Robert J London

US Patent:

6706528, Mar 16, 2004

Filed:

Mar 23, 2001

Appl. No.:

09/816638

Inventors:

Robert E. London - Chapel Hill NC
Pieter Otten - Escondido CA
Louis A. Levy - Chapel Hill NC

Assignee:

The United States of America as represented by the Department of Health and Human Services - Washington DC

International Classification:

G01N 2164

US Classification:

436 79, 436172

Abstract:

The present invention generally relates to analytical elements and methods for the selective determination of magnesium. In particular, the present invention is further directed to carboxy-quinolizine suitable for use as magnesium indicators, and more particularly, to 4-oxo-4H-quinolizine-3-carboxylic acid derivatives for use as novel fluorescent magnesium indicators.

US Patent:

56399065, Jun 17, 1997

Filed:

Oct 11, 1994

Appl. No.:

8/320986

Inventors:

Robert E. London - Chapel Hill NC
Louis A. Levy - Chapel Hill NC
Chung K. Rhee - Durham NC

Assignee:

The United States of America as represented by the Department of Health
and Human Services - Washington DC

International Classification:

C07C 6976
C07C22900
C07C21100

US Classification:

560 62

Abstract:

This invention relates to compositions and methods useful for measuring pH generally, and intracellular pH specifically, and, more particularly, to a new class of fluorescent and fluorinated (NMR sensitive) aromatic compounds having excitation emission wavelengths in the ultraviolet or or visible portions of the electromagnetic spectrum, useful as pH indicators, as well as fluorine containing analogs useful in NMR spectroscopic determinations.

US Patent:

55169112, May 14, 1996

Filed:

Dec 30, 1993

Appl. No.:

8/175590

Inventors:

Robert E. London - Chapel Hill NC
Louis A. Levy - Chapel Hill NC
Elizabeth Murphy - Durham NC

Assignee:

The United States of America as represented by the Department of Health
and Human Services - Washington DC

International Classification:

C07D26334
C07C20506
C07C22940

US Classification:

548236

Abstract:

A new class of calcium-specific, NMR-active and/or fluorescent indicators having a high dissociation constant is described. Methods of determining intracellular calcium ion concentration using. sup. 19 F NMR spectroscopy or optical methods are also provided.