Robert S Grossman

US Patent:

20200289476, Sep 17, 2020

Filed:

Nov 28, 2018

Appl. No.:

16/767706

Inventors:

- Houston TX, US
Robert G. Grossman - Houston TX, US

Assignee:

University of Houston System - Houston TX
The Methodist Hospital Research Institute - Houston TX

International Classification:

A61K 31/428
A61K 47/34
A61K 47/10
A61K 9/00

Abstract:

Embodiments of the present disclosure pertain to compositions that include a liquid formulation comprising a molecule selected from the group consisting of riluzole, a derivative of riluzole, an analog of riluzole, a pharmaceutical equivalent of riluzole, a benzothiazole-based molecule, combinations thereof, and salts thereof. The liquid formulations may also include a solubilizing agent. Additional embodiments of the present disclosure pertain to methods of treating a condition or disease in a subject by administering to the subject a composition of the present disclosure. The condition or disease to be treated may include spinal cord injury, and the administration may occur by parenteral administration. In some embodiments, the administered molecule may have an absorption half-life of less than 1.5 hours, an elimination half-life of more than 10 hours, and a bioavailability of more than 65%. Additional embodiments of the present disclosure pertain to methods of making the compositions.

Address:

9539 Vogue Ln, Houston, TX 77080

Phone:

8322564152

VIN:

2MEFM74V97X620692

Make:

MERCURY

Model:

GRAND MARQUIS

Year:

2007

Address:

4103 Ruskin St, Houston, TX 77005

VIN:

4T1BE46K87U657122

Make:

TOYOTA

Model:

CAMRY

Year:

2007