Robert B Levin

US Patent:

20030187059, Oct 2, 2003

Filed:

Feb 24, 2003

Appl. No.:

10/373625

Inventors:

Robert Levin - Albany NY, US
Martha Hass - Wynantskill NY, US

International Classification:

A61K031/382
C 07D 4 9/02
A61K031/355
A61K031/385

US Classification:

514/440000, 514/458000, 549/035000, 549/408000

Abstract:

Disclosed are methods for treating obstructive and ischemic bladder diseases which include administering a compound which includes a cyclic or acyclic disulfide covalently bonded to a lipid-soluble antioxidant or which include administering a reduced sulfhydryl derivative thereof. Also disclosed are compounds that include a benzopyran moiety which is directly or indirectly covalently bonded to a cyclic or acyclic disulfide, as well as reduced sulfhydryl derivatives of such compounds. Methods for making such compounds and reduced sulfhydryl derivatives using tocopherol and lipoic acid starting materials are also disclosed, as are methods for inhibiting oxidative and/or free radical damage in a subject's cells, nerve membranes, sarcoplasmic reticula, mitochondrial membranes, and/or muscle plasma membranes and methods for treating and/or preventing obstructive and ischemic bladder diseases, conditions involving hypoxia, ischemia, and/or reoxygenation injury.