Robert Francis Farrell

US Patent:

61945994, Feb 27, 2001

Filed:

Apr 8, 1997

Appl. No.:

8/825792

Inventors:

Joseph A. Miller - San Jose CA
Robert P. Farrell - San Francisco CA

Assignee:

Catalytica, Inc. - Mountain View CA

International Classification:

C07C25330
C07C 284
C07D20730
C07D30734
C07D33304

US Classification:

558411

Abstract:

The present invention provides a process for preparing biaryl compounds comprising reacting an arylzinc reagent with an arylchloride in the presence of a nickel catalyst or a palladium catalyst. The present invention specifically provides a process for the preparation of 2-(4'-methylphenyl)benzonitrile comprising reacting a 4-methylphenylzinc reagent with 2-chlorobenzonitrile in the presence of a nickel catalyst or a palladium catalyst.

US Patent:

60914262, Jul 18, 2000

Filed:

Jul 3, 1997

Appl. No.:

8/887415

Inventors:

Jerrold V. Hauck - Fremont CA
Randy R. Dunton - Phoenix AZ
Robert L. Farrell - Hillsborough NJ

Assignee:

Intel Corporation - Santa Clara CA

International Classification:

G09G 500

US Classification:

345439

Abstract:

A scaling circuit residing on a single silicon substrate includes a buffer for storing a plurality of partially scaled data. A multiplier is provided for multiplying a weight signal with each of a plurality of input data to produce a plurality of weighted data. An adder is coupled to (1) the multiplier and (2) the buffer for adding each of the weighted data to one of the partially scaled data to produce a plurality of scaled data. When a first one of the scaled data is produced by the adder, the first one of the scaled data can remain in the buffer until displaced by a new data to be scaled such that the scaling circuit is directly coupled to an external bus without requiring any external buffering memory coupled in between. A method for scaling a block of data and transferring the scaled data to the bus is also described.

US Patent:

20180319773, Nov 8, 2018

Filed:

Jul 12, 2018

Appl. No.:

16/033632

Inventors:

- Thousand Oaks CA, US
Xiaoqi CHEN - Palo Alto CA, US
Yinhong CHEN - Hayward CA, US
Alan C. CHENG - San Francisco CA, US
Richard V. CONNORS - Mesa AZ, US
Jeffrey DEIGNAN - San Francisco CA, US
Paul John DRANSFIELD - Arlington MA, US
Xiaohui DU - Belmont CA, US
Zice FU - Foster City CA, US
Julie Anne HEATH - Chico CA, US
Daniel B. HORNE - Natick MA, US
Jonathan HOUZE - Cambridge MA, US
Matthew R. KALLER - Ventura CA, US
Aarif Yusuf KHAKOO - Woodside CA, US
David John KOPECKY - Washington DC, US
Su-Jen LAI - Boston MA, US
Zhihua MA - Lexington MA, US
Lawrence R. MCGEE - Pacifica CA, US
Julio C. MEDINA - San Carlos CA, US
Jeffrey T. MIHALIC - San Francisco CA, US
Nobuko NISHIMURA - West Hills CA, US
Steven H. OLSON - Millbrae CA, US
Vatee PATTAROPONG - Bedford MA, US
Gayathri SWAMINATH - Brisbane CA, US
Xiaodong WANG - Johns Creek GA, US
Kevin YANG - San Gabriel CA, US
Wen-Chen YEH - Belmont CA, US
Mikkel V. DEBENEDETTO - Waltham MA, US
Robert P. FARRELL - Thousand Oaks CA, US
Simon J. HEDLEY - Thousand Oaks CA, US
Ted C. JUDD - Granada Hills CA, US
Frank KAYSER - San Francisco CA, US

Assignee:

AMGEN INC. - Thousand Oaks CA

International Classification:

