Robert Leon Foote

US Patent:

6346305, Feb 12, 2002

Filed:

Jun 17, 1998

Appl. No.:

09/098742

Inventors:

J. Michael Ramsey - Knoxville TN
Robert S. Foote - Oak Ridge TN

Assignee:

UT-Battelle, LLC - Oak Ridge TN

International Classification:

B32B 1700

US Classification:

428 341, 428 344, 428333, 428426, 428428, 435 6, 4352872, 4352873

Abstract:

A method of performing a lower temperature bonding technique to bond together two mating pieces of glass includes applying a sodium silicate aqueous solution between the two pieces.

US Patent:

6376181, Apr 23, 2002

Filed:

Dec 14, 1999

Appl. No.:

09/460316

Inventors:

J. Michael Ramsey - Knoxville TN
Robert S. Foote - Oak Ridge TN

Assignee:

UT-Battelle, LLC - Oak Ridge TN

International Classification:

C12Q 168

US Classification:

435 6, 436 94

Abstract:

A method and apparatus for analyzing nucleic acids includes immobilizing nucleic probes at specific sites within a microchannel structure and moving target nucleic acids into proximity to the probes in order to allow hybridization and fluorescence detection of specific target sequences.

US Patent:

6428896, Aug 6, 2002

Filed:

Jun 17, 1998

Appl. No.:

09/098743

Inventors:

J. Michael Ramsey - Knoxville TN
Robert S. Foote - Oak Ridge TN

Assignee:

UT-Battelle, LLC - Oak Ridge TN

International Classification:

B32B 900

US Classification:

428428, 428426, 4283155, 4283159, 427243

Abstract:

A method of performing a lower temperature bonding technique to bond together two mating pieces of glass includes applying a sodium silicate aqueous solution between the two pieces.

US Patent:

6660480, Dec 9, 2003

Filed:

Mar 5, 2002

Appl. No.:

10/090955

Inventors:

J. Michael Ramsey - Knoxville TN
Robert S. Foote - Oak Ridge TN

Assignee:

UT-Battelle, LLC - Oak Ridge TN

International Classification:

C12Q 168

US Classification:

435 6, 4352852, 4352872, 436 94

Abstract:

A method and apparatus for analyzing nucleic acids includes immobilizing nucleic probes at specific sites within a microchannel structure and moving target nucleic acids into proximity to the probes in order to allow hybridization and fluorescence detection of specific target sequences.

US Patent:

6685809, Feb 3, 2004

Filed:

Feb 4, 1999

Appl. No.:

09/244914

Inventors:

Stephen C. Jacobson - Knoxville TN
J. Michael Ramsey - Knoxville TN
Christopher T. Culbertson - Oak Ridge TN
William B. Whitten - Lancing TN
Robert S. Foote - Oak Ridge TN

Assignee:

UT-Battelle, LLC - Wilmington DE

International Classification:

G01N 27447

US Classification:

204450, 204451, 204518, 204520, 204600, 204601, 204627, 204630, 422100

Abstract:

A microfabricated device employing a bridging membrane and methods for electrokinetic transport of a liquid phase biological or chemical material using the same are described. The bridging membrane is deployed in or adjacent to a microchannel and permits either ionic current flow or the transport of gas species, while inhibiting the bulk flow of material. The use of bridging membranes in accordance with this invention is applicable to a variety of processes, including electrokinetically induced pressure flow in a region of a microchannel that is not influenced by an electric field, sample concentration enhancement and injection, as well as improving the analysis of materials where it is desired to eliminate electrophoretic bias. Other applications of the bridging membranes according to this invention include the separation of species from a sample material, valving of fluids in a microchannel network, mixing of different materials in a microchannel, and the pumping of fluids.

US Patent:

7179591, Feb 20, 2007

Filed:

May 16, 2001

Appl. No.:

09/859028

Inventors:

Robert S. Foote - Oak Ridge TN, US

International Classification:

C12Q 1/68

US Classification:

435 6, 435 71, 536 253, 530333

Abstract:

A method and apparatus are provided for performing light-directed reactions in spatially addressable channels within a plurality of channels. One aspect of the invention employs photoactivatable reagents in solutions disposed into spatially addressable flow streams to control the parallel synthesis of molecules immobilized within the channels. The reagents may be photoactivated within a subset of channels at the site of immobilized substrate molecules or at a light-addressable site upstream from the substrate molecules. The method and apparatus of the invention find particularly utility in the synthesis of biopolymer arrays, e. g. , oligonucleotides, peptides and carbohydrates, and in the combinatorial synthesis of small molecule arrays for drug discovery.

US Patent:

7550410, Jun 23, 2009

Filed:

Nov 14, 2006

Appl. No.:

11/559549

Inventors:

Robert S. Foote - Oak Ridge TN, US

International Classification:

C40B 50/00

US Classification:

506 23, 506 7, 506 33, 435 6, 435 71, 536 253, 530333

Abstract:

A method and apparatus are provided for performing light-directed reactions in spatially addressable channels within a plurality of channels. One aspect of the invention employs photoactivatable reagents in solutions disposed into spatially addressable flow streams to control the parallel synthesis of molecules immobilized within the channels. The reagents may be photoactivated within a subset of channels at the site of immobilized substrate molecules or at a light-addressable site upstream from the substrate molecules. The method and apparatus of the invention find particularly utility in the synthesis of biopolymer arrays, e. g. , oligonucleotides, peptides and carbohydrates, and in the combinatorial synthesis of small molecule arrays for drug discovery.

US Patent:

7909973, Mar 22, 2011

Filed:

Oct 19, 2007

Appl. No.:

11/875027

Inventors:

Stephen C. Jacobson - Knoxville TN, US
J. Michael Ramsey - Knoxville TN, US
Christopher T. Culbertson - Oak Ridge TN, US
William B. Whitten - Lancing TN, US
Robert S. Foote - Oak Ridge TN, US

Assignee:

UT-Battelle, LLC - Wilmington DE

International Classification:

G01N 27/447
G01N 27/453

US Classification:

204450, 204451, 204601

Abstract:

A microfabricated device employing a bridging membrane and methods for electrokinetic transport of a liquid phase biological or chemical material using the same are described. The bridging membrane is deployed in or adjacent to a microchannel and permits either ionic current flow or the transport of gas species, while inhibiting the bulk flow of material. The use of bridging membranes in accordance with this invention is applicable to a variety of processes, including electrokinetically induced pressure flow in a region of a microchannel that is not influenced by an electric field, sample concentration enhancement and injection, as well as improving the analysis of materials where it is desired to eliminate electrophoretic bias. Other applications of the bridging membranes according to this invention include the separation of species from a sample material, valving of fluids in a microchannel network, mixing of different materials in a microchannel, and the pumping of fluids.