Robert K Freeman

US Patent:

55366368, Jul 16, 1996

Filed:

Feb 28, 1994

Appl. No.:

8/202389

Inventors:

Robert M. Freeman - Boston MA
Jorge Plutzky - Boston MA
Benjamin G. Neel - Wayland MA
Robert D. Rosenberg - Brookline MA

Assignee:

Beth Israel Hospital - Boston MA
Massachusetts Institute of Technology - Cambridge MA

International Classification:

C07H 2164
C12P 1934
C12Q 168

US Classification:

435 6

Abstract:

The present invention relates to the isolation of genes encoding novel protein tyrosine phosphatases (PTPs) having SH2 domains, the nucleic acid sequences isolated, and the encoded phosphatases. The invention further relates to methods of altering tyrosine phosphatase activities encoded by the novel phosphatases. By altering (i. e. , increasing or decreasing) tyrosine phosphatase activity, one can alter megakaryocyte cell function, and thereby alter platelet production. Alteration of the genes is associated with neoplastic disease.

US Patent:

54720222, Dec 5, 1995

Filed:

Nov 2, 1993

Appl. No.:

8/146313

Inventors:

Peter Michel - Burgdorf, CH
Robert S. Freeman - Weston MA
James Q. Oeswein - El Granada CA

Assignee:

Genentech, Inc. - South San Francisco CA

International Classification:

B65B 104
B65B 304

US Classification:

141 1

Abstract:

An injection pen apparatus (30) for medicament injection including a medicament cartridge assembly (31) formed to receive and contain a medicament therein. A holding sleeve (34) is provided which is dimensioned to receive the medicament cartridge assembly (31) therein which mates with a solution transfer device (35) including an axially movable displacement rod (36). The injection pen apparatus (30) further includes a coupling mechanism (37) removably coupling the solution transfer device (35) to both a plunger (32) slidably movable in the cartridge (33) and to the holding sleeve (34). A sleeve mounting assembly (40) of the coupling mechanism (37) removably mounts the coupling mechanism to the holding sleeve (34). A locking device (41) is included which is formed and dimensioned to require joining of the displacement rod (36) relative the sleeve mounting assembly (40) after uncoupling of the rod from the plunger (32) and before uncoupling of a remainder of the solution transfer device (35) from the holding sleeve (34).

US Patent:

49807862, Dec 25, 1990

Filed:

Nov 14, 1988

Appl. No.:

7/270717

Inventors:

William O'Sullivan - Milpitas CA
Robert Freeman - Erie CO
Harold T. Wright - San Carlos CA

Assignee:

Maxtor Corporation - San Jose CA

International Classification:

G11B 3314

US Classification:

360 9703

Abstract:

A thermally independent dedicated servo disk drive where the temperature is kept within an acceptable range and temperature gradients that can cause differential thermal expansion are eliminated to minimize off tracking due to differential thermal expansion of thermally sensitive components. A novel isolated "box within a box" architecture is utilized to provide a thermal buffer to external temperature gradients and an inner HDA support structure is coupled to an outer housing with thermally insulative isolators which prevent the conductive transfer of heat from external sources where the outer housing and isolators create a thermal buffer to shield the inner HDA support structure from external heat sources. In addition, certain heat generating components not integrated into the symmetrical thermal "box within a box" design are isolated where possible. Thus, a thermally symmetrical environment is provided in the area of thermally sensitive components that could otherwise degrade tracking during temperature transients.

US Patent:

50579541, Oct 15, 1991

Filed:

Feb 13, 1989

Appl. No.:

7/310292

Inventors:

William O'Sullivan - Milpitas CA
Robert D. Freeman - Erie CO

Assignee:

Maxtor Corporation - San Jose CA

International Classification:

G11B 554

US Classification:

360105

Abstract:

A head loading mechanism for a disk drive. When power to the disk drive is disconnected, an actuating spring is released. Movement of the spring causes a plunger to contact a bracket on the actuator arm, moving the actuator arm over a parking zone. Further movement of the spring causes blades to lift read/write heads mounted on the actuator arm away from disk surfaces. When power is restored, a motor compresses the spring and returns the plunger and the blades to their original positions.