Robert A Heintz

US Patent:

6417387, Jul 9, 2002

Filed:

Mar 5, 2001

Appl. No.:

09/798255

Inventors:

Michael L. Vazquez - Gurnee IL
Richard A. Mueller - Glencoe IL
John J. Talley - Brentwood MO
Daniel P. Getman - Chesterfield MO
Gary A. DeCrescenzo - St. Peters MO
John N. Freskos - Clayton MO
Deborah E. Bertenshaw - Brentwood MO
Robert M. Heintz - Ballwin MO

Assignee:

G.D. Searle Co. - Chicago IL

International Classification:

C07C30300

US Classification:

560 13

Abstract:

- and -amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.

US Patent:

6455581, Sep 24, 2002

Filed:

May 25, 1995

Appl. No.:

08/451090

Inventors:

Michael L. Vazquez - Gurnee IL
Richard A. Mueller - Glencoe IL
John J. Talley - St. Louis MO
Daniel P Getman - Chesterfield MO
Gary A. DeCrescenzo - St. Peters MO
John N. Freskos - Clayton MO
Robert M. Heintz - Ballwin MO
Deborah E. Bertenshaw - Brentwood MO

Assignee:

G.D. Searle Co. - Chicago IL

International Classification:

A61K 3127

US Classification:

514487, 514513, 514605, 514365, 558240, 560 16, 564 74, 564 99, 548204

Abstract:

- and -amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.

US Patent:

6476027, Nov 5, 2002

Filed:

Dec 6, 1999

Appl. No.:

09/254531

Inventors:

Clara I. Villamil - Glenview IL
John N. Freskos - Clayton MO
Brent V. Mischke - Defiance MO
Patrick B. Mullins - St. Louis MO
Robert M. Heintz - Ballwin MO
Daniel P. Getman - Chesterfield MO
Joseph J. McDonald - Ballwin MO
Gary A. DeCrescenzo - St. Charles MO
Thomas E. Barta - Evanston IL
Daniel P. Becker - Glenview IL

Assignee:

Monsanto Company - St. Louis MO

International Classification:

A61K 3116

US Classification:

5142378, 514330, 514331, 514357, 514428, 514486, 514575, 544159, 546225, 546226, 546233, 546340, 548568, 560 13, 562621, 562623

Abstract:

An N-hydroxy sulfonyl butanamide compound that inter alia inhibits matrix metalloprotease activity is disclosed as are a treatment process that comprises administering a contemplated N-hydroxy sulfonyl butanamide compound in a MMP enzyme-inhibiting effective amount to a host having a condition associated with pathological matrix metalloprotease activity.

US Patent:

6500832, Dec 31, 2002

Filed:

Mar 14, 2000

Appl. No.:

09/525161

Inventors:

Michael L. Vazquez - Gurnee IL
Richard A. Mueller - Glencoe IL
John J. Talley - St. Louis MO
Daniel P Getman - Chesterfield MO
Gary A. DeCrescenzo - St. Peters MO
John N. Freskos - Clayton MO
Robert M. Heintz - Ballwin MO
Deborah E. Bertenshaw - Brentwood MO

Assignee:

G. D. Searle Co. - Skokie IL

International Classification:

A61K 31505

US Classification:

514256, 514277, 514365, 544335, 546323, 546337, 548204, 560 13

Abstract:

- and -amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.

US Patent:

6646010, Nov 11, 2003

Filed:

May 30, 2002

Appl. No.:

10/157019

Inventors:

Michael L. Vazquez - Gurnee IL
Richard A. Mueller - Glencoe IL
John J. Talley - Brentwood MO
Daniel P. Getman - Chesterfield MO
Gary A. DeCrescenzo - St. Peters MO
John N. Freskos - Clayton MO
Deborah E. Bertenshaw - Brentwood MO
Robert M. Heintz - Ballwin MO

Assignee:

G. D. Searle Co. - Chicago IL

International Classification:

A61K 3118

US Classification:

514605, 514351, 5142521, 544336, 546300, 564 92

Abstract:

- and -amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.

US Patent:

6846954, Jan 25, 2005

Filed:

Jul 22, 2002

Appl. No.:

10/199481

Inventors:

Michael L Vazquez - Gurnee IL, US
Richard A. Mueller - Glencoe IL, US
John J. Talley - St. Louis MO, US
Daniel P Getman - Chesterfield MO, US
Gary A. DeCrescenzo - St. Peters MO, US
John N. Freskos - Clayton MO, US
Robert M. Heintz - Ballwin MO, US
Deborah E. Bertenshaw - Brentwood MO, US

Assignee:

G. D. Searle & Co. - Chicago IL

International Classification:

C07C31119

US Classification:

564 86

Abstract:

α- and β-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.

US Patent:

6924286, Aug 2, 2005

Filed:

Aug 4, 2003

Appl. No.:

10/633376

Inventors:

Michael L. Vazquez - Gurnee IL, US
Richard A. Mueller - Glencoe IL, US
John J. Talley - Brentwood MO, US
Daniel P. Getman - Chesterfield MO, US
Gary A. DeCrescenzo - St. Peters MO, US
John N. Freskos - Clayton MO, US
Deborah E. Bertenshaw - Brentwood MO, US
Robert M. Heintz - Ballwin MO, US

Assignee:

G. D. Searle & Co. - Chicago IL

International Classification:

A61K031/535
A61K031/44
C07D211/70
C07D265/30
C07C303/00

US Classification:

5142378, 514357, 514601, 514604, 514605, 544159, 546334, 546337, 564 80, 564 92, 564 99

Abstract:

α- and β-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.

US Patent:

7115618, Oct 3, 2006

Filed:

Mar 30, 2004

Appl. No.:

10/812343

Inventors:

Michael J. Vazquez - Gurnee IL, US
Richard A. Mueller - Glencoe IL, US
John J. Talley - St. Louis MO, US
Daniel P. Getman - Chesterfield MO, US
Gary A. DeCrescenzo - St. Peters MO, US
John N. Freskos - Clayton MO, US
Robert M. Heintz - Ballwin MO, US
Deborah E. Bertenshaw - Brentwood MO, US

Assignee:

G.D. Searle & Co. - Chicago IL

International Classification:

A61K 31/36
C07D 317/50

US Classification:

514277, 514408, 546314, 546316, 546335, 546336, 548400

Abstract:

α- and β-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.