Robert L Levin

US Patent:

6432365, Aug 13, 2002

Filed:

Apr 14, 2000

Appl. No.:

09/549283

Inventors:

Robert Levin - San Diego CA
Rob Neeper - Lakeside CA
John Bridwell - San Diego CA

Assignee:

Discovery Partners International, Inc.

International Classification:

B01L 300

US Classification:

422100, 422 681, 422 99, 422102, 436180, 141 31, 141234, 141236, 7386401, 7386451, 7386491

Abstract:

An automated sample-on-solid-support processing system includes a treatment solution supply subsystem which feeds solvent to a dispenser to dispense a measured amount of treatment solution to each well of a multi-well plate. The dispenser measures the solution within a fill container having a plurality of reservoir wells corresponding to the number of wells in the multi-well plate. The fill container is contained within a reservoir chamber that is filled with an excess of solution. Each reservoir well is surrounded by a plurality of bores which drains excess solution from the top of the fill container so that a precise amount of solution is left in the reservoir wells when solution is drained out of the reservoir chamber. Gas pressure is introduced into the reservoir chamber to force the solution out of the reservoir well through a bundle of tubes, with one tube per well, and into the wells of the multi-well plate.

US Patent:

6808935, Oct 26, 2004

Filed:

Jan 28, 2002

Appl. No.:

10/058380

Inventors:

Robert Levin - San Diego CA
Rob Neeper - Lakeside CA
John Bridwell - San Diego CA

Assignee:

Discovery Partners International, Inc. - San Diego CA

International Classification:

B01L 302

US Classification:

436180, 422100

Abstract:

An automated sample-on-solid-support processing system includes a treatment solution supply subsystem which feeds solvent to a dispenser to dispense a measured amount of treatment solution to each well of a multi-well plate. The dispenser measures the solution within a fill container having a plurality of reservoir wells corresponding to the number of wells in the multi-well plate. The fill container is contained within a reservoir chamber that is filled with an excess of solution. Each reservoir well is surrounded by a plurality of bores which drains excess solution from the top of the fill container so that a precise amount of solution is left in the reservoir wells when solution is drained out of the reservoir chamber. Gas pressure is introduced into the reservoir chamber to force the solution out of the reservoir well through a bundle of tubes, with one tube per well, and into the wells of the multi-well plate.

US Patent:

7575116, Aug 18, 2009

Filed:

Jun 16, 2003

Appl. No.:

10/461545

Inventors:

Robert M. Levin - Fairfax VA, US

International Classification:

B65D 85/00

US Classification:

206320

Abstract:

A protective cover is designed to be removably placed over the keyboard tray and mouse pad of a bracket system including an articulating bracket having a proximal end designed to be affixed to the undersurface of a desk top and a distal end to which the keyboard tray is mounted. The protective cover consists of a padded bag having an inner chamber sized to receive the keyboard tray and mouse pad, and a cover designed to close its access opening which consists of two flaps spaced by a recessed portion, with the recessed portion provided to allow the flaps to fold over to either side of the bracket. Each of the flaps has a releasable fastener designed to fasten the flaps in a closed configuration. Another releasable fastener is provided on the bracket and the bag so that the fastener halves can be releasably attached together to hold the bracket system in a folded configuration making it easy to transport.

US Patent:

7596251, Sep 29, 2009

Filed:

Jan 30, 2004

Appl. No.:

10/769462

Inventors:

Rhett L. Affleck - Poway CA, US
Mike Bodnar - San Diego CA, US
Robert K. Levin - San Diego CA, US
John E. Lillig - Ramona CA, US
Robert K. Neeper - Lakeside CA, US

Assignee:

Nexus Biosystems, Inc. - Poway CA

International Classification:

G06K 9/00
A61B 19/02
A61C 19/02
B01L 9/02
A47B 88/06

US Classification:

382128, 312209, 312294

Abstract:

An automated biological sample analysis system and method for use in incubating and analyzing multiple samples for protein crystallization. A temperature controlled cabinet houses sample storage, sample transport, and sample imaging systems. The operation of the system is automated and can be controlled by software, which can be reconfigured remotely. An array of storage shelves includes multiple shelf columns arranged around a core. Multiple banks of removable shelves arranged as magazines are accessed through a door on the cabinet. Each shelf stores a multi-well plate and different sizes can be stored in different shelves. The core houses a sample transport system that includes a multi-axis robot that rotates about a vertical axis to access the shelves in the shelf array. The transport system retrieves and replaces the multi-well plates in the shelves and can move plates from the shelves to an imaging system where each sample can be automatically imaged.

