Robert A Nowinski

US Patent:

20130045211, Feb 21, 2013

Filed:

Jan 5, 2011

Appl. No.:

13/520601

Inventors:

Robert C. Nowinski - New York NY, US
Vincent A. Fischetti - New York NY, US
Assaf Raz - New York NY, US

Assignee:

THE ROCKEFELLER UNIVERSITY - New York NY
CONTRAFECT CORPORATION - New York NY

International Classification:

A61K 39/40
A01P 1/00
A61P 31/04
A01N 37/18
G01N 33/569

US Classification:

4241501, 4241651, 435 733

Abstract:

The present invention relates to methods and compositions for use in modulating, including inhibiting the growth and/or reducing the virulence of gram-positive bacteria. The present invention provides methods and compositions for disrupting the cell wall and/or cell membrane in gram-positive bacteria such that cell wall or cell membrane target(s) are rendered exposed or accessible and sensitive to a modulation thereof. Methods for modulation of one or more gram-positive bacterial cell wall or cell membrane targets in a gram-positive bacteria are provided comprising disrupting the cell wall such that the cell wall or cell membrane target, which is particularly a sortase, is rendered exposed or accessible and sensitive to a modifying, modulating or binding agent, which is particularly an antibody or fragment thereof, wherein the cell wall or cell membrane target is inaccessible or relatively insensitive to the modifying, modulating or binding agent in the absence of cell wall disruption.

US Patent:

20130302306, Nov 14, 2013

Filed:

Jun 4, 2013

Appl. No.:

13/909618

Inventors:

Raymond Schuch - Mountain Lakes NJ, US
Robert C. Nowinski - New York NY, US
Michael Wittekind - New Canaan CT, US
Han Lee - Yonkers NY, US
Brent Schneider - Glenmoore PA, US

International Classification:

A61K 38/46
A61K 38/14
A61K 38/12

US Classification:

424 946

Abstract:

The present invention provides compositions and methods for prevention, amelioration and treatment of gram positive bacteria, particularly Staphylococcal bacteria, with combinations of lysin, particularly Streptococcal lysin, particularly the lysin PlySs2, and one or more antibiotic, including daptomycin, vancomycin, oxacillin, linezolid, or related antibiotic(s).

US Patent:

20210128696, May 6, 2021

Filed:

Jan 5, 2021

Appl. No.:

17/141692

Inventors:

- Yonkers NY, US
Robert C. NOWINSKI - New York NY, US
Michael WITTEKIND - Bainbridge Island WA, US
Han LEE - Gaithersburg MD, US
Brent SCHNEIDER - Warminster PA, US

International Classification:

A61K 38/46
C12N 9/50
A61K 31/4188
A61K 31/5377
A61K 38/12
A61K 38/47
A61K 45/06
A61K 38/14

Abstract:

The present invention provides compositions and methods for prevention, amelioration and treatment of gram positive bacteria, particularly Staphylococcal bacteria, with combinations of lysin, particularly Streptococcal lysin, particularly the lysin PlySs2, and one or more antibiotic, including daptomycin, vancomycin, oxacillin, linezolid, or related antibiotic(s).

US Patent:

20210008175, Jan 14, 2021

Filed:

Sep 25, 2020

Appl. No.:

17/033195

Inventors:

- Yonkers NY, US
Robert C. NOWINSKI - New York NY, US
Michael WITTEKIND - Bainbridge Island WA, US
Han LEE - Yonkers NY, US
Brent SCHNEIDER - Glenmoore PA, US

International Classification:

A61K 38/46
C12N 9/50
A61K 31/4188
A61K 31/5377
A61K 38/12
A61K 38/47
A61K 45/06
A61K 38/14

Abstract:

The present invention provides compositions and methods for prevention, amelioration and treatment of gram positive bacteria, particularly Staphylococcal bacteria, with combinations of lysin, particularly Streptococcal lysin, particularly the lysin PlySs2, and one or more antibiotic, including daptomycin, vancomycin, oxacillin, linezolid, or related antibiotic(s).

