Robert L Lagace

US Patent:

6389428, May 14, 2002

Filed:

Apr 11, 2001

Appl. No.:

09/797653

Inventors:

Philippe E. Rigault - Palo Alto CA
Anne L. Curtis - Pacifica CA
Richard D. Goold - Belmont CA
David A. Hadley - Palo Alto CA
Harold H. Hibbert - Fremont CA
Tod M. Klingler - San Carlos CA
Robert E. Lagace - San Francisco CA
Laura L. Stuve - Los Gatos CA
Michael G. Walker - Sunnyvale CA
Michael P. Wood - San Francisco CA

Assignee:

Incyte Pharmaceuticals, Inc. - Palo Alto CA

International Classification:

G06F 1730

US Classification:

7071041, 707 6, 707100, 702 19, 435 6

Abstract:

A computer system stores biomolecular data in a database in a memory. The biomolecular database has a set of entities. Each entity stores attributes for a plurality of entries. At least one attribute is stored in an array. Data associated with an entry is stored at a location in the array. An entity offset designates the location of the data in the array. The same entity offset value is used to access data associated with a particular entry for all attributes within the entity.

US Patent:

6632636, Oct 14, 2003

Filed:

Jun 16, 2000

Appl. No.:

09/596002

Inventors:

Robert E. Lagace - Belmont CA
Chandra Patterson - Menlo Park CA
Kim L. Berg - Palo Alto CA

Assignee:

Elitra Pharmaceuticals Inc. - San Diego CA

International Classification:

C12P 2106

US Classification:

435 691, 435 701, 435 711, 435189, 4352523, 43525411, 4353201, 435325, 435440, 536 232, 536 2432

Abstract:

The present invention provides the genomic sequences of a library of purified nucleic acid molecules, or their complements, comprising the genome of. The invention also provides the identification of open reading frames contained within the nucleic acid molecules of the library. The present invention further provides for the use of the nucleic acid molecules, their complements or fragments, and proteins or portions thereof for identifying ligands and useful diagnostic and therapeutic compositions. In addition the invention provides for vectors, host cells and methods for producing proteins or portions thereof.

US Patent:

8409806, Apr 2, 2013

Filed:

Nov 24, 2010

Appl. No.:

12/954551

Inventors:

Robert Green - Cupertino CA, US
Julio Mulero - Sunnyvale CA, US
Lori Hennessy - San Mateo CA, US
Robert Lagace - Oakland CA, US
Chien-Wei Chang - Belmont CA, US

Assignee:

Life Technologies Corporation - Carlsbad CA

International Classification:

C12Q 1/68
C12P 19/34

US Classification:

435 612, 435 912

Abstract:

Disclosed are rare short tandem repeat (STR) alleles within the D10S1248 and D12S391 loci in humans. Provided are representative allelic ladders for each locus, methods and assays using these alleles and kits containing allelic ladders comprising these alleles for accurate genotyping and identification of a wide range of individuals.

US Patent:

8637655, Jan 28, 2014

Filed:

Aug 13, 2010

Appl. No.:

12/856530

Inventors:

Julio Mulero - Sunnyvale CA, US
Robert Green - Cupertino CA, US
Robert Lagace - Oakland CA, US
Lori Hennessy - San Mateo CA, US

Assignee:

Life Technologies Corporation - Carlsbad CA

International Classification:

C07H 21/04
C12P 19/34

US Classification:

536 2433, 435 912

Abstract:

Disclosed are methods for gender determination in the intron 1 region of the amelogenin locus and a newly discovered single nucleotide polymorphism (SNP) within the X chromosome of the amelogenin locus which can cause allelic dropout. Also disclosed are kits useful in gender determination.

US Patent:

20040067554, Apr 8, 2004

Filed:

Sep 26, 2003

Appl. No.:

10/672787

Inventors:

Robert Lagace - Belmont CA, US
Chandra Patterson - Menlo Park CA, US
Kim Berg - Palo Alto CA, US

International Classification:

C12P021/06

US Classification:

435/069100

Abstract:

The present invention provides the genomic sequences of a library of purified, polynucleotides, or their complements, comprising the genome of . The invention also provides the identification of open reading frames contained within the polynucleotides of the library. The present invention further provides for the use of the polynucleotides, their complements or fragments, and proteins or portions thereof for identifying ligands and useful diagnostic and therapeutic compositions. In addition the invention provides for vectors, host cell sand methods for producing proteins or portions thereof.

US Patent:

20110183857, Jul 28, 2011

Filed:

Oct 15, 2010

Appl. No.:

12/905916

Inventors:

Julio Mulero - Sunnyvale CA, US
Michael Malicdem - Santa Clara CA, US
Robert Lagace - Oakland CA, US

Assignee:

LIFE TECHNOLOGIES CORPORATION - Carlsbad CA

International Classification:

C40B 30/00
C12Q 1/68
C07H 21/04

US Classification:

506 7, 435 611, 536 231

Abstract:

Disclosed are methods for human identification utilizing newly discovered single nucleotide polymorphisms (SNPs) within CODIS loci which can cause allelic dropout. Also disclosed are kits useful in human identification.

US Patent:

20120070832, Mar 22, 2012

Filed:

Sep 21, 2011

Appl. No.:

13/239335

Inventors:

Robert GREEN - Cupertino CA, US
Dennis Wang - Dublin CA, US
Julio Mulero - Sunnyvale CA, US
Robert Lagace - Oakland CA, US

Assignee:

LIFE TECHNOLOGIES CORPORATION - Carlsbad CA

International Classification:

C12P 19/34
C12Q 1/68
C07H 21/04

US Classification:

435 611, 536 231, 435 912, 536 2433

Abstract:

Disclosed are primer set compositions, methods and kits for human identification using the highly complex sequence locus, SE33 (ACTBP2) in single and multiplex PCR reactions. Additionally, disclosed are three newly discovered single nucleotide polymorphisms (SNPs) within the SE33 locus that can cause discordance seen as mobility shift or allelic dropout. Also disclosed are kits useful in human identification.

US Patent:

62231863, Apr 24, 2001

Filed:

Oct 20, 1998

Appl. No.:

9/175738

Inventors:

Philippe E. Rigault - Palo Alto CA
Anne L. Curtis - Pacifica CA
Richard D. Goold - Belmont CA
David A. Hadley - Palo Alto CA
Harold H. Hibbert - Fremont CA
Tod M. Klingler - San Carlos CA
Robert E. Lagace - San Francisco CA
Laura L. Stuve - Los Gatos CA
Michael G. Walker - Sunnyvale CA
Michael P. Wood - San Francisco CA

Assignee:

Incyte Pharmaceuticals, Inc. - Palo Alto CA

International Classification:

G06F 1730

US Classification:

707104

Abstract:

A computer system stores biomolecular data in a database in a memory. The biomolecular database has a set of entities. Each entity stores attributes for a plurality of entries. At least one attribute is stored in an array. Data associated with an entry is stored at a location in the array. An entity offset designates the location of the data in the array. The same entity offset value is used to access data associated with a particular entry for all attributes within the entity.