Robert F Mccaffrey

US Patent:

50229966, Jun 11, 1991

Filed:

Apr 30, 1990

Appl. No.:

7/516400

Inventors:

Robert R. McCaffrey - Milford MA
Daniel G. Cummings - Idaho Falls ID

Assignee:

The United States of America as represented by the United States
Department of Energy - Washington DC

International Classification:

B01D 614

US Classification:

210654

Abstract:

A method is provided for separating halogenated hydrocarbons from a fluid feedstream. The fluid feedstream is flowed across a first surface of a polyphosphazene semipermeable membrane. At least one halogenated hydrocarbon from the fluid feedstream permeates through the polyphosphazene semipermeable membrane to a second opposed surface of the semipermeable membrane. Then the permeated polar hydrocarbon is removed from the second opposed surface of the polyphosphazene semipermeable membrane. Outstanding and unexpected separation selectivities on the order of 10,000 were obtained for methylene chloride when a methylene chloride in water feedstream was flowed across the polyphosphazene semipermeable membrane in the invented method.

US Patent:

56016948, Feb 11, 1997

Filed:

Jul 27, 1995

Appl. No.:

8/508276

Inventors:

Thomas C. Maley - Medway MA
Paul A. D'Orazio - Mendon MA
Bonnie C. Dalzell - Sherborn MA
Peter G. Edelman - Franklin MA
James E. Flaherty - Attleboro MA
Richard W. Mason - Millis MA
Robert R. McCaffrey - Franklin MA

Assignee:

Ciba Corning Diagnostics Corp. - Medfield MA

International Classification:

G01N 2726

US Classification:

204415

Abstract:

A solid shale, multi-use electrochemical sensor having an electrically nonconductive substrate, a working electrode, and a semi-permeable membrane covering the working electrode. The working electrode includes an electrically conductive material adhered to a portion of the substrate. A first portion of the conductive material is covered with an electrically insulating dielectric coating, and a second portion of the conductive material is covered with an active layer. The active layer includes a catalytically active quantity of an enzyme carried by platinized carbon powder particles, which are distributed throughout the active layer. A sensor package for incorporating a sensor is provided.

US Patent:

57118680, Jan 27, 1998

Filed:

Sep 15, 1995

Appl. No.:

8/508275

Inventors:

Thomas C. Maley - Medway MA
Paul A. D'Orazio - Mendon MA
Bonnie C. Dalzell - Sherborn MA
Peter G. Edelman - Franklin MA
James E. Flaherty - Attleboro MA
Richard W. Mason - Millis MA
Robert R. McCaffrey - Franklin MA

Assignee:

Chiron Diagnostics Corporatiion - E. Walpole

International Classification:

G01N 2726

US Classification:

2057825

Abstract:

A solid state, multi-use electrochemical sensor having an electrically nonconductive substrate, a working electrode, and a semi-permeable membrane covering the working electrode. The working electrode includes an electrically conductive material adhered to a portion of the substrate. A first portion of the conductive material is covered with an electrically insulating dielectric coating, and a second portion of the conductive material is covered with an active layer. The active layer includes a catalytically active quantity of an enzyme carried by platinized carbon powder particles, which are distributed throughout the active layer. A sensor package for incorporating a sensor is provided.

US Patent:

55736475, Nov 12, 1996

Filed:

Sep 15, 1995

Appl. No.:

8/508270

Inventors:

Thomas C. Maley - Medway MA
Mark W. Boden - Millbury MA
Paul A. D'Orazio - Mendon MA
Bonnie C. Dalzell - Sherborn MA
Peter G. Edelman - Franklin MA
James E. Flaherty - Attleboro MA
Robert B. Green - Hopkinton MA
Steven C. Lepke - Danvers MA
Richard W. Mason - Millis MA
Robert R. McCaffrey - Franklin MA
John A. Zalenski - Mendon MA

Assignee:

Ciba Corning Diagnostics Corp. - Medfield MA

International Classification:

G01N 2726

US Classification:

204406

Abstract:

A solid state, multi-use electrochemical sensor having an electrically nonconductive substrate, a working electrode, and a semi-permeable membrane covering the working electrode. The working electrode includes an electrically conductive material adhered to a portion of the substrate. A first portion of the conductive material is covered with an electrically insulating dielectric coating, and a second portion of the conductive material is covered with an active layer. The active layer includes a catalytically active quantity of an enzyme carried by platinized carbon powder particles, which are distributed throughout the active layer. A sensor package for incorporating a sensor is provided.

US Patent:

57075026, Jan 13, 1998

Filed:

Jul 12, 1996

Appl. No.:

8/680050

Inventors:

Robert McCaffrey - Franklin MA
Katarina Tkacik - Concord MA
Brian Holman - Medfield MA
James Flaherty - Attleboro MA
Josef Brown - Salem NH
Peter Edelman - Franklin MA

Assignee:

Chiron Diagnostics Corporation - E. Walpole MA

International Classification:

G01N 2726

US Classification:

204403

Abstract:

A sensor for measuring a concentration of an analyte in a solution. The sensor comprises a substrate layer, an electrode layer and an immobilized enzyme layer. The sensor further includes an enzyme/polymer layer and/or a hydrophobic layer. The enzyme/polymer layer includes an enzyme disposed within a polymer matrix. The hydrophobic layer is formed from a material that is more hydrophobic than the immobilized enzyme layer material. In certain embodiments, the sensor includes the enzyme/polymer layer and the hydrophobic layer disposed between the enzyme/polymer layer and the immobilized enzyme layer such that the enzyme/polymer layer is disposed along the hydrophobic layer within an area above the immobilized enzyme layer.

US Patent:

56679831, Sep 16, 1997

Filed:

Oct 24, 1994

Appl. No.:

8/327856

Inventors:

Allison L. Abel - Randolph MA
Paul A. D'Orazio - Mendon MA
Bonnie C. Dalzell - Sherborn MA
Robert R. McCaffrey - Franklin MA
Laura S. Uretsky - Milford MA

Assignee:

Chiron Diagnostics Corporation - Walpole MA

International Classification:

C12Q 154
C12Q 100
C12Q 126
C12Q 148

US Classification:

435 14

Abstract:

It has been found that imidazole and related buffers enhance the activity of certain preservatives, for example either (1) a mixture of 5-chloro-2-methyl-4-isothiazolin-3-one and 2-methyl-4-isothiazolin-3-one or (2) 5-bromo-5-nitro-1,3-dioxane, that are used in clinical diagnostic reagents. It has also been found that these buffers and certain surfactants, such as BRIJ 700 and related hydrophilic surfactants, enhance the precision and accuracy of enzyme biosensors.

US Patent:

55296769, Jun 25, 1996

Filed:

Sep 15, 1995

Appl. No.:

8/508269

Inventors:

Thomas C. Maley - Medway MA
Mark W. Boden - Millbury MA
Paul A. D'Orazio - Mendon MA
Bonnie C. Dalzell - Sherborn MA
Peter G. Edelman - Franklin MA
James E. Flaherty - Attleboro MA
Robert B. Green - Hopkinton MA
Steven C. Lepke - Danvers MA
Richard W. Mason - Millis MA
Robert R. McCaffrey - Franklin MA
John A. Zalenski - Mendon MA

Assignee:

Ciba Corning Diagnostics Corp. - Medfield MA

International Classification:

G01N 2726

US Classification:

204409

Abstract:

A solid state, multi-use electrochemical sensor having an electrically nonconductive substrate, a working electrode, and a semi-permeable membrane covering the working electrode. The working electrode includes an electrically conductive material adhered to a portion of the substrate. A first portion of the conductive material is covered with an electrically insulating dielectric coating, and a second portion of the conductive material is covered with an active layer. The active layer includes a catalytically active quantity of an enzyme carried by platinized carbon powder particles, which are distributed throughout the active layer. A sensor package for incorporating a sensor is provided.

US Patent:

56963149, Dec 9, 1997

Filed:

Jul 12, 1996

Appl. No.:

8/679089

Inventors:

Robert McCaffrey - Franklin MA
Bonnie Dalzell - Sherborn MA
Katarina Tkacik - Concord MA
Susan Holbert - Holliston MA
Mark Boden - Millbury MA
James Flaherty - Attleboro MA
Michael Flanagan - Needham MA
Josef Brown - Salem NH
Kimiya Takeshita - Sanda, JP
Peter Edelman - Franklin MA

Assignee:

Chiron Diagnostics Corporation - E. Walpole MA

International Classification:

G01N 2726
G01N 33535
G01N 3366
H01L 2978

US Classification:

73 5301

Abstract:

An electrochemical sensor is designed for use in detecting a concentration of an analyte in a sample solution. The sensor to have a longer useful lifetime, improved stability and improved response time for single or multiple use applications. In one aspect, some of these goals are achieved by providing the multilayer enzyme electrode membrane having both nonporous and microporous layers. The microporous layer is formed from a polymer binder, a polymer powder, a surfactant and a mineral powder. In another aspect, certain of these goals are achieved by the use of a layer comprised of an enzyme disposed within a polymer matrix. In certain embodiments, the multilayer enzyme electrode membrane includes an outermost layer which is capable of dissolving in the sample solution such that the interface between the multilayer enzyme electrode membrane and the sample solution is continually renewed. The sensor provides an electrical current output proportional to the reagent chemical interaction of the analyte with an immobilized enzyme layer during exposure of the sensor in such solution.