Robert E Erwin

US Patent:

6384771, May 7, 2002

Filed:

Apr 25, 2000

Appl. No.:

09/558275

Inventors:

Warren J. Montague - Redondo Beach CA
Garin S. Bircsak - North Hollywood CA
John K. Keigharn - Rancho Palos Verdes CA
Jorge L. Barboza - Buena Park CA
Robert W. Erwin - Redondo Beach CA

Assignee:

Raytheon Company - Lexington MA

International Classification:

G01S 740

US Classification:

342170, 342165, 342169, 342171, 342172, 342195

Abstract:

An automated simulator for radar and sonar applications. The inventive simulator is implemented in hardware and generates current parameters with respect to a simulated target in response to a plurality of initial values with respect thereto. In the illustrative embodiment, the initial values include range, velocity, and acceleration and are stored in first, second and third register respectively. In the best mode, the invention is implemented in a field-programmable gate array. The inventive target simulator also includes a range delay circuit for generating a simulated return from the simulated target. The range delay circuit includes logic for determining whether a simulated pulse train to be received is ambiguous or unambiguous and adjusting the pulse repetition rate of the pulse train accordingly. The range delay circuit calculates die initial time that a packet needs to make the trip to and from the target. Then, in the ambiguous case, the circuit only calculates how long it takes between pulses to arrive rather than the entire round trip.

US Patent:

20030027173, Feb 6, 2003

Filed:

Feb 5, 2002

Appl. No.:

10/072438

Inventors:

Guy Della-Cioppa - Vacaville CA, US
Robert Erwin - Vacaville CA, US
Wayne Fitzmaurice - Vacaville CA, US
Kathleen Hanley - Vacaville CA, US
Monto Kumagai - Davis CA, US
John Lindbo - Vacaville CA, US
David McGee - Vacaville CA, US
Hal Padgett - Vacaville CA, US
Gregory Pogue - Vacaville CA, US

International Classification:

C12Q001/68
A01H005/00

US Classification:

435/006000, 800/278000

Abstract:

The present invention provides methods for rapidly determining the function of nucleic acid sequences by transfecting the same into a host organism to effect expression. Phenotypic and biochemical changes produced thereby are then analyzed to ascertain the function of the nucleic acids which have been transfected into the host organism. The invention also provides methods for silencing endogenous genes by transfecting hosts with nucleic acid sequences to effect expression of the same. The present invention also provides methods for selecting desired functions of RNAs and proteins by the use of virus vectors to express libraries of nucleic acid sequence variants. Moreover, the present invention provides methods for inhibiting an endogenous protease of a plant host.

US Patent:

20040016021, Jan 22, 2004

Filed:

Jun 23, 2003

Appl. No.:

10/602219

Inventors:

Thomas Turpen - Vacaville CA, US
Gregory Pogue - Vacaville CA, US
Robert Erwin - Davis CA, US
Laurence Grill - Vacaville CA, US

International Classification:

A01H001/00
C12N007/00
C07H021/04
C12N009/40
C12N015/87
C12N005/04

US Classification:

800/280000, 800/284000, 435/419000, 435/208000, 536/023200, 435/235100

Abstract:

The invention relates to -galactosidase truncated at the carboxy terminus and the production of enzymatically active recombinant human and animal lysosomal enzymes involving construction and expression of recombinant expression constructs comprising coding sequences of human or animal lysosomal enzymes in a plant expression system. The plant expression system provides for post-translational modification and processing to produce a recombinant gene product exhibiting enzymatic activity. The invention is demonstrated by working examples in which transgenic tobacco plants express recombinant expression constructs comprising human glucocerebrosidase nucleotide sequences. The invention is also demonstrated by working examples in which transfected tobacco plants express recombinant viral expression constructs comprising human galactosidase nucleotide sequences. The recombinant lysosomal enzymes produced in accordance with the invention may be used for a variety of purposes, including but not limited to enzyme replacement therapy for the therapeutic treatment of human and animal lysosomal storage diseases.

