Robert F Huebner

US Patent:

7635486, Dec 22, 2009

Filed:

Jan 14, 1999

Appl. No.:

09/600057

Inventors:

Edwin W. Ades - Atlanta GA, US
George M. Carlone - Stone Mountain GA, US
Barun K. De - Snellville GA, US
Jacquelyn S. Sampson - College Park GA, US
Robert C. Huebner - Stroudsburg PA, US

Assignee:

The United States of America as represented by the Department of Health and Human Services - Washington DC

International Classification:

A61K 39/02
A61K 45/00
A61K 39/09

US Classification:

4242001, 424 91, 424 92, 4241841, 4241921, 4242341, 4242441, 4242781, 435243, 4352521, 4352534

Abstract:

The present invention relates to recombinant lipidated PsaA proteins and recombinant constructs from which such lipidated PsaA proteins may be expressed. The invention relates further to lipidated PsaA proteins in which lipidation is effected by the use of a heterologous leader sequence derived from the ospA gene of which leader sequence is joined in translational reading frame with the psaA structural gene. The invention also provides methods of preparation of lipidated PsaA proteins and use of such proteins in immunological compositions. Also provided are vaccines comprising immunogenic lipidated PsaA proteins and methods of use of such vaccines in the prevention and treatment of infection.

US Patent:

7960535, Jun 14, 2011

Filed:

Nov 16, 2009

Appl. No.:

12/619357

Inventors:

Edwin W. Ades - Atlanta GA, US
George M. Carlone - Stone Mountain GA, US
Barun K. De - Snellville GA, US
Jacquelyn S. Sampson - College Park GA, US
Robert C. Huebner - Stroudsburg PA, US

Assignee:

The United States of America as represented by the Department of Health and Human Services - Washington DC

International Classification:

C07H 21/02
C07H 21/04
A61K 49/00

US Classification:

536 237, 536 231, 424 91, 424 92, 4241841, 4241851, 4241921, 4242001

Abstract:

The present invention relates to recombinant lipidated PsaA proteins and recombinant constructs from which such lipidated PsaA proteins may be expressed. The invention relates further to lipidated PsaA proteins in which lipidation is effected by the use of a heterologous leader sequence derived from the ospA gene of , which leader sequence is joined in translational reading frame with the psaA structural gene. The invention also provides methods of preparation of lipidated PsaA proteins and use of such proteins in immunological compositions. Also provided are vaccines comprising immunogenic lipidated PsaA proteins and methods of use of such vaccines in the prevention and treatment of infection.

US Patent:

52792056, Jan 18, 1994

Filed:

Dec 15, 1992

Appl. No.:

7/990969

Inventors:

Guy C. Carlson - Minooka IL
William K. Engel - Peoria IL
Robert J. Huebner - Peoria IL
Donald H. Sherman - Morton IL

Assignee:

Caterpillar Inc. - Peoria IL

International Classification:

F01B 1300

US Classification:

91485

Abstract:

Axial piston fluid translating units commonly experience undesirable shaft deflections and barrel tilting during operation. A fluid translating unit includes a barrel plate interposed the end of a barrel and a porting surface defined within a housing thereof. The barrel plate is axially spaced from an end of the barrel and is in face sealing engagement with the porting surface. The barrel plate defines a plurality of fluid ports, each communicating between one of a plurality of barrel cylinder bores and the porting surface. In one aspect a plurality of counterbores are provided in the barrel in surrounding relation to the fluid ports. A plurality of seal rings having a sealing end defining an annular seal face of a predetermined width for face sealing engagement with the barrel plate. The seal rings are each disposed in one of the counterbores in circumferential sealing relation of a predetermined length which is no greater than the width of the sealing face. A plurality of annular springs are disposed in the counterbores for urging the seal rings into sealing engagement with the other of the barrel and the barrel plate.