Li Chen - Westfield NJ Robert William Guthrie - Saddle Brook NJ Jefferson Wright Tilley - North Caldwell NJ Kenneth Gregory Hull - Cambridge MA
Assignee:
Hoffmann-La Roche Inc. - Nutley NJ
International Classification:
A61K 314166
US Classification:
514341, 514386, 5462744, 5483225, 5483255
Abstract:
Compounds of the formula: are disclosed which have activity as inhibitors of binding between VCAM-1 and cells expressing VLA-4. Such compounds are useful for treating diseases whose symptoms and/or damage are related to the binding of VCAM-1 to cells expressing VLA-4.
Aromatic dehydroamino acids are disclosed that are active as LFA-1 arnagonists This activity enables these compounds to prevent inflammation which is a consequence of T cell activation and accordingly reduce or eliminate inflammatory skin disease psoriasis.
A compound of formula Id and pharmaceutically acceptable salts and esters thereof, wherein the substituent designations are as provided in the specification. Compounds of the invention are useful for treating reperfusion injury.
Compounds of the formula: are disclosed which have activity as inhibitors of binding between VCAM-1 and cells expressing VLA-4. Such compounds are useful for treating diseases whose symptoms and/or damage are related to the binding of VCAM-1 to cells expressing VLA-4.
Compounds of the formula: are disclosed which have activity as inhibitors of binding between VCAM-1 and cells expressing VLA-4. Such compounds are useful for treating diseases whose symptoms and/or damage are related to the binding of VCAM-1 to cells expressing VLA-4.
Isbn (Books And Publications)
Neonatal Screening for Inborn Errors of Metabolism
2007 to 2000 Executive Director of Computing and Information Technology ServicesPFIZER INC St. Louis, MO 2004 to 2007 Director Research InformaticsTRI-COM CONSULTING GROUP Groton, CT 2002 to 2004 Administrative and EngineeringHOFFMANN - LA ROCHE
1998 to 2002 DirectorHOFFMANN - LA ROCHE Nutley, NJ 1993 to 2002 Director, Research Informatics
Education:
DUKE UNIVERSITY Durham, NC 2002 MBAST PETERS UNIVERSITY Jersey City, NJ BS in Mathematics and Computer Science
2007 to 2000 Executive Director of Computing and Information Technology ServicesPFIZER INC St. Louis, MO 2004 to 2007 Director Research InformaticsTRI-COM CONSULTING GROUP Groton, CT 2002 to 2004 Administrative and EngineeringHOFFMANN - LA ROCHE
1998 to 2002 DirectorHOFFMANN - LA ROCHE Nutley, NJ 1993 to 2002 Director, Research Informatics
Education:
DUKE UNIVERSITY Durham, NC 2002 MBAST PETERS UNIVERSITY Jersey City, NJ BS in Mathematics and Computer Science
At a Cumberland Farms that has been mentioned again and again as a place where some mouths need to be rinsed with soap, Robert Guthrie, 62, said the law crosses the fine line of independence. But he said he had voted for it just the same, because it was a town where the youths didnt have a lot o
Date: Jun 13, 2012
Category: U.S.
Source: Google
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