US Patent:

7832449, Nov 16, 2010

Filed:

Jun 30, 2006

Appl. No.:

11/428334

Inventors:

Robert Kenjiro Levin - San Diego CA, US
Sakae Tasaki - Ishioka, JP

International Classification:

B60C 25/132
B60C 25/12

US Classification:

157 117, 157 147

Abstract:

Apparatus and methods are described for mounting and dismounting tires. Apparatus typically comprises a pressing assembly positionable relative to a fixed wheel rim such that the pressing assembly controls force distribution across selected portions of a tire causing a tire bead to be eased onto the wheel rim. The apparatus typically includes an axis of rotation perpendicular to the wheel rim axis and wherein the axis of rotation is positionable in a plane that includes the wheel rim axis. The wheel rim can be fixed to a base assembly and handles allow positioning and transmittal of force to the pressing assembly. A bead breaking assembly for deflating an inflated tire may be provided. Methods of operating these and other such apparatus are described.

US Patent:

20040218804, Nov 4, 2004

Filed:

Jan 30, 2004

Appl. No.:

10/769150

Inventors:

Rhett Affleck - Poway CA, US
Robert Levin - San Diego CA, US
John Lillig - Ramona CA, US
Robert Neeper - Ramona CA, US
William Ewing - Encinitas CA, US
Duane DeSieno - La Jolla CA, US
Eric Hansen - San Luis Obispo CA, US
Mike Bodnar - San Diego CA, US

International Classification:

G06K009/00

US Classification:

382/141000

Abstract:

An image analysis system and related methods for automation of the monitoring of samples to determine crystal growth. Samples are imaged from time to time using a set of imaging parameters. The resulting images are evaluated to determine the contents of the samples. If the evaluation of the image indicates the presence of crystals, the sample may be re-imaged using a different set of imaging parameters, and the resulting image analyzed to determine its contents. The sample may also be evaluated by generating multiple images of a sample using various sets of imaging parameters, identifying pixels that depict regions of interest in a plurality of images, merging the pixels from each region of interest into a composite image and analyzing the composite image. An image of a sample can also be evaluated by classifying the pixels of the image based on the contents of the sample that they depict, color-coding the pixels using the classifications, and displaying the colored image for analysis.

US Patent:

20040253742, Dec 16, 2004

Filed:

Jan 30, 2004

Appl. No.:

10/769461

Inventors:

Rhett Affleck - Poway CA, US
Robert Levin - San Diego CA, US
John Lillig - Ramona CA, US
Robert Neeper - Ramona CA, US

International Classification:

G01N021/03

US Classification:

436/165000

Abstract:

An imaging system for automation of sample monitoring includes an image capture device that cooperates with a lens assembly for imaging the samples. A translator positions the lens assembly and/or a sample plate mount for acquisition of the images. Some embodiments of the system include a light source configured to provide low temperature, flash illumination of a sample plate.

US Patent:

20120133756, May 31, 2012

Filed:

Nov 23, 2011

Appl. No.:

13/304084

Inventors:

Robert Levin - San Diego CA, US
Brian K. Rasnow - Newburry Park CA, US
Mel Schehlein - Las Vegas NV, US
Chris Shumate - Carlsbad CA, US
Walter D. Niles - La Jolla CA, US

International Classification:

H04N 7/18

US Classification:

348 79, 348E07085

Abstract:

The present invention provides a compact, inexpensive fluorescence microscope capable of high-resolution imaging with high light throughput suitable for use in both laboratory and field environments, and methods of use. A simple and inexpensive fluorescence microscope allows health care workers to perform various medical assays at the point of care instead of having to collect and transport biological samples to distant labs, and subsequently return the results to the patient. The microscope of the present invention is also useful for educational use and field use, and other uses as well.