C07D 401/14
C07D 401/12
A61K 31/437
C07D 417/14
A61K 45/06
C07B 57/00
C07B 59/00
C07D 211/54
C07D 213/71
C07D 213/82
C07D 239/26
C07D 239/30
C07D 241/12
C07D 241/24
C07D 249/08
C07D 471/04
C07D 413/14
C07D 413/04
C07D 401/04
C07D 213/61
C07D 239/34
C07D 241/18
C07F 7/08
C07D 295/16
C07C 311/13
A61K 31/695
A61K 31/4439
A61K 31/444
A61K 31/497
A61K 31/501
A61K 31/506
A61K 31/513
C07D 405/14

Abstract:

Compounds of Formula I and Formula II, pharmaceutically acceptable salt thereof, stereoisomers of any of the foregoing, or mixtures thereof are agonists of the APJ Receptor and have use in treating cardiovascular and other conditions. Compounds of Formula I and Formula II have the following structures:where the definitions of the variables are provided herein.

US Patent:

20170042871, Feb 16, 2017

Filed:

Oct 19, 2016

Appl. No.:

15/297487

Inventors:

- Thousand Oaks CA, US
Xiaoqi CHEN - Palo Alto CA, US
Yinhong CHEN - Hayward CA, US
Alan C. CHENG - San Francisco CA, US
Richard V. CONNORS - Mesa AZ, US
Jeffrey DEIGNAN - San Francisco CA, US
Paul John DRANSFIELD - Arlington MA, US
Xiaohui DU - Belmont CA, US
Zice FU - Foster City CA, US
Julie Anne HEATH - Chico CA, US
Daniel B. HORNE - Natick MA, US
Jonathan HOUZE - Cambridge MA, US
Matthew R. KALLER - Ventura CA, US
Aarif Yusuf KHAKOO - Woodside CA, US
David John KOPECKY - Studio City CA, US
Su-Jen LAI - Boston MA, US
Zhihua MA - Lexington MA, US
Lawrence R. MCGEE - Pacifica CA, US
Julio C. MEDINA - San Carlos CA, US
Jeffrey T. MIHALIC - San Francisco CA, US
Nobuko NISHIMURA - West Hills CA, US
Steven H. OLSON - Millbrae CA, US
Vatee PATTAROPONG - Bedford MA, US
Gayathri SWAMINATH - Brisbane CA, US
Xiaodong WANG - Johns Creek GA, US
Kevin YANG - San Gabriel CA, US
Wen-Chen YEH - Belmont CA, US
Mikkel V. DEBENEDETTO - Waltham MA, US
Robert P. FARRELL - Thousand Oaks CA, US
Simon J. HEDLEY - Thousand Oaks CA, US
Ted C. JUDD - Granada Hills CA, US
Frank KAYSER - San Francisco CA, US

International Classification:

A61K 31/4439
A61K 31/501
A61K 31/444
A61K 31/506
A61K 31/497

Abstract:

Compounds of Formula I and Formula II, pharmaceutically acceptable salt thereof, stereoisomers of any of the foregoing, or mixtures thereof are agonists of the APJ Receptor and have use in treating cardiovascular and other conditions. Compounds of Formula I and Formula II have the following structures:where the definitions of the variables are provided herein.

US Patent:

20170042872, Feb 16, 2017

Filed:

Oct 19, 2016

Appl. No.:

15/297940

Inventors:

- Thousand Oaks CA, US
Xiaoqi CHEN - Palo Alto CA, US
Yinhong CHEN - Hayward CA, US
Alan C. CHENG - San Francisco CA, US
Richard V. CONNORS - Mesa AZ, US
Jeffrey DEIGNAN - San Francisco CA, US
Paul John DRANSFIELD - Arlington MA, US
Xiaohui DU - Belmont CA, US
Zice FU - Foster City CA, US
Julie Anne HEATH - Chico CA, US
Daniel B. HORNE - Natick MA, US
Jonathan HOUZE - Cambridge MA, US
Matthew R. KALLER - Ventura CA, US
Aarif Yusuf KHAKOO - Woodside CA, US
David John KOPECKY - Studio City CA, US
Su-Jen LAI - Boston MA, US
Zhihua Ma - Lexington MA, US
Lawrence R. MCGEE - Pacifica CA, US
Julio C. MEDINA - San Carlos CA, US
Jeffrey T. MIHALIC - San Francisco CA, US
Nobuko NISHIMURA - West Hills CA, US
Steven H. OLSON - Millbrae CA, US
Vatee PATTAROPONG - Bedford MA, US
Gayathri SWAMINATH - Brisbane CA, US
Xiaodong WANG - Johns Creek GA, US
Kevin YANG - San Gabriel CA, US
Wen-Chen YEH - Belmont CA, US
Mikkel V. DEBENEDETTO - Waltham MA, US
Robert P. FARRELL - Thousand Oaks CA, US
Simon J. HEDLEY - Thousand Oaks CA, US
Ted C. Judd - Granada Hills CA, US
Frank KAYSER - San Francisco CA, US

