Robert M Katz

Address:

40 Pheasant Chase, West Hartford, CT 06117

VIN:

19UUA765X7A014701

Make:

ACURA

Model:

TL

Year:

2007

Address:

576 Farmington Ave, Hartford, CT 06105

VIN:

WDDNG86XX7A130768

Make:

MERCEDES-BENZ

Model:

S-CLASS

Year:

2007

US Patent:

60050047, Dec 21, 1999

Filed:

Jun 7, 1995

Appl. No.:

8/487693

Inventors:

Robert Katz - Gaithersburg MD
Maria Tomoaia-Cotisel - Rockville MD

Assignee:

Molecular / Structural Biotechnologies, Inc. - Bethesda MD

International Classification:

A01N 3706
A01N 3702
A61K 3122
A61K 3123

US Classification:

514549

Abstract:

The present invention describes site-specific biomolecular complexes comprising a therapeutic, prophylactic and diagnostic agent, called also biologically active molecule and an omega-3 fatty acid and derivatives thereof. The complexes are further covalently bonded with cationic carriers and permeabilizer peptides for delivery across the blood-brain barrier and with targeting moieties for uptake by target brain cells. Said complexes are particularly useful for delivery of a biologically active agent to the glial tissue of the brain as well as to the cortical, cholinergic and adrenergic neurons. The preferred therapeutic complexes or conjugates comprise an omega-3 fatty acid such as alpha-linolenic acid, eicosapentaenoic acid or docosahexaenoic acid and derivatives thereof.

US Patent:

57166145, Feb 10, 1998

Filed:

Aug 5, 1994

Appl. No.:

8/286327

Inventors:

Robert Katz - Gaithersburg MD
Maria Tomoaia-Cotisel - Rockville MD

Assignee:

Molecular/Structural BioTechnologies, Inc. - Bethesda MD

International Classification:

A61K 3854
A61K 39395
A61K 4500
A61K 3800

US Classification:

424 943

Abstract:

A method is disclosed for delivering biologically active agents to a mammalian brain by administering a complex of the biologically active agent with a polycationic carrier coupled to 2-20 eicosapentaenoic acid or docosahexaenoic acid moieties and additional eicosapentaenoic acid or docosahexaenoic acid moieties. The polycationic carrier is poly-lysine, poly-arginine or poly-ornithine of 5-50 amino acid residues. The addition of a targeting moiety selected from tetanus toxin C fragrant,. alpha. -bungarotoxin and nerve growth factor to the complex facilitates delivery of the biologically active agent to glial tissue, or to cortical, cholinergic and adrenergic neurons.

US Patent:

59256699, Jul 20, 1999

Filed:

Jul 17, 1995

Appl. No.:

8/503326

Inventors:

Robert Katz - Gaithersburg MD

Assignee:

Molecular/Structural Bio Technologies, Inc. - Bethesda MD

International Classification:

A61K 31335
A61K 3170
A61K 3120
A61K 3324

US Classification:

514449

Abstract:

The invention provides new carrier compositions containing a triglyceridic oil rich in DHA and anti-neoplastic drugs and a DHA-containing phospholipid.