Robert F Kirkpatrick

US Patent:

6576427, Jun 10, 2003

Filed:

May 2, 1997

Appl. No.:

08/850348

Inventors:

Robert B Kirkpatrick - King of Prussia PA
Martin Rosenberg - Royersford PA

Assignee:

SmithKline Beecham Corporation - Philadelphia PA

International Classification:

G01N 3353

US Classification:

435 71, 435331, 5303873, 5303875, 5303879, 5303881, 53038815, 5303891, 436501

Abstract:

Nucleic acid sequences for HC gp-39L is provided. Methods of detecting altered expression of tissue remodeling proteins and diagnosing tissue remodeling disorders are also provided.

US Patent:

7067280, Jun 27, 2006

Filed:

Feb 27, 2003

Appl. No.:

10/373802

Inventors:

Robert Kirkpatrick - King of Prussia PA, US
Martin Rosenberg - Royersford PA, US

Assignee:

SmithKline Beecham Corp. - King of Prussia PA

International Classification:

C12N 15/00

US Classification:

435 691, 536 231, 435 231, 435325, 4353201

Abstract:

Nucleic acid sequences for HC gp-39L are provided. Methods of detecting altered expression of tissue remodeling proteins and diagnosing tissue remodeling disorders are also provided.

US Patent:

7186528, Mar 6, 2007

Filed:

Jun 11, 2001

Appl. No.:

10/311491

Inventors:

Robert B. Kirkpatrick - King of Prussia PA, US
Allan R. Shatzman - King of Prussia PA, US

Assignee:

SmithKline Beecham Corporation - Philadelphia PA

International Classification:

C12P 21/04

US Classification:

435 6952, 435325, 530350, 530351

Abstract:

A method for producing a physiologically active polypeptide, comprising contacting a precursor polypeptide with an activating enzyme, or co-expressing the polypeptide with an activating protease.

US Patent:

7311902, Dec 25, 2007

Filed:

Apr 14, 2004

Appl. No.:

10/823964

Inventors:

Narendra Bam - King of Prussia PA, US
Jacob Bongers - King of Prussia PA, US
Robert B. Kirkpatrick - King of Prussia PA, US
Cheryl A. Janson - Hinsdale IL, US
Zdenka Jonak - King of Prussia PA, US
Xianyang Qiu - Mystic CT, US
Ping Yeh - King of Prussia PA, US
Kyung Johanson - King of Prussia PA, US

Assignee:

SmithKline Beecham Corporation - Philadelphia PA

International Classification:

C07K 14/54
A61K 38/20

US Classification:

424 852, 530351

Abstract:

Human interleukin-18 (IL-18) polypeptides and substitution mutants thereof were conjugated to water-soluble polymers at specific sites on the human IL-18 protein. These conjugated human IL-18 and substitution mutants thereof retain biological activity. These conjugated cytokines demonstrate enhanced and unexpected biological properties when compared to the corresponding unconjugated cytokines.

US Patent:

7442526, Oct 28, 2008

Filed:

Apr 11, 2006

Appl. No.:

11/402187

Inventors:

Kyung O. Johanson - King of Prussia PA, US
Robert B. Kirkpatrick - King of Prussia PA, US
Allan R. Shatzman - King of Prussia PA, US
Yen Sen Ho - Berwyn PA, US
Patrick McDevitt - King of Prussia PA, US

Assignee:

SmithKline Beecham Corporation - Philadelphia PA

International Classification:

C12P 21/02

US Classification:

435 697, 435 6952, 530351

Abstract:

The present invention provides a method for producing physiologically active human Interleukin-18 (“IL-18”).

US Patent:

7736639, Jun 15, 2010

Filed:

Dec 21, 2007

Appl. No.:

11/962811

Inventors:

Narendra Bam - King of Prussia PA, US
Jacob Bongers - King of Prussia PA, US
Robert B. Kirkpatrick - King of Prussia PA, US
Cheryl A. Janson - Hinsdale IL, US
Zdenka Jonak - King of Prussia PA, US
Xianyang Qiu - Mystic CT, US
Ping Yeh - King of Prussia PA, US
Kyung Johanson - King of Prussia PA, US

Assignee:

GlaxoSmithKline LLC - Philadelphia PA

International Classification:

A61K 45/00
A61K 38/00

US Classification:

424 852, 514 12

Abstract:

Methods of treating cancer in patients in need thereof with human interleukin-18 (IL-18) polypeptides and substitution mutants thereof that are conjugated to water-soluble polymers at specific sites on the human IL-18 protein are disclosed.

US Patent:

60959363, Aug 1, 2000

Filed:

Aug 8, 1997

Appl. No.:

8/907600

Inventors:

Andrew M Kirkpatrick - Media PA
Robert C. Kirkpatrick - Newark DE
Theodore J. Kirkpatrick - Wynnewood PA

International Classification:

A63B 6900

US Classification:

473450

Abstract:

A shooting aid for basketball players designed to keep the elbow of the shooting arm in towards the center line of the body during shooting. The shooting aid comprises a sleeve adapted to fit around the shooting arm of the basketball player; a clip adapted to be secured to clothing worn by the basketball player; and an elastic cord with two ends having one end attached to the sleeve and the other end attached to the clip, wherein the cord is of sufficient length to restrain the position of the player's shooting arm when the player shoots a basketball. In another embodiment, a belt adapted to be worn by the player can be used instead of the clip.

US Patent:

57260613, Mar 10, 1998

Filed:

Oct 8, 1996

Appl. No.:

8/727210

Inventors:

David Robbins - King of Prussia PA
Robert B. Kirkpatrick - King of Prussia PA
Stephen D. Holmes - Great Chishill, GB2

Assignee:

SmithKline Beechum Corporation - King of Prussia PA

International Classification:

G01N 3348
G01N 3353
G01N 33537
G01N 33543

US Classification:

436 64

Abstract:

Methods of screening for colorectal cancer by measuring levels of HC gp-39 are provided. Methods of monitoring patients with colorectal cancer are also provided. In addition, kits for detection of HC gp-39 useful in screening for and monitoring of colorectal cancer in a patient are provided.