Robert W Fleming

US Patent:

39579883, May 18, 1976

Filed:

Feb 20, 1973

Appl. No.:

5/334075

Inventors:

Robert W. Fleming - Ann Arbor MI
Arthur D. Sill - Greenhills OH

Assignee:

Richardson-Merrell Inc. - Wilton CT

International Classification:

A01N 900

US Classification:

424248

Abstract:

The novel bis-basic ketones of thioxanthene have antiviral activity when administered orally and parenterally. These compounds are represented by the following formula: ##SPC1## Wherein A is a straight or branched alkylene chain having from 1 to about 6 carbon atoms; and each Y is A. the group ##EQU1## wherein R. sup. 1 and R. sup. 2 are individually hydrogen or lower alkyl having from 1 to about 4 carbon atoms; or B. the group ##EQU2## WHEREIN N IS A WHOLE INTEGER OF 4 OR 5, AND R. sup. 3 is hydrogen or lower alkyl having from 1 to about 4 carbon atoms and can be linked to any one of the carbon atoms of the heterocyclic group; or C. the group ##EQU3## wherein X is oxygen or NR. sup. 4, and R. sup. 4 is hydrogen or lower alkyl of from 1 to about 4 carbon atoms; or pharmaceutically acceptable acid addition salts of said base. These new compounds can be prepared by several different methods which are described.

US Patent:

43805485, Apr 19, 1983

Filed:

Aug 27, 1981

Appl. No.:

6/296764

Inventors:

Robert W. Fleming - Ann Arbor MI

Assignee:

Warner-Lambert Company - Morris Plains NJ

International Classification:

A61K 31415
C07D23342

US Classification:

424273R

Abstract:

The invention provides new N-(2,6-dimethylphenyl)-2-methylthio-1-imidazolidinecarboxamides and their pharmaceutically acceptable salts which are useful as anticonvulsant agents. Also provided are methods for preparing the compounds of the invention, pharmaceutical compositions containing said compounds and methods for using said compositions.

US Patent:

39579891, May 18, 1976

Filed:

Feb 20, 1973

Appl. No.:

5/333768

Inventors:

Robert W. Fleming - Ann Arbor MI
Arthur D. Sill - Greenhills OH
Francis W. Sweet - Cincinnati OH

Assignee:

Richardson-Merrell Inc. - Wilton CT

International Classification:

A01N 900

US Classification:

424248

Abstract:

Novel bis-basic ketones of xanthene and xanthen-9-one have antiviral activity when administered orally and parenterally. The compounds are represented by the following formula: ##SPC1## Wherein Z is oxygen or H. sub. 2 ; each A is a straight or branched alkylene chain having from 1 to about 6 carbon atoms; and each Y is A. the group ##EQU1## wherein R. sup. 1 and R. sup. 2 are individually hydrogen, lower alkyl having from 1 to about 6 carbon atoms, cycloalkyl having from 3 to 6 carbon atoms, alkenyl of from 3 to 6 carbon atoms and having the vinyl unsaturation in other than the 1-position of the alkenyl group; or B. the group ##EQU2## WHEREIN N IS A WHOLE INTEGER FROM 4 TO 6, AND R. sup. 3 is hydrogen, lower alkyl of from 1 to about 4 carbon atoms and can be linked to any one of the carbon atoms of the heterocyclic group; or C. the group ##EQU3## wherein X is oxygen or NR. sup. 4, and R. sup.

US Patent:

40311015, Jun 21, 1977

Filed:

Apr 15, 1976

Appl. No.:

5/677094

Inventors:

Robert Willerton Fleming - Ann Arbor MI

Assignee:

Parke, Davis & Company - Detroit MI

International Classification:

C07D21132

US Classification:

26029384

Abstract:

cis-2,6-Dimethyl-. alpha. ,. alpha. -diphenyl-1-piperidinebutanol; and acid-addition salts. The compounds are pharmacological agents, especially antiarrythmic agents. The compounds can be produced by reacting phenyl lithium or phenylmagnesium halide with cis-. gamma. -(2,6-dimethylpiperidino)butyrophenone or a lower alkyl ester of cis-2,6-dimethyl-1-piperidinebutyric acid; by reacting. alpha. -(3-halopropyl)-. alpha. -phenylbenzyl alcohol with cis-2,6-dimethylpiperidine, or by reacting cis-1- (3-lithiopropyl)-2,6-dimethylpiperidine with benzophenone.

US Patent:

41121031, Sep 5, 1978

Filed:

Feb 25, 1977

Appl. No.:

5/772203

Inventors:

Robert Willerton Fleming - Ann Arbor MI

Assignee:

Parke, Davis & Company - Detroit MI

International Classification:

C07D21338

US Classification:

424267

Abstract:

(+,-)-cis-. alpha. [3-(2,6-Dimethyl-1-piperidinyl)propyl]-. alpha. -phenyl-2-py ridinemethanol and acid-addition salts. The compounds are pharmacological agents, especially antiarrhythmic agents. The compounds can be produced by reacting pyridyllithium with cis-. gamma. -(2,6-dimethylpiperidino)butyrophenone, or by reacting cis-1-(3-lithiopropyl)-2,6-dimethylpiperidine with 2-benzoylpyridine. Pharmaceutical compositions comprising (+,-)-cis-. alpha. -[3-(2,6-dimethyl-1-piperidinyl)propyl]-. alpha. -phenyl-2- pyridinemethanol and acid-addition salts thereof and methods for treating cardiac arrhythmia using said pharmaceutical compositions are also disclosed.

US Patent:

20150088516, Mar 26, 2015

Filed:

Dec 1, 2014

Appl. No.:

14/557304

Inventors:

- Burlington MA, US
Raghu Vemula - Wilmington DE, US
Robert Fleming - Lynnfield MA, US

Assignee:

Nuance Communications, Inc. - Burlington MA

International Classification:

G10L 15/18

US Classification:

704251

Abstract:

In some embodiments, the recognition results produced by a speech processing system (which may include two or more recognition results, including a top recognition result and one or more alternative recognition results) based on an analysis of a speech input, are evaluated for indications of potential significant errors. In some embodiments, the recognition results may be evaluated to determine whether a meaning of any of the alternative recognition results differs from a meaning of the top recognition result in a manner that is significant for a domain, such as the medical domain. In some embodiments, words and/or phrases that may be confused by an ASR system may be determined and associated in sets of words and/or phrases. Words and/or phrases that may be determined include those that change a meaning of a phrase or sentence when included in the phrase/sentence.