International Classification:

A61K 31/4439
A61K 31/695
A61K 31/501
A61K 31/497
A61K 31/444
A61K 45/06
A61K 31/506

Abstract:

Compounds of Formula I and Formula II, pharmaceutically acceptable salt thereof, stereoisomers of any of the foregoing, or mixtures thereof are agonists of the APJ Receptor and have use in treating cardiovascular and other conditions. Compounds of Formula I and Formula II have the following structures:where the definitions of the variables are provided herein.

US Patent:

20170042897, Feb 16, 2017

Filed:

Oct 20, 2016

Appl. No.:

15/298686

Inventors:

- Thousand Oaks CA, US
Xiaoqi Chen - Palo Alto CA, US
Yinhong Chen - Hayward CA, US
Alan C. Cheng - San Francisco CA, US
Richard V. Connors - Mesa AZ, US
Jeffrey Deignan - San Francisco CA, US
Paul John Dransfield - Arlington VA, US
Xiaohui Du - Belmont CA, US
Zice Fu - Foster City CA, US
Julie Anne Heath - Chico CA, US
Daniel B. Horne - Natick MA, US
Jonathan Houze - Cambridge MA, US
Matthew R. Kaller - Ventura CA, US
Aarif Yusuf Khakoo - Woodside CA, US
David John Kopecky - Studio City CA, US
Su-Jen Lai - Boston MA, US
Zhihua Ma - Lexington MA, US
Lawrence R. McGee - Pacifica CA, US
Julio C. Medina - San Carlos CA, US
Jeffrey T. Mihalic - San Francisco CA, US
Nobuko Nishimura - West Hills CA, US
Steven H. Olson - Millbrae CA, US
Vatee Pattaropong - Bedford MA, US
Gayathri Swaminath - Brisbane CA, US
Xiaodong Wang - Johns Creek GA, US
Kevin Yang - San Gabriel CA, US
Wen-Chen Yeh - Belmont CA, US
Mikkel V. Debenedetto - Waltham MA, US
Robert P. Farrell - Thousand Oaks CA, US
Simon J. Hedley - Thousand Oaks CA, US
Ted C. Judd - Granada Hills CA, US
Frank Kayser - San Francisco CA, US

International Classification:

A61K 31/506
C07D 213/82
A61K 31/497
C07D 241/24
C07D 401/12
A61K 45/06
A61K 31/4439

Abstract:

Compounds of Formula I and Formula II, pharmaceutically acceptable salt thereof, stereoisomers of any of the foregoing, or mixtures thereof are agonists of the APJ Receptor and have use in treating cardiovascular and other conditions. Compounds of Formula I and Formula II have the following structures:where the definitions of the variables are provided herein.

US Patent:

20170044131, Feb 16, 2017

Filed:

Oct 20, 2016

Appl. No.:

15/298434

Inventors:

