herein are methods for rapidly identifying a microbe, such as a pathogen, from a biological sample including, blood, urine, wound effluent, stool, serum, and bronchoalveolar lavage fluid. The method comprises obtaining the sample from the subject and performing a spectrometric analysis of the lipids in the microbe to obtain a profile. The profile obtained is compared with a molecular mass lipid profile of known microbes for identification. Also provided is a method for identifying one or more antimicrobial drugs effective to treat a microbial strain in a subject.

US Patent:

20160215322, Jul 28, 2016

Filed:

Oct 9, 2014

Appl. No.:

15/026400

Inventors:

- Baltimore MD, US
Robert ERNST - Silver Spring MD, US

Assignee:

UNIVERSITY OF MARYLAND, BALTIMORE - Baltimore MD

International Classification:

C12Q 1/04
C40B 30/02

Abstract:

Methods for identifying fungal species by analysis of fungal membrane lipids, such as glycerophospholipids, sphingolipids and sterols, using mass spectrometry ionization patterns are disclosed.