Robert P Freeman

US Patent:

55366368, Jul 16, 1996

Filed:

Feb 28, 1994

Appl. No.:

8/202389

Inventors:

Robert M. Freeman - Boston MA
Jorge Plutzky - Boston MA
Benjamin G. Neel - Wayland MA
Robert D. Rosenberg - Brookline MA

Assignee:

Beth Israel Hospital - Boston MA
Massachusetts Institute of Technology - Cambridge MA

International Classification:

C07H 2164
C12P 1934
C12Q 168

US Classification:

435 6

Abstract:

The present invention relates to the isolation of genes encoding novel protein tyrosine phosphatases (PTPs) having SH2 domains, the nucleic acid sequences isolated, and the encoded phosphatases. The invention further relates to methods of altering tyrosine phosphatase activities encoded by the novel phosphatases. By altering (i. e. , increasing or decreasing) tyrosine phosphatase activity, one can alter megakaryocyte cell function, and thereby alter platelet production. Alteration of the genes is associated with neoplastic disease.

US Patent:

54720222, Dec 5, 1995

Filed:

Nov 2, 1993

Appl. No.:

8/146313

Inventors:

Peter Michel - Burgdorf, CH
Robert S. Freeman - Weston MA
James Q. Oeswein - El Granada CA

Assignee:

Genentech, Inc. - South San Francisco CA

International Classification:

B65B 104
B65B 304

US Classification:

141 1

Abstract:

An injection pen apparatus (30) for medicament injection including a medicament cartridge assembly (31) formed to receive and contain a medicament therein. A holding sleeve (34) is provided which is dimensioned to receive the medicament cartridge assembly (31) therein which mates with a solution transfer device (35) including an axially movable displacement rod (36). The injection pen apparatus (30) further includes a coupling mechanism (37) removably coupling the solution transfer device (35) to both a plunger (32) slidably movable in the cartridge (33) and to the holding sleeve (34). A sleeve mounting assembly (40) of the coupling mechanism (37) removably mounts the coupling mechanism to the holding sleeve (34). A locking device (41) is included which is formed and dimensioned to require joining of the displacement rod (36) relative the sleeve mounting assembly (40) after uncoupling of the rod from the plunger (32) and before uncoupling of a remainder of the solution transfer device (35) from the holding sleeve (34).