US Patent:

20190387745, Dec 26, 2019

Filed:

Apr 22, 2019

Appl. No.:

16/391272

Inventors:

- Yonkers NY, US
Robert C. NOWINSKI - New York NY, US
Michael WITTEKIND - Bainbridge Island WA, US
Babar KHAN - Kingston NY, US
Jimmy ROTOLO - New York NY, US

International Classification:

A01N 63/00
C07K 14/315
A61L 29/16
A61L 29/08
A61K 45/06
A61K 38/47
A61K 38/16
C12N 9/50

Abstract:

The present invention provides methods for the prevention, control, disruption and treatment of bacterial biofilms with lysin, particularly lysin having capability to kill Staphlococcal bacteria, including drug resistant , particularly the lysin PlySs2. The invention also provides compositions and methods for use in treatment or modulation of bacterial biofilm(s) and biofilm formation.

US Patent:

20180221456, Aug 9, 2018

Filed:

Dec 20, 2017

Appl. No.:

15/848886

Inventors:

Raymond SCHUCH - Mountain Lakes NJ, US
Robert C. NOWINSKI - New York NY, US
Michael WITTEKIND - New Canaan CT, US
Han LEE - Yonkers NY, US
Brent SCHNEIDER - Glenmoore PA, US

International Classification:

A61K 38/46
A61K 38/12
A61K 38/14
A61K 38/47

Abstract:

The present invention provides compositions and methods for prevention, amelioration and treatment of gram positive bacteria, particularly Staphylococcal bacteria, with combinations of lysin, particularly Streptococcal lysin, particularly the lysin PlySs2, and one or more antibiotic, including daptomycin, vancomycin, oxacillin, linezolid, or related antibiotic(s).

US Patent:

20180125974, May 10, 2018

Filed:

Aug 11, 2017

Appl. No.:

15/675240

Inventors:

Robert C. Nowinski - New York NY, US
Vincent A. Fischetti - New York NY, US
Assaf Raz - New York NY, US

International Classification:

A61K 39/40
A61K 31/47
A61K 31/43
A61K 31/18
A61K 31/407
A61K 31/545
A61K 31/7008
A61K 31/7048
A61K 38/02
G01N 33/569

Abstract:

The present invention relates to methods and compositions for use in modulating, including inhibiting the growth and/or reducing the virulence of, gram-positive bacteria. The present invention provides methods and compositions for disrupting the cell wall and/or cell membrane in gram-positive bacteria such that cell wall or cell membrane target(s) are rendered exposed or accessible and sensitive to a modulation thereof. Methods for modulation of one or more gram-positive bacterial cell wall or cell membrane targets in a gram-positive bacteria are provided comprising disrupting the cell wall such that the cell wall or cell membrane target, which is particularly a sortase, is rendered exposed or accessible and sensitive to a modifying, modulating or binding agent, which is particularly an antibody or fragment thereof, wherein the cell wall or cell membrane target is inaccessible or relatively insensitive to the modifying, modulating or binding agent in the absence of cell wall disruption.

US Patent:

20170127683, May 11, 2017

Filed:

Oct 14, 2016

Appl. No.:

15/293586

Inventors:

Raymond Schuch - Mountain Lakes NJ, US
Robert C. Nowinski - New York NY, US
Michael Wittekind - New Canaan CT, US
Babar Khan - Kingston NY, US
Jimmy Rotolo - New York NY, US

International Classification:

A01N 63/00
A61K 45/06
A61K 38/47

Abstract:

The present invention provides methods for the prevention, control, disruption and treatment of bacterial biofilms with lysin, particularly lysin having capability to kill bacteria, including drug resistant particularly the lysin PlySs2. The invention also provides compositions and methods for use in treatment or modulation of bacterial biofilm(s) and biofilm formation.