US Patent:

20040023281, Feb 5, 2004

Filed:

Jun 23, 2003

Appl. No.:

10/602220

Inventors:

Thomas Turpen - Vacaville CA, US
Monto Kumagai - Kailua HI, US
Gregory Pogue - Vacaville CA, US
Robert Erwin - Davis CA, US
Laurence Grill - Vacaville CA, US

International Classification:

C12Q001/68
C07H021/04
C12N009/40
C12P021/02
C12N005/04

US Classification:

435/006000, 435/069100, 435/208000, 435/320100, 435/419000, 536/023200

Abstract:

The invention relates to -galactosidase truncated at the carboxy terminus and the production of enzymatically active recombinant human and animal lysosomal enzymes involving construction and expression of recombinant expression constructs comprising coding sequences of human or animal lysosomal enzymes in a plant expression system. The plant expression system provides for post-translational modification and processing to produce a recombinant gene product exhibiting enzymatic activity. The invention is demonstrated by working examples in which transgenic tobacco plants express recombinant expression constructs comprising human glucocerebrosidase nucleotide sequences. The invention is also demonstrated by working examples in which transfected tobacco plants express recombinant viral expression constructs comprising human galactosidase nucleotide sequences. The recombinant lysosomal enzymes produced in accordance with the invention may be used for a variety of purposes, including but not limited to enzyme replacement therapy for the therapeutic treatment of human and animal lysosomal storage diseases.

US Patent:

20040064855, Apr 1, 2004

Filed:

Oct 9, 2003

Appl. No.:

10/684300

Inventors:

Gregory Pogue - Vacaville CA, US
Thomas Turpen - Vacaville CA, US
Monto Kumagai - Kailua HI, US
Robert Erwin - Davis CA, US
Laurence Grill - Vacaville CA, US

Assignee:

LARGE SCALE BIOLOGY CORPORATION - Vacaville CA

International Classification:

C12N009/36
A01H001/00
C12N015/82
A01H005/00

US Classification:

800/288000, 800/317300, 435/206000

Abstract:

The invention relates to the production of enzymatically active recombinant human and animal lysosomal enzymes involving construction and expression of recombinant expression constructs comprising coding sequences of human or animal lysosomal enzymes in a plant expression system. The plant expression system provides for post-translational modification and processing to produce a recombinant gene product exhibiting enzymatic activity. The invention is demonstrated by working examples in which transgenic tobacco plants express recombinant expression constructs comprising human glucocerebrosidase nucleotide sequences. The invention is also demonstrated by working examples in which transfected tobacco plants express recombinant viral expression constructs comprising human galactosidase nucleotide sequences. The recombinant lysosomal enzymes produced in accordance with the invention may be used for a variety of purposes, including but not limited to enzyme replacement therapy for the therapeutic treatment of human and animal lysosomal storage diseases.

US Patent:

20050005319, Jan 6, 2005

Filed:

Jul 16, 2004

Appl. No.:

10/893056

Inventors:

Guy della-Cioppa - Vacaville CA, US
Robert Erwin - Davis CA, US
Wayne Fitzmaurice - Vacaville CA, US
Kathleen Hanley - Vacaville CA, US
Moaro Kumagai - Kailua HI, US
John Lindbo - Vacaville CA, US
David McGee - Vacaville CA, US
Hal Padgett - Vacaville CA, US
Gregory Pogue - Vacaville CA, US

Assignee:

LARGE SCALE BIOLOGY CORPORATION - Vacaville CA

International Classification:

A01H001/00
C12N015/82
C12N015/87

US Classification:

800260000, 800278000

Abstract:

The present invention provides methods for rapidly determining the function of nucleic acid sequences by transfecting the same into a host organism to effect expression. Phenotypic and biochemical changes produced thereby are then analyzed to ascertain the function of the nucleic acids which have been transfected into the host organism. The invention also provides methods for silencing endogenous genes by transfecting hosts with nucleic acid sequences to effect expression of the same. The present invention also provides methods for selecting desired functions of RNAs and proteins by the use of virus vectors to express libraries of nucleic acid sequence variants. Moreover, the present invention provides methods for inhibiting an endogenous protease of a plant host.

US Patent:

20120058310, Mar 8, 2012

Filed:

May 3, 2010

Appl. No.:

13/318603

Inventors:

Dale L. Ehnes - Cotati CA, US
Alan B. Campbell - Santa Rosa CA, US
Mark E. Gardiner - Santa Rosa CA, US
Robert Lee Erwin - Hudson WI, US

International Classification:

B23B 1/00
B32B 3/30

US Classification:

428169, 82 111

Abstract:

A method for cutting a pattern in a work piece (), wherein the pattern includes adjacent features () separated by a pitch spacing P. The method includes providing a cutting tool assembly () having a first tool shank with a first cutting tip () to create a first feature () in the work piece () and a second tool shank with a second cutting tip () to create a second feature () in the work piece (), wherein a distance Y between the first cutting tip and the second cutting tip is equal to nP, and wherein n is an odd integer greater than 1. The work piece is rotated (C) with respect to the cutting tool assembly (), and the cutting tool is advanced along a lateral direction (B) with respect to the rotating work piece (), wherein the cutting tool () is advanced along the lateral direction a distance of 2P for each rotation of the work piece ().