- Thousand Oaks CA, US
Xiaoqi CHEN - Palo Alto CA, US
Yinhong CHEN - Hayward CA, US
Alan C. CHENG - San Francisco CA, US
Richard V. CONNORS - Mesa AZ, US
Jeffrey DEIGNAN - San Francisco CA, US
Paul John DRANSFIELD - Arlington MA, US
Xiaohui DU - Belmont CA, US
Zice FU - Foster City CA, US
Julie Anne HEATH - Chico CA, US
Daniel B. HORNE - Natick MA, US
Jonathan HOUZE - Cambridge MA, US
Matthew R. KALLER - Ventura CA, US
Aarif Yusuf KHAKOO - Woodside CA, US
David John KOPECKY - Studio City CA, US
Su-Jen LAI - Boston MA, US
Zhihua MA - Lexington MA, US
Lawrence R. MCGEE - Pacifica CA, US
Julio C. MEDINA - San Carlos CA, US
Jeffrey T. MIHALIC - San Francisco CA, US
Nobuko NISHIMURA - West Hills CA, US
Steven H. OLSON - Millbrae CA, US
Vatee PATTAROPONG - Bedford MA, US
Gayathri SWAMINATH - Brisbane CA, US
Xiaodong WANG - Johns Creek GA, US
Kevin YANG - San Gabriel CA, US
Wen-Chen YEH - Belmont CA, US
Mikkel V. DEBENEDETTO - Waltham MA, US
Robert P. FARRELL - Thousand Oaks CA, US
Simon J. HEDLEY - Thousnad Oaks CA, US
Ted C. JUDD - Granada Hills CA, US
Frank KAYSER - San Francisco CA, US

International Classification:

C07D 401/04
A61K 45/06
C07D 401/14
A61K 31/506
C07D 417/14
A61K 31/444
A61K 31/497
A61K 31/513
C07D 471/04
A61K 31/4439
C07D 413/14

Abstract:

Compounds of Formula I and Formula II, pharmaceutically acceptable salt thereof, stereoisomers of any of the foregoing, or mixtures thereof are agonists of the APJ Receptor and have use in treating cardiovascular and other conditions. Compounds of Formula I and Formula II have the following structures:where the definitions of the variables are provided herein.

US Patent:

20170035744, Feb 9, 2017

Filed:

Oct 20, 2016

Appl. No.:

15/298748

Inventors:

- Thousand Oaks CA, US
Xiaoqi CHEN - Palo Alto CA, US
Yinhong CHEN - Hayward CA, US
Alan C. CHENG - San Francisco CA, US
Richard V. CONNORS - Mesa AZ, US
Jeffrey DEIGNAN - San Francisco CA, US
Paul John DRANSFIELD - Arlington MA, US
Xiaohui DU - Belmont CA, US
Zice FU - Foster City CA, US
Julie Anne HEATH - Chico CA, US
Daniel HORNE - Natick MA, US
Jonathan HOUZE - Cambridge MA, US
Matthew R. KALLER - Ventura CA, US
Aarif Yusuf KHAKOO - Woodside CA, US
David John KOPECKY - Studio City CA, US
Su-Jen LAI - Boston MA, US
Zhihua MA - Lexington MA, US
Lawrence R. MCGEE - Pacifica CA, US
Julio C. MEDINA - San Carlos CA, US
Jeffrey T. MIHALIC - San Francisco CA, US
Nobuko NISHIMURA - West Hills CA, US
Steven H. OLSON - Millbrae CA, US
Vatee PATTAROPONG - Bedford MA, US
Gayathri SWAMINATH - Brisbane CA, US
Xiaodong WANG - Johns Creek GA, US
Kevin YANG - San Gabriel CA, US
Wen-Chen YEH - Belmont CA, US
Mikkel V. DEBENEDETTO - Waltham MA, US
Robert P. FARRELL - Thousand Oaks CA, US
Simon J. HEDLEY - Thousand Oaks CA, US
Ted C. JUDD - Granada Hills CA, US
Frank KAYSER - San Francisco CA, US

International Classification:

A61K 31/4439
C07D 239/30
C07D 241/18
C07D 213/61
A61K 31/695
A61K 31/444
A61K 31/497
A61K 31/437
A61K 31/501
A61K 45/06
C07C 311/13
C07D 241/12
C07D 239/34
C07D 295/16
A61K 31/506
C07D 239/26

Abstract:

Compounds of Formula I and Formula II, pharmaceutically acceptable salt thereof, stereoisomers of any of the foregoing, or mixtures thereof are agonists of the APJ Receptor and have use in treating cardiovascular and other conditions. Compounds of Formula I and Formula II have the following structures:where the definitions of the variables are provided herein.