Robert R Nagle

US Patent:

6756019, Jun 29, 2004

Filed:

Apr 6, 2000

Appl. No.:

09/544711

Inventors:

Robert S. Dubrow - San Carlos CA
Colin B. Kennedy - Mill Valley CA
Robert Nagle - Mountain View CA
David Chazan - Palo Alto CA
Ernest C. W. Lee - Palo Alto CA
Khushroo Gandhi - Sunnyvale CA
Calvin Y. H. Chow - Portola Valley CA

Assignee:

Caliper Technologies Corp. - Mountain View CA

International Classification:

B01L 300

US Classification:

422102, 422 681, 422 99, 422100, 422103, 436174, 436179, 436180

Abstract:

The present invention provides microfluidic devices that comprise a body structure comprising at least a first microscale channel network disposed therein. The body structure has a plurality of ports disposed in the body structure, where each port is in fluid communication with one or more channels in the first channel network. The devices also include a cover layer comprising a plurality of apertures disposed through the cover layer. The cover layer is mated with the body structure whereby each of the apertures is aligned with a separate one of the plurality of ports. Rings are optionally disposed between the cover layer and the body structure and circumferentially around pairs of aligned apertures and ports. The devices also optionally include conductive coatings and membranes. The invention additionally provides methods of controlling the delivery of a composition of material into a microfluidic device.

US Patent:

20020009392, Jan 24, 2002

Filed:

Mar 26, 2001

Appl. No.:

09/818266

Inventors:

Jeffrey Wolk - Half Moon Bay CA, US
J. Parce - Palo Alto CA, US
Robert Nagle - Mountain View CA, US
Colin Kennedy - Greenbrae CA, US
Syed Husain - Fremont CA, US
Advit Bhatt - Union City CA, US
Garrett Unno - San Jose CA, US

International Classification:

B01L003/02
G01N001/14

US Classification:

422/063000, 436/180000, 422/067000, 422/100000, 422/104000, 204/453000, 204/604000

Abstract:

Methods for reducing fluid carryover by microfluidic devices including capillary element and/or fluid motion. Capillary elements coated with hydrophobic or hydrophilic coatings to resist fluid carryover are also provided. Microfluidic device handling systems are additionally included.

US Patent:

20020127149, Sep 12, 2002

Filed:

May 1, 2001

Appl. No.:

09/846694

Inventors:

Robert Dubrow - San Carlos CA, US
Colin Kennedy - Greenbrae CA, US
Robert Nagle - Mountain View CA, US

International Classification:

B01L003/00

US Classification:

422/102000, 422/068100, 422/099000, 422/100000, 422/103000, 422/104000, 436/174000, 436/179000, 436/180000, 073/863000, 073/863010, 073/863710

Abstract:

The present invention provides microfluidic devices that comprise a body structure comprising at least a first microscale channel network disposed therein. The body structure has a plurality of ports disposed in the body structure, where each port is in fluid communication with one or more channels in the first channel network. The devices also include a cover layer comprising a plurality of apertures disposed through the cover layer. The cover layer is mated with the body structure whereby each of the apertures is aligned with a separate one of the plurality of ports.

US Patent:

D2770644, Jan 8, 1985

Filed:

Oct 28, 1982

Appl. No.:

6/437316

Inventors:

Robert R. Nagle - Gibson City IL

US Classification:

D 6467

US Patent:

54787505, Dec 26, 1995

Filed:

Aug 18, 1994

Appl. No.:

8/292558

Inventors:

Daniel M. Bernstein - San Mateo CA
Paul J. Lingane - Palo Alto CA
Robert Nagle - Mountain View CA
Vladimir E. Ostoich - Los Altos CA

Assignee:

Abaxis, Inc. - Sunnyvale CA

International Classification:

G01N 2117

US Classification:

436164

Abstract:

The present invention provides a compact, highly automated photometric analyzer for measuring the concentration of substances found in a fluid, typically a blood sample or other body fluid sample taken from a patient. The operator places a small quantity of the sample into a special rotor and then loads the rotor into the analyzer. The analyzer accepts the rotor, centrifuges and dilutes the sample, and distributes the sample into a plurality of cuvettes near the outer edge of the rotor. Some of these cuvettes hold reagents which react with the sample. The analyzer then measures light absorption within the sample at a number of preselected frequencies. According to the present invention, a pair of specially designed apertures direct light from the sample through a plurality of beam splitters, interference filters, and associated photodetectors. The system also includes means for performing automatic calibration and error checking functions. These means include a through hole through the rotor, and an opaque body carried